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Illustrating the structural diversity of SARS-CoV-2 Omicron spike

In a new study, a team of researchers used cryo-electron microscopy to determine the spike (S) structures of the SARS-CoV-2 Omicron variant to understand how the mutations that alter its primary sequence impact S conformation.

1 Feb 2022

Exploring beta-coronavirus neutralization by vaccine-induced murine antibody WS6

In a new study, researchers evaluated the neutralizing antibody titers in mice vaccinated with messenger ribonucleic acid (mRNA) encoding SARS-CoV-2 spike (S) protein.

1 Feb 2022

Ingenza collaborates with Johnson Matthey for efficient industrial enzyme synthesis

Biotechnology company Ingenza is excited to report the successful conclusion to its recent six-month project with Johnson Matthey.

1 Feb 2022

Researchers visualize protein machinery of respiration for the first time

Oxygen and sugar are the basis of life for animals, plants, fungi and many bacteria. The metabolic process called respiration makes it possible to convert food into energy for the cells.

31 Jan 2022

Growth factor can powerfully counter the harmful effects of inflammatory bowel disease

A growth factor protein produced by rare immune cells in the intestine can protect against the effects of inflammatory bowel disease (IBD), according to a new discovery from Weill Cornell Medicine researchers.

31 Jan 2022

New study on mutation origination fundamentally challenges neo-Darwinism

A new study by a team of researchers from Israel and Ghana has brought the first evidence of nonrandom mutation in human genes, challenging a core assumption at the heart of evolutionary theory by showing a long-term directional mutational response to environmental pressure.

31 Jan 2022

Combined strategy suppresses the growth of deadly brain tumor

Short bursts of radiation therapy dramatically enhanced the efficiency of targeting glioblastomas with natural nanoparticle-based immunotherapy, thus suppressing growth of the deadly tumor, inducing anti-tumor immunity and prolonging survival in animal models, a research team at Massachusetts General Hospital has discovered.

31 Jan 2022

MCL1 regulates neuronal autophagy, cell survival in Alzheimer's disease

Announcing a new review article publication for Acta Materia Medica journal. In this review article, the authors discuss the emerging neuroprotective function of MCL1 and how dysregulation of MCL1 signaling is involved in the pathogenesis of AD.

31 Jan 2022

Drugs derived from activated protein C may limit ischemia and reperfusion injury, study suggests

A University of South Florida Health preclinical study offers molecular insight into how activated protein C (APC) may improve aging patients' tolerance to reperfusion injury – a potentially adverse effect of treatment for ischemic heart disease.

31 Jan 2022

Researchers identify genetic cause of rare interstitial lung disease in a young child

New research from Washington University School of Medicine in St. Louis has solved the medical mystery of why a 2-year-old child — seemingly healthy at birth — succumbed to an undiagnosed, rare illness.

31 Jan 2022

Study reveals potential mechanism for iron accumulation in the aging brain

Breakdowns in regulatory mechanisms cause iron to build up in the brain as organisms grow older, increasing oxidative stress and causing cellular damage, according to a Northwestern Medicine study published in the journal eLife.

31 Jan 2022

3C-like protease inhibitor clinical candidate, S-217622, as a treatment for SARS-CoV-2

In a new study, a team of researchers discovered S-217622, a non-covalent SARS-CoV-2 3C-like protease (3CLpro) inhibitor clinical candidate for the treatment of COVID-19.

31 Jan 2022

Leica Microsystems ready to welcome researchers at EMBL Imaging Centre

Leica Microsystems, a leading manufacturer of microscopes and scientific instruments, has announced the opening of the new laboratories within the all-new Imaging Centre at the European Molecular Biology Laboratory (EMBL) in Heidelberg. The state-of-the-art imaging centre will serve as an important hub to drive collaborative research.

From Leica Microsystems GmbH 31 Jan 2022

Study finds how a change in cell environment triggers autism with genetic vulnerability

People with autism spectrum disorders all have characteristic behavioral difficulties. Nevertheless, the important heterogeneity of their symptoms remains one of the major questions for scientists and physicians.

31 Jan 2022

Evaluating clinical outcomes and viral loads of SARS-CoV-2 Delta and Omicron infections

The current study showed a marked decrease in disease severity with Omicron compared to the Delta variant.

31 Jan 2022

Prion-like domains in SARS-CoV-2 RBD and ACE2 play important functional roles in viral adhesion and entry

Scientists have recently detected and analyzed viral PrDs in the S protein of SARS-CoV-2, which are the novel regulators of virion assembly.

31 Jan 2022

Binding and conformational properties of the SARS-CoV spike protein and hACE2 complex

A new paper in the journal Molecules describes this in molecular terms, comparing SARS-CoV-2 with an earlier highly pathogenic coronavirus, SARS-CoV.

31 Jan 2022

Vaccine-induced immunological memory is similar for Omicron and Delta SARS-CoV-2 variants

A new study by Norwegian researchers suggests that vaccine-induced immunological memory and the activation of recall responses in the body yields similar coverage for Omicron and Delta variants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The paper is currently available on the medRxiv* preprint server while it undergoes peer review.

31 Jan 2022

Research shows minks mimic severe COVID-19 symptoms, including ARDS

Minks may be a suitable animal model for testing severe COVID-19 infections, finds a recent bioRxiv* preprint study. While mice and ferrets are used in preclinical severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), there is currently no model specific to severe disease.

30 Jan 2022

Study shows homologous COVID boosters better than heterologous in most kidney transplant recipients

Researchers screen kidney transplant recipients to evaluate their serological responses following immunization with three doses of the COVID-19 vaccine.

30 Jan 2022

B Cell News and Research

Illustrating the structural diversity of SARS-CoV-2 Omicron spike

Exploring beta-coronavirus neutralization by vaccine-induced murine antibody WS6

Ingenza collaborates with Johnson Matthey for efficient industrial enzyme synthesis

Researchers visualize protein machinery of respiration for the first time

Growth factor can powerfully counter the harmful effects of inflammatory bowel disease

New study on mutation origination fundamentally challenges neo-Darwinism

Combined strategy suppresses the growth of deadly brain tumor

MCL1 regulates neuronal autophagy, cell survival in Alzheimer's disease

Drugs derived from activated protein C may limit ischemia and reperfusion injury, study suggests

Researchers identify genetic cause of rare interstitial lung disease in a young child

Study reveals potential mechanism for iron accumulation in the aging brain

3C-like protease inhibitor clinical candidate, S-217622, as a treatment for SARS-CoV-2

Leica Microsystems ready to welcome researchers at EMBL Imaging Centre

Study finds how a change in cell environment triggers autism with genetic vulnerability

Evaluating clinical outcomes and viral loads of SARS-CoV-2 Delta and Omicron infections

Prion-like domains in SARS-CoV-2 RBD and ACE2 play important functional roles in viral adhesion and entry

Binding and conformational properties of the SARS-CoV spike protein and hACE2 complex

Vaccine-induced immunological memory is similar for Omicron and Delta SARS-CoV-2 variants

Research shows minks mimic severe COVID-19 symptoms, including ARDS

Study shows homologous COVID boosters better than heterologous in most kidney transplant recipients

Using single B cell screening to boost antibody discovery eBook

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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