Animal Model News and Research

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Disruption of altered immune cells may blunt dangerous complications of preeclampsia, study shows

Though the exact cascade of events leading to preeclampsia is unknown, reduced blood flow to the placenta (placental ischemia) is commonly thought to be a factor that contributes to the development of the pregnancy-related condition.

24 Apr 2017

Penn researchers pinpoint underlying cause of Best disease

Named for Friedrich Best, who characterized the disease in 1905, Best disease, also known as vitelliform macular dystrophy, affects children and young adults and can cause severe declines in central vision as patients age.

19 Apr 2017

Bacteriophages may help combat antibiotic-resistant 'superbugs'

Viruses that specifically kill bacteria, called bacteriophages, might one day help solve the growing problem of bacterial infections that are resistant to antibiotic treatment.

18 Apr 2017

Research reveals how liver progenitor cells contribute to development of hepatic tumors

The malignant transformation of hepatocytes is the origin of most hepatocellular carcinomas, an aggressive type of liver cancer with high mortality rates. But these cells do not act alone.

18 Apr 2017

Research finding could offer new way to fight deadly pancreatic cancer

Pancreatic cancer, most frequently pancreatic ductal adenocarcinoma (PDAC), is the most lethal and aggressive of all cancers. Unfortunately, there are not many effective therapies available other than surgery, and that is not an option for many patients.

10 Apr 2017

Researchers use modified AAV as ‘Trojan Horse’ for delivering genes to restore congenital deafness

There are more than 300 genetic defects that have been found to prevent the hair cells in the human inner ear, the sensory cells of the ear as it were, from working properly.

6 Apr 2017

Researchers develop stable brain implant based on anti-inflammatory coating

Complex neurotechnological devices are required to directly select and influence brain waves inside the skull's interior. Although it has become relatively easy to implement the devices, researchers are still faced with challenges when trying to keep them running properly in living organisms over time.

5 Apr 2017

Researchers achieve new step towards treatment of myotubular myopathy using gene therapy

A team of researchers in France, led by Dr. Ana Buj-Bello (Genethon/Inserm) and teams at the University of Washington and Harvard Medical School in the United States, achieved a new step towards the treatment of myotubular myopathy by gene therapy.

5 Apr 2017

OIST scientists use zebrafish model to unravel causes behind human LCA

Newborns babies can be at risk of congenital blindness, presenting sight defects due to lesions or to genetic mutations in their genome.

5 Apr 2017

Organoids in cell culture dish offer new insights into development of the brain

A new method could push research into developmental brain disorders an important step forward. This is shown by a recent study at the University of Bonn in which the researchers investigated the development of a rare congenital brain defect.

4 Apr 2017

Researchers find link between hormones and inguinal hernias in older men

Researchers have identified an apparent cause of inguinal hernia, or groin hernia, in older men: altered sex hormone levels that weaken and scar muscle tissue in the lower abdomen.

3 Apr 2017

Researchers enhance safety, effectiveness of potential HIV vaccine using on/off genetic switch

By engineering an on/off switch into a weakened form of HIV, University of Nebraska-Lincoln researchers have enhanced the safety and effectiveness of a potential vaccine for the virus that has killed approximately 35 million people during the past 35 years.

30 Mar 2017

Cerebellar stimulation improves schizophrenia-like thinking problems in rats

"A beautiful, lobular structure," is how Krystal Parker describes the cerebellum - a brain region located at the base of the skull just above the spinal column.

28 Mar 2017

Stem cell therapy can reduce lung inflammation in mouse model of COPD and cystic fibrosis

A new study has found that stem cell therapy can reduce lung inflammation in an animal model of chronic obstructive pulmonary disease (COPD) and cystic fibrosis. Although, still at a pre-clinical stage, these findings have important potential implications for the future treatment of patients.

25 Mar 2017

Exposure to acrolein causes failure of immune defence to tumours, study finds

The World Health Organisation estimates that every year 600,000 deaths are caused by passive smoking worldwide and, in Austria alone, two or three people a day die as a result of passive smoking.

25 Mar 2017

OTUD6B gene mutations linked to physical and intellectual deficits

An international team of researchers from institutions around the world, including Baylor College of Medicine, has discovered that mutations of the OTUD6B gene result in a spectrum of physical and intellectual deficits.

24 Mar 2017

First-of-its-kind mouse model could help study post-malaria epilepsy in children

A first-of-its-kind mouse model could lead to an understanding of how cerebral malaria infection leads to the development of epilepsy in children, and to the prevention of seizures.

23 Mar 2017

TUM scientists show how diabetes damages small blood vessels around the heart

Diabetics have a significantly higher risk of suffering a heart attack. A research team at the Technical University of Munich has now identified one of the causes: Diabetes is associated with the loss of small blood vessels around the heart.

23 Mar 2017

Swedish researchers prove that 3D bioprinted human cartilage cells can be implanted

Swedish researchers at Chalmers University of Technology and Sahlgrenska Academy have successfully induced human cartilage cells to live and grow in an animal model, using 3D bioprinting.

23 Mar 2017

Intratumoral vaccination prolongs survival in mouse model of early stage resected pancreatic cancer

Building on their previous research focusing on vaccination within a tumor (intratumoral) for the most common form of pancreatic cancer, investigators from Rutgers Cancer Institute of New Jersey and Rutgers Robert Wood Johnson Medical School have shown that in a mouse model of early stage resected pancreatic cancer, intratumoral vaccination induces an anti-tumor response that results in a significant improvement in overall survival.

23 Mar 2017

Animal Model News and Research

Disruption of altered immune cells may blunt dangerous complications of preeclampsia, study shows

Penn researchers pinpoint underlying cause of Best disease

Bacteriophages may help combat antibiotic-resistant 'superbugs'

Research reveals how liver progenitor cells contribute to development of hepatic tumors

Research finding could offer new way to fight deadly pancreatic cancer

Researchers use modified AAV as ‘Trojan Horse’ for delivering genes to restore congenital deafness

Researchers develop stable brain implant based on anti-inflammatory coating

Researchers achieve new step towards treatment of myotubular myopathy using gene therapy

OIST scientists use zebrafish model to unravel causes behind human LCA

Organoids in cell culture dish offer new insights into development of the brain

Researchers find link between hormones and inguinal hernias in older men

Researchers enhance safety, effectiveness of potential HIV vaccine using on/off genetic switch

Cerebellar stimulation improves schizophrenia-like thinking problems in rats

Stem cell therapy can reduce lung inflammation in mouse model of COPD and cystic fibrosis

Exposure to acrolein causes failure of immune defence to tumours, study finds

OTUD6B gene mutations linked to physical and intellectual deficits

First-of-its-kind mouse model could help study post-malaria epilepsy in children

TUM scientists show how diabetes damages small blood vessels around the heart

Swedish researchers prove that 3D bioprinted human cartilage cells can be implanted

Intratumoral vaccination prolongs survival in mouse model of early stage resected pancreatic cancer

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