Endoplasmic reticulum (ER) News and Research

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Discovery of novel approach to suppress prostate cancer progression

Researchers at the University of Southern California (USC) have found that inactivating a specific biomarker for aggressive prostate cancer blocks the development of prostate cancer in animal models.

24 Nov 2008

ER/PR negative tumors associated with insurance status

African-American women are at a higher risk for ER/PR negative breast cancer.

18 Nov 2008

New research reveals key steps in HIV's assault on the brain

Scientists have unraveled in unprecedented detail the cascade of events that go wrong in brain cells affected by HIV, a virus whose assault on the nervous system continues unabated despite antiviral medications that can keep the virus at bay for years in the rest of the body.

16 Nov 2008

New clue for cellular damage in Huntington's disease

"Huntington's disease presents an ideal vantage point to study neurodegenerative disease, because we know the misfolded protein that's responsible," says Martin Duennwald, formerly a postdoctoral researcher in the lab of Whitehead Member Susan Lindquist.

16 Nov 2008

New blood test identifies sickest heart failure patients in ER

A new blood test identifies the sickest heart failure patients better than tests now used in emergency departments, researchers reported at the American Heart Association's Scientific Sessions 2008. Results of the Mid-Regional pro-Adrenomedullin (proADM) versus BNP and NTproBNP as Prognosticator in Heart Failure Patients: Results of the BACH Multinational Trial were presented as a late-breaking clinical trial.

11 Nov 2008

Researchers aim to over-stress already taxed mantle cell lymphoma cells

Cancer cells are already stressed by the fast pace they require to grow and spread and scientists believe a little more stress just may kill them.

11 Nov 2008

Study finds 25% of family caregivers of AD patients go to ER or are hospitalized

One quarter of all family caregivers of Alzheimer's disease patients succumb to the stress of providing care to a loved one and become hospital patients themselves, according to an Indiana University study published in the November 2008 issue of the Journal of General Internal Medicine.

10 Nov 2008

California Pacific Medical Center opens pediatric ER

California Pacific Medical Center is opening the first Emergency Department in San Francisco designed specifically to treat and meet the needs of children ages birth to 18 and their families.

6 Nov 2008

Study looks at children and teens physically victimized by peers

Mentoring youths, counseling parents can reduce youth violence, researchers say

4 Nov 2008

Young victims of violence benefit from counseling on how to avoid conflict

Researchers in the U.S. say young victims of violence can benefit from 'one on one' counseling - they say mentoring about how to safely avoid conflict and diffuse threats makes them far less likely to become victims again.

3 Nov 2008

Rapid HIV testing in the emergency department boosts diagnoses, screening

One in every 50 people screened for a suspected sexually transmitted infection (STI) in the Emergency Department at Henry Ford Hospital was found to be infected with HIV using a rapid blood sample screening test.

26 Oct 2008

Mylan receives tentative FDA approval for generic versions of Benicar and Uroxatral

Mylan Inc. today announced that its subsidiary, Mylan Pharmaceuticals Inc., received tentative approval from the U.S. Food and Drug Administration (FDA) for its Abbreviated New Drug Application (ANDA) for Olmesartan Medoxomil and Hydrochlorothiazide Tablets, 20 mg/12.5 mg, 40 mg/12.5 mg and 40 mg/25 mg.

22 Oct 2008

Barr Laboratories confirms Opana ER tablet patent challenge

Barr Pharmaceuticals, Inc. today confirmed that its subsidiary, Barr Laboratories, Inc., has initiated a challenge of the patents listed by Endo Pharmaceuticals Inc. in connection with its Opana(R) ER (oxymorphone hydrochloride) extended-release tablets, 5 mg, 10 mg, 20 mg and 40 mg.

22 Oct 2008

Burst appendix or stomach flu?

A young child arrives at the emergency room after several days of abdominal pain, vomiting, and diarrhea and is sent home with a diagnosis of viral gastritis and treatment for the symptoms. The child seems better for a while, only to return to the ER with worse symptoms and a ruptured appendix, a life-threatening complication of appendicitis.

6 Oct 2008

Receptor activation protects retina from diabetes destruction

A drug known for it pain-relieving power and believed to stimulate memory appears to prevent this retinal damage that leads to vision loss, researchers say.

9 Sep 2008

Sen. Grassley asking for details of hospital cost-cutting programs

Sen. Chuck Grassley (R-Iowa) has requested that two public hospitals submit information on programs and practices that he suggests could lead to unequal treatment of patients based on their ability to pay, the Wall Street Journal's "Health Blog" reports.

9 Sep 2008

World's first hand-held ultrasound imaging device

Siemens Canada Limited has partnered with Vancouver General Hospital (VGH) to implement the new ACUSON P10 ultrasound system - the world's first hand-held ultrasound imaging device - replacing the existing technology.

8 Sep 2008

Ortho-McNeil to appeal patent ruling on Razadyne

Ortho-McNeil Neurologics, Division of Ortho-McNeil-Janssen Pharmaceuticals, Inc. announced that it will appeal yesterday's decision by the U.S. District Court of Delaware, which ruled the patent for Razadyne (galantamine hydrobromide) is invalid.

28 Aug 2008

Barr receives U.S. approval for generic Razadyne tablets

Barr Pharmaceuticals, Inc. today announced that its subsidiary, Barr Laboratories, Inc., received final approval from the U.S. Food & Drug Administration (FDA) to manufacture and market a generic version of Ortho McNeil Janssen's Razadyne (galantamine hydrobromide), 4 mg, 8 mg and 12 mg tablets. Barr intends to launch its generic Razadyne tablets product immediately.

28 Aug 2008

Watson announces ruling in Naproxen sodium patent case

Watson Pharmaceuticals, Inc. announced today that the United States District Court for the Southern District of Florida ruled today that Watson's Naproxen Sodium ER tablets, the generic version of Naprelan, infringes Elan's U.S. Patent No. 5,637,320 (the "'320 Patent").

13 Aug 2008