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Predicting pregnancy health and preeclampsia risk with blood RNA sequencing

In this interview, News-Medical speaks to Dr. Thomas McElrath about his latest research into a maternal-fetal medicine technique for predicting pregnancy health.

27 Jan 2022

Drug combo delivered in a nanoparticle formulation extends the survival of mice with medulloblastoma

UNC Lineberger Comprehensive Cancer Center researchers have demonstrated that a novel combination of two drugs that act as targeted inhibitors, delivered in a nanoparticle formulation, extend the survival of mice with medulloblastoma.

27 Jan 2022

Targeting SARS-CoV-2 M protein may help ease severity of COVID-19

A new study, published on the medRxiv preprint server, focused on the production of human CD4+ T cell lines (TCLs), reactive to either S or M protein, and analyzed if the S and M structural proteins had intrinsic differences in driving antigen-specific CD4+ T cell responses.

27 Jan 2022

Omicron RBD mutations increase ACE2 binding and reduce antibody sensitivity

In a study conducted at the Florida International University, USA, scientists have investigated the impact of spike receptor-binding domain (RBD) mutations of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) omicron variant on its interaction with human angiotensin-converting enzyme 2 (ACE2).

26 Jan 2022

Immunosuppressed patients can benefit from COVID-19 booster vaccination, study shows

Patients under immunosuppressive therapy, who do not respond to primary COVID-19 vaccination, have an increased risk for severe COVID-19 disease courses. Until now, it was not clear whether those patients at risk can benefit from an additional booster vaccination.

26 Jan 2022

T-cell apoptosis linked to poor prognosis among COVID-19 patients

Researchers assess the probability of T-cell apoptosis in patients with severe COVID-19 who were admitted to the hospital.

26 Jan 2022

Microbiome 'profiling' may help identify people at risk of long COVID

The make-up of the gut microbiome may be linked to a person's risk of developing 'long COVID' many months after initial infection with SARS-CoV-2, the virus responsible for COVID-19 infection, suggests research published online in the journal Gut.

26 Jan 2022

Study shows enduring T-cell immunity up to at least 1-year after SARS-CoV-2 infection

A new study assesses SARS-CoV-2 antigen-specific cytokine responses in a cohort of SARS-CoV-2 infected individuals with varying levels of disease.

26 Jan 2022

Study provides a new treatment option for patients with relapsed B-cell lymphoma

A new therapy showed improvement over the standard treatment for relapsed B-cell lymphoma, according to a study published in the New England Journal of Medicine.

26 Jan 2022

Homologous and heterologous COVID-19 booster vaccines found to be safe and immunogenic

In adults who had previously received a full regimen of any of three COVID-19 vaccines granted Emergency Use Authorization (EUA) or approved by the U.S. Food and Drug Administration, an additional booster dose of any of these vaccines was safe and prompted an immune response, according to preliminary clinical trial results reported in The New England Journal of Medicine.

26 Jan 2022

Cross-recognition of SARS-CoV-2 vaccine-elicited T cell responses among different variants

In a new study, researchers evaluated SARS-CoV-2 vaccination-induced T cell responses cross-recognition among the early and novel SARS-CoV-2 variants.

26 Jan 2022

Study suggests synthetic SARS-CoV-2 S glycoprotein coated lipid vesicles are an effective vaccine candidate

In a new study, a team of researchers developed a vaccine candidate with the SARS-CoV-2 spike (S) glycoprotein coated onto lipid vesicles which resembles virus-like particles.

26 Jan 2022

Exploring hematological alterations in COVID-19 patients

New study findings indicated that some hematological alterations that occur during COVID-19-related hospital admission were associated with an increase in the risk of COVID-19-associated ICU admission and mortality.

26 Jan 2022

Endosomal sorting of neuropilin-1 in SARS-CoV-2 infectivity

A study recently identified Neurolipin-1 or NRP1, a host factor for SARS-CoV-2 infection, as a cargo retrograde-transported by the ESCPE-1.

26 Jan 2022

Study demonstrates differential alternative splicing in betacoronaviruses

A new study investigates whether the proportion of ribosomal genes displaying differential gene expression and differential alternative splicing differed between three betacoronaviruses and six other viruses and bacteria.

26 Jan 2022

Study finds overexpression of 3 SARS-CoV-2 genes could globally compromise transcriptome of human pluripotent stem cell-derived cardiomyocytes

In a recent study, whole mRNA-seq was used to investigate the global effects of SARS-CoV-2 viral genes Nsp6, Nsp8, and M on the transcriptome of hPSC-CMs.

26 Jan 2022

The Role of Glycans in the Cell and Glycans Imaging Method

DoD Awards Contract to Siemens Healthineers to Purchase COVID-19 Antigen Over-the-Counter Test Kits in Support of POTUS' 500 Million Free At-Home COVID-19 Tests

On Jan. 21, 2022, the Department of Defense (DoD) awarded a contract to Siemens Healthineers to procure 50 million over-the-counter COVID-19 test kits.

From Siemens Healthineers 26 Jan 2022

B Cell News and Research

Predicting pregnancy health and preeclampsia risk with blood RNA sequencing

Drug combo delivered in a nanoparticle formulation extends the survival of mice with medulloblastoma

Targeting SARS-CoV-2 M protein may help ease severity of COVID-19

Omicron RBD mutations increase ACE2 binding and reduce antibody sensitivity

Immunosuppressed patients can benefit from COVID-19 booster vaccination, study shows

T-cell apoptosis linked to poor prognosis among COVID-19 patients

Microbiome 'profiling' may help identify people at risk of long COVID

Study shows enduring T-cell immunity up to at least 1-year after SARS-CoV-2 infection

Study provides a new treatment option for patients with relapsed B-cell lymphoma

Homologous and heterologous COVID-19 booster vaccines found to be safe and immunogenic

Cross-recognition of SARS-CoV-2 vaccine-elicited T cell responses among different variants

Study suggests synthetic SARS-CoV-2 S glycoprotein coated lipid vesicles are an effective vaccine candidate

Exploring hematological alterations in COVID-19 patients

Endosomal sorting of neuropilin-1 in SARS-CoV-2 infectivity

Study demonstrates differential alternative splicing in betacoronaviruses

Study finds overexpression of 3 SARS-CoV-2 genes could globally compromise transcriptome of human pluripotent stem cell-derived cardiomyocytes

The Role of Glycans in the Cell and Glycans Imaging Method

The new Omicron subvariant BA.2: what we know so far

SARS-CoV-2 Omicron variant found to display increased resilience to antiviral type I interferon response

DoD Awards Contract to Siemens Healthineers to Purchase COVID-19 Antigen Over-the-Counter Test Kits in Support of POTUS' 500 Million Free At-Home COVID-19 Tests

Using single B cell screening to boost antibody discovery eBook

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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