Interleukin 2 News and Research

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NFCR-funded translational cancer research project receives $700,000 from Virginia Catalyst

A translational research project supported by the National Foundation for Cancer Research (NFCR) has been awarded $700,000 from Virginia Catalyst to advance its lead cancer drug candidate.

23 Dec 2019

Modern wheat does not impair gastrointestinal health in mice compared with heirloom variety

Amid concerns about gluten sensitivity, increasing numbers of people are avoiding wheat. Most have not been diagnosed with a wheat-related medical condition, yet they seem to feel better when they don't eat gluten-containing foods.

18 Dec 2019

Study finds new drivers of destructive inflammation

Scientists describe in Nature Immunology an entirely new molecular process in mice that triggers T cell-driven inflammation and causes different auto-immune diseases.

17 Dec 2019

Study: Blocking IL1α protein decreases severity of inflammation in Crohn's disease

Investigators at the Case Western Reserve University School of Medicine discovered that blocking interleukin-1α (IL1α), a protein that controls inflammation in the gut, markedly decreases the severity of intestinal inflammation in a mouse model of Crohn's disease (CD).

17 Dec 2019

Research uncovers mechanism that triggers inflammatory process by Mayaro virus

The mechanism by which defense cells respond to infection by Mayaro virus has been described by a team affiliated with the Center for Research on Inflammatory Diseases - CRID in an article published in the journal PLOS Pathogens.

2 Dec 2019

Researchers study the effects of hyperoxia on the lung development of germ-free newborn mice

Charitharth Vivek Lal, M.D., and University of Alabama at Birmingham colleagues have used a novel and first-of-its-kind newborn mouse model to study the effect of high oxygen concentrations, or hyperoxia, on lung development of newborn mice that are germ-free -- meaning no microbes colonizing their lungs.

21 Nov 2019

Research explains why immunotherapy fails against prostate cancer bone metastases

Prostate cancer that spreads to the bone triggers the destruction of bone tissue that, in turn, thwarts the effectiveness of immune checkpoint inhibitors by blocking the development of T cells that are crucial to successful treatment, researchers from The University of Texas MD Anderson Cancer Center report in Cell.

14 Nov 2019

New treatment stops peanut allergy for 6 weeks with single dose

A small study published in the journal JCI Insight on November 14, 2019, suggests that antibody treatment could help people with severe allergy to peanuts eat a small amount of peanut-containing food just two weeks later, without any ill effects. This seems to show that this is a safe, fast and effective treatment for food allergy.

14 Nov 2019

Methotrexate appears to facilitate bone remodeling in patients with osteoarthritis

According to new research findings presented at the 2019 ACR/ARP Annual Meeting, methotrexate did not demonstrate superior efficacy over placebo for pain relief and function evolution at three and 12 months in patients with erosive hand osteoarthritis.

11 Nov 2019

Vitamin D and omega-3 fatty acids are not effective at reducing systemic inflammation

Vitamin D and marine omega-3 fatty acids -- also known as fish oil -- are purported to have many health benefits, including reducing systemic inflammation.

7 Nov 2019

New study reveals why beta-blockers cause skin inflammation

Beta-blockers are often used to treat high blood pressure and other cardiovascular diseases. However, in some patients they can trigger or exacerbate psoriasis, an inflammatory skin disease.

7 Nov 2019

Myocardial infarction model developed using cardiomyocytes

Researchers at Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences developed a model of myocardial infarction using cardiomyocytes differentiated from human induced pluripotent stem cells.

7 Nov 2019

Factor responsible for formation of white blood cells has regulatory effect on adaptive immunity

Granulocyte colony-stimulating factor, which causes division and differentiation of bone marrow cells depending on the body's need for leukocytes, has a significant regulatory effect not only on innate, but also on adaptive immunity.

31 Oct 2019

Study: MIB2 improves inflammation by degrading CYLD enzyme

The tumor suppressor CYLD lysine 63 deubiquitinase (CYLD) is a deubiquitinating enzyme that suppresses polyubiquitin-dependent signaling pathways, including the proinflammatory and cell growth-promoting NF-κB pathway.

30 Oct 2019

High-salt diet may trigger dementia

We’ve all heard that taking too much salt can damage your blood vessels, and now a new study published in the journal Nature on October 23, 2019, says it’s true – a diet rich in salt reduces the levels of nitric oxide, which in turn alters the tau protein within the neuron, triggering a fall in cognitive processing by the brain.

24 Oct 2019

ALS patients with commonly inherited genetic variation may experience more severe symptoms

A discovery made several years ago in a lab researching asthma at Wake Forest School of Medicine may now have implications for the treatment of amyotrophic lateral sclerosis (ALS), a disease with no known cure and only two FDA-approved drugs to treat its progression and severity.

16 Oct 2019

New cancer treatment developed at Yale

Scientists at Yale have developed a method that assists the immune system in identifying and eliminating cancer cells that may be missed by other forms of immunotherapies.

15 Oct 2019

Dupilumab provides clinical benefit to adolescents with moderate-to-severe atopic dermatitis

Results from a phase IIa open-label trial and a subsequent phase III open-label extension trial reinforce findings from an earlier short-term trial that adolescents with moderate-to-severe atopic dermatitis, or eczema, can experience significant improvements with dupilumab.

9 Oct 2019

Combination treatment cures pancreatic cancer, reprograms the immune system

A University of Rochester Wilmot Cancer Institute research team reports that combining a type of radiation therapy with immunotherapy not only cures pancreatic cancer in mice, but appears to reprogram the immune system to create an "immune memory" in the same way that a vaccine keeps the flu away.

8 Oct 2019

New defensive mechanism against bacterial wound infections discovered

Wound inflammation which results in impaired wound healing can have serious consequences for patients. Researchers from Charité - Universitätsmedizin Berlin have discovered a new defensive mechanism which enables our skin to actively kill bacteria.

4 Oct 2019

Interleukin 2 News and Research

NFCR-funded translational cancer research project receives $700,000 from Virginia Catalyst

Modern wheat does not impair gastrointestinal health in mice compared with heirloom variety

Study finds new drivers of destructive inflammation

Study: Blocking IL1α protein decreases severity of inflammation in Crohn's disease

Research uncovers mechanism that triggers inflammatory process by Mayaro virus

Researchers study the effects of hyperoxia on the lung development of germ-free newborn mice

Research explains why immunotherapy fails against prostate cancer bone metastases

New treatment stops peanut allergy for 6 weeks with single dose

Methotrexate appears to facilitate bone remodeling in patients with osteoarthritis

Vitamin D and omega-3 fatty acids are not effective at reducing systemic inflammation

New study reveals why beta-blockers cause skin inflammation

Myocardial infarction model developed using cardiomyocytes

Factor responsible for formation of white blood cells has regulatory effect on adaptive immunity

Study: MIB2 improves inflammation by degrading CYLD enzyme

High-salt diet may trigger dementia

ALS patients with commonly inherited genetic variation may experience more severe symptoms

New cancer treatment developed at Yale

Dupilumab provides clinical benefit to adolescents with moderate-to-severe atopic dermatitis

Combination treatment cures pancreatic cancer, reprograms the immune system

New defensive mechanism against bacterial wound infections discovered

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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