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Cat coronavirus drug shows promise for treatment of COVID-19

“They are strong drug candidates for the treatment of human coronavirus infections because they have already been successful in animals (cats),” writes the team. “The work here lays the framework for their use in human trials for the treatment of COVID-19.”

5 May 2020

AGA publishes new COVID-19 recommendations for gastroenterologists

AGA has published new expert recommendations in Gastroenterology: AGA Institute Rapid Review of the GI and Liver Manifestations of COVID-19, Meta-Analysis of International Data, and Recommendations for the Consultative Management of Patients with COVID-19.

5 May 2020

Hydroxychloroquine shown to slow recovery for COVID-19 patients

As researchers try to piece together a therapeutic strategy against the ongoing COVID-19 pandemic, a recent retrospective study from Cleveland Clinic Abu Dhabi, assessed the Hydroxychloroquine's efficacy in increasing SARS-CoV-2 viral clearance, finding that it appeared to significantly slow viral clearance in mild to moderately ill COVID-19 patients.

5 May 2020

COVID-19 progression linked to B cell activation

The disease course of COVID-19 is diverse, ranging from asymptomatic to fatal respiratory failure. Scientists have been working to uncover the immunological reasons behind this heterogeneity. A recent study on B cells, published on the preprint server medRxiv in April 2020, shows that extrafollicular B cells could be a marker of severe infection in the early stages, predicting the need for earlier immunomodulatory therapy.

4 May 2020

Loss of smell may be related to neuroinvasive propensity of SARS-CoV-2

The novel coronavirus has rapidly infected millions over the world in over 187 countries and territories, causing hundreds of thousands of deaths. One of the often-neglected and under-reported symptoms of the virus is the loss of the sense of smell or anosmia. Now, a new study out of Germany published on the preprint server medRxiv in April 2020 provides a quantified estimate of the magnitude of anosmia as a symptom of the coronavirus.

4 May 2020

Uncovering immune cell reactions in COVID-19

A new study published on the preprint server medRxiv in April 2020 suggests that an overactive immune response is responsible for the more severe manifestations of the illness.

4 May 2020

Asymptomatic carriers transmit SARS-CoV-2 with normal breathing

The coronavirus disease (COVID-19) first emerged in a seafood market in Wuhan City, Hubei Province, China, in December 2019. Since then, it has spread to 187 countries, infecting more than 3.58 million people. The novel coronavirus spreads rapidly partly due to asymptomatic carriers. Now a new study shows that asymptomatic carriers may transmit the virus by merely breathing.

4 May 2020

Loss of smell should be listed as early symptom of COVID-19

Though the two common symptoms are cough and fever, recent studies and reports point to a loss of smell as a symptom early in the disease process. A team of researchers at the Technical University Dresden (TU Dresden) revealed that the sudden loss of smell is experienced by many patients infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

4 May 2020

Human endemic coronavirus reinfection possible after recovery

The novel coronavirus started spreading in December 2019, and since then, it has rippled across the globe, affecting 187 countries and territories, and infecting more than 3.18 million people. However, the behavior and mechanism of the virus, including whether it provides adaptive immunity, is still unclear. There have been reports of reinfection out of South Korea and Japan

4 May 2020

Dead virus fragments are causing COVID-19 reinfection false positives

The coronavirus disease (COVID-19) has ravaged across the globe, infecting a staggering 3.5 million people, and taking over 251,000 lives. One of the most significant concerns in this global pandemic is the possibility of reinfection as previous reports in South Korea and Japan show people testing positive with the coronavirus again.

4 May 2020

Study reveals an unprecedented pace and openness in COVID-19 research

The early academic response to coronavirus disease (COVID-19) was specified by research aiming to define the disease, with prompt response from all scholarly publishing stakeholders and short manuscript turnaround times, shows a new study available on the medRxiv* preprint server.

4 May 2020

New information on viral antigens could improve COVID-19 testing

Researchers in France and China have characterized antibody responses to a wide range of antigens present on severe acute respiratory syndrome-related coronavirus (SARS-CoV-2) among patients with coronavirus disease 2019 (COVID-19).

4 May 2020

New recommendations for treating the most critical COVID-19 patients

As the number of coronavirus cases continues to rise and the deaths mount, the American Society for Artificial Internal Organs has drafted a set of recommendations for health care workers on the front lines, to help them make decisions on how to treat the most critical patients, those with severe lung or heart failure

4 May 2020

A $10 million grant enables expansion of BCG vaccine trial against COVID-19

An A$10 million grant from the Bill & Melinda Gates Foundation will allow the Murdoch Children's Research Institute's clinical trial of the BCG vaccine against COVID-19 to extend to 10,000 healthcare workers across Australia, Spain and The Netherlands.

4 May 2020

Newly identified antibody prevents SARS-CoV-2 virus from infecting cultured cells

Researchers at Utrecht University, Erasmus Medical Center and Harbour BioMed (HBM) today reported that they have identified a fully human monoclonal antibody that prevents the SARS-CoV-2 (COVID-19) virus from infecting cultured cells.

4 May 2020

Study reveals variable sites in novel coronavirus SARS-CoV-2

Understanding the varying aggressiveness of SARS-CoV-2 may provide valuable data to trace its spread across populations. In the study, published on the preprint server BioRxiv, the researchers traced amino acid variants that possess high frequency in Europe, particularly in Italy, one of the hardest-hit countries.

4 May 2020

New antibiotic fights drug-resistant bacteria without notable toxic side-effects

Through serendipity, researchers at the University of Pittsburgh Graduate School of Public Health considerably reduced the toxicity of a potential antibiotic against the most feared drug-resistant bacteria, while also improving its stability in fighting infections.

4 May 2020

Scientists develop CRISPR-based test for SARS-CoV-2

Now, a team of scientists at the University of California Santa Barbara has developed a low-cost, rapid, and high-tech test that can detect SARS-CoV-2 effectively. They have developed a CRISPR-based test that is sensitive and effective as traditional tests.

4 May 2020

Researchers examine role of immune response in COVID-19 patients

A new USC study suggests that temporarily suppressing the body's immune system during the early stages of COVID-19 could help a patient avoid severe symptoms.

4 May 2020

SARS-CoV-2 receptor ‘mimic' could prevent COVID-19

Researchers from Italy have developed an exciting new peptide drug that could potentially prevent the coronavirus from infecting people’s cells. The paper, published on the preprint server bioRxiv* in April 2020, describes a small molecule that can bind to and block the attachment site on the virus spike protein, preventing its entry into the host cell.

4 May 2020