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New approach to CAR T-cell therapy for B-cell cancers triples the targeted antigens on cancer cells

Researchers at University Hospitals Seidman Cancer Center and Case Western Reserve University have developed a novel approach to chimeric antigen receptor (CAR) T-cell therapy for B-cell cancers that triples the targeted antigens on cancer cells – a "back up" approach that promises to greatly reduce the potential for antigen escape currently found in CAR T therapies that solely target CD19.

2 Feb 2022

New nanoparticle SARS-CoV-2 vaccine shows stronger, broader, and more durable protection

The first generation of COVID-19 vaccines have been highly effective, but also have limitations: their efficacy can wane without a booster shot, and they may be less effective against some variants.

2 Feb 2022

Gut bacteria transfer genes through sex to take vitamin B12, study shows

Your gut bacteria need vitamin B12 just as much as you do. Though DNA is usually passed from parent to child, new research shows gut bacteria transfer genes through "sex" in order to take their vitamins.

2 Feb 2022

Research supports the need for a 3rd mRNA COVID vaccine in patients taking immunosuppressants

New research posted to the medRxiv* preprint server finds patients with immune-mediated inflammatory diseases undergoing anti-TNF therapy had the greatest reduction of antibody levels three months after vaccination. In addition, they had weaker neutralization responses towards severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern.

1 Feb 2022

Experimental immunotherapy could help treat some people with metastatic breast cancer

An experimental form of immunotherapy that uses an individual's own tumor-fighting immune cells could potentially be used to treat people with metastatic breast cancer, according to results from an ongoing clinical trial led by researchers at the National Cancer Institute's Center for Cancer Research, part of the National Institutes of Health.

1 Feb 2022

COVID-19 vaccines induce robust cellular immune response against SARS-CoV-2 Omicron

A team of scientists from the United States has recently demonstrated that current coronavirus disease 2019 (COVID-19) vaccines induce robust spike-specific T cell responses against the Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

1 Feb 2022

Liver hormone suppresses alcohol consumption in primates, study shows

A hormone produced by the liver called fibroblast growth factor 21 (FGF21) suppresses alcohol consumption in primates, finds a study published February 1 in the journal Cell Metabolism.

1 Feb 2022

Study confirms SARS-CoV-2 Omicron variant has a decreased ability to enter lung cells

A large multinational group of researchers has shown how the Omicron variant of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has gained exceptional immune evasion properties but also a much lower propensity to enter cells such as those in lung alveoli, resulting in its reduced pathogenicity. Their paper is currently released as an unedited version of the manuscript prior to publication in the journal Nature.

1 Feb 2022

Nanomedicine can be improved with proper and more predictive in vitro assays

Messenger RNA (mRNA) vaccines are a prime example of the promising field of nanomedicine. But progress in the design and application of nanoparticles as efficient delivery vehicles for biopharmaceutics containing nucleic acid or protein drug substances is, unfortunately, remarkably slow.

1 Feb 2022

Developing post-vaccination SARS-CoV-2 standard reference sera

A new study reports the generation of reference sera reagents that were obtained from subjects vaccinated with one of four COVID-19 vaccines.

1 Feb 2022

Individual dosing of preparatory drug makes stem cell transplants safer for children

Individual dosing of a drug used to prepare children for stem cell transplantation makes this treatment safer. That's according to new research by scientists from the Princess Máxima Center and the Wilhelmina Children's Hospital.

1 Feb 2022

Researchers discover why patients suffering with hypertension also have diabetes

The long-standing enigma of why so many patients suffering with high blood pressure (known as hypertension) also have diabetes (high blood sugar) has finally been cracked by an international team led by the universities of Bristol, UK, and Auckland, New Zealand.

1 Feb 2022

New RNA therapies for the treatment of heart failure and organ fibrosis

RNA has already been making an impact in the context of the vaccine program, but the potential of RNA-based compounds is far from being fully tapped, as RNA allows for entirely new therapeutic approaches.

1 Feb 2022

SARS-CoV-2 entry at the cell surface facilitated by trypsin

Exogenous trypsin treatment boosts SARS-CoV-2 infection in Vero E6 cells and promotes viral multiplication in cultured cells.

1 Feb 2022

Study reveals seven major determinants of mortality risk for patients with COVD-19 and thoracic cancer

The risk of death for patients with SARS-CoV-2 infection and thoracic cancer is based on seven major determinants, according to research published in the Journal of Thoracic Oncology, the official journal of the International Association for the Study of Lung Cancer.

1 Feb 2022

New machine-learning model could speed up the process of developing new medicines

Antibodies, small proteins produced by the immune system, can attach to specific parts of a virus to neutralize it.

1 Feb 2022

New blood test quickly detects COVID-19 infection and disease severity

George Washington University researchers have developed a blood test that quickly detects if someone has COVID-19 and predicts how severely the immune system will react to the infection, according to a new study coming out today in PLOS One.

1 Feb 2022

Neural stem cells plus HER2 inhibitor drug improve survival in mice with metastatic cancer

Neural stem cells (NSCs) engineered by Northwestern Medicine investigators used in combination with the HER2 inhibitor drug tucatinib improved survival in mice with HER2-positive breast cancer brain metastases, according to findings published in Proceedings of the National Academy of Sciences.

1 Feb 2022

Mutational analysis of SARS-CoV-2 main protease

A new study discussed the findings of a comprehensive mutational analysis of the main protease (Mpro) of SARS-CoV-2.

1 Feb 2022

Impact of using AI to generate primers for detection of SARS-CoV-2 Omicron variant

In a new study, researchers designed artificial intelligence (AI)-based primers for the SARS-CoV-2 Omicron variant.

1 Feb 2022

B Cell News and Research

New approach to CAR T-cell therapy for B-cell cancers triples the targeted antigens on cancer cells

New nanoparticle SARS-CoV-2 vaccine shows stronger, broader, and more durable protection

Gut bacteria transfer genes through sex to take vitamin B12, study shows

Research supports the need for a 3rd mRNA COVID vaccine in patients taking immunosuppressants

Experimental immunotherapy could help treat some people with metastatic breast cancer

COVID-19 vaccines induce robust cellular immune response against SARS-CoV-2 Omicron

Liver hormone suppresses alcohol consumption in primates, study shows

Study confirms SARS-CoV-2 Omicron variant has a decreased ability to enter lung cells

Nanomedicine can be improved with proper and more predictive in vitro assays

Developing post-vaccination SARS-CoV-2 standard reference sera

Individual dosing of preparatory drug makes stem cell transplants safer for children

Researchers discover why patients suffering with hypertension also have diabetes

New RNA therapies for the treatment of heart failure and organ fibrosis

SARS-CoV-2 entry at the cell surface facilitated by trypsin

Study reveals seven major determinants of mortality risk for patients with COVD-19 and thoracic cancer

New machine-learning model could speed up the process of developing new medicines

New blood test quickly detects COVID-19 infection and disease severity

Neural stem cells plus HER2 inhibitor drug improve survival in mice with metastatic cancer

Mutational analysis of SARS-CoV-2 main protease

Impact of using AI to generate primers for detection of SARS-CoV-2 Omicron variant

Industry focus eBook - Cell and gene therapy (2nd edition) eBook

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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