Immune System News and Research

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Genomics researchers discover novel gene variants in childhood CVID

Genomics researchers analyzing a rare, serious immunodeficiency disease in children have discovered links to a gene crucial to the body's defense against infections. The finding may represent an inviting target for drugs to treat common variable immunodeficiency (CVID).

27 Feb 2015

Researchers reveal how human immune system can fight against deadly Marburg virus

A collaborative team from The University of Texas Medical Branch at Galveston, Vanderbilt University and The Scripps Research Institute have identified mechanisms involved in antibody response to the deadly Marburg virus by studying the blood of a Marburg survivor.

27 Feb 2015

ABIVAX doses first patient in ABX203 Phase IIb/III trial for treatment of chronic hepatitis B

ABIVAX, a clinical stage biotech company developing and commercialising anti-viral compounds and human vaccines, today announced that it has dosed in New Zealand the first patient in a Phase IIb/III clinical trial of ABX203 which is taking place in several countries of the Asia-Pacific region.

26 Feb 2015

Predicting the development of type 1 diabetes is possible, shows TEDDY study

New research shows that it is possible to predict the development of type 1 diabetes. By measuring the presence of autoantibodies in the blood, it is possible to detect whether the immune system has begun to break down the body's own insulin cells.

26 Feb 2015

Emulsifiers can alter gut microbiota composition to induce intestinal inflammation

Emulsifiers, which are added to most processed foods to aid texture and extend shelf life, can alter the gut microbiota composition and localization to induce intestinal inflammation that promotes the development of inflammatory bowel disease and metabolic syndrome, new research shows.

26 Feb 2015

Researchers warn doctors, parents not to give melatonin drug to control sleep problems in children

Sleep researchers at the University of Adelaide are warning doctors and parents not to provide the drug melatonin to children to help control their sleep problems.

26 Feb 2015

Researchers reveal how malaria parasite deploys genetic trickery to escape immune system attack

Up to one million people -- mainly pregnant woman and young children -- are killed each year by the Plasmodium falciparum parasite, which causes the most devastating form of human malaria.

26 Feb 2015

Psoriasis management: an interview with Dr Sandy McBride

A major challenge around treating psoriasis is communication - psoriasis can flare and resolve in between appointments so it can be difficult to express and describe the life impact of these flares and recall possible triggers and response to treatments. People with psoriasis can also find it very difficult to talk about their emotions – something known as alexithymia – again making it difficult for clinicians to fully appreciate the impact of psoriasis.

25 Feb 2015

Changes to DNA sequence associated with peanut allergy

Research funded by the National Institutes of Health suggests that changes in a small region of chromosome 6 are risk factors for peanut allergy in U.S. children of European descent. The genetic risk area is located among two tightly linked genes that regulate the presentation of allergens and microbial products to the immune system. This study is the first to use a genome-wide screening approach in patients with well-defined food allergy to identify risks for peanut allergy.

25 Feb 2015

PCF announces Challenge Awards to support research on new treatment strategies for prostate cancer

The Prostate Cancer Foundation (PCF) announces 3 new Challenge Awards to support discoveries for the treatment of lethal prostate cancer.

25 Feb 2015

Shire announces acquisition of Meritage Pharma

Shire plc and Meritage Pharma, Inc. announced today that Shire has acquired Meritage, a privately-held company, for an upfront fee of $70 million and additional contingent payments based on the achievement of development and regulatory milestones.

24 Feb 2015

Peanut consumption in infancy prevents allergy in kids who are at high-risk for developing peanut allergy

A new study reported today in the New England Journal of Medicine demonstrates that consumption of a peanut-containing snack by infants who are at high-risk for developing peanut allergy prevents the subsequent development of allergy.

24 Feb 2015

MD Anderson researchers find way to predict patients who may respond to BRAF inhibitors

Powerful drugs known as BRAF-inhibitors have been crucial for melanoma patients, saving lives through their ability to turn off the BRAF protein's power to spur cancer cell growth.

24 Feb 2015

Finding opens avenues of research toward precision treatments to boost life expectancy for CF patients

Mutation of one gene is all it takes to get cystic fibrosis (CF), but disease severity depends on many other genes and proteins. For the first time, researchers at the UNC School of Medicine have identified genetic pathways - or clusters of genes - that play major roles in why one person with CF might never experience the worse kinds of symptoms while another person will battle severe airway infection for a lifetime.

23 Feb 2015

Rigel, Bristol-Myers Squibb partner to develop, commercialize TGF beta receptor kinase inhibitors

Rigel Pharmaceuticals, Inc. and Bristol-Myers Squibb Company today announced that they have entered into a collaboration agreement for the discovery, development and commercialization of cancer immunotherapies based on Rigel's extensive portfolio of small molecule TGF beta receptor kinase inhibitors.

23 Feb 2015

RepliCel submits CTA for RCS-01 study to treat patients suffering from aged, UV-damaged skin

RepliCel Life Sciences Inc., a clinical stage regenerative medicine company focused on the development of autologous cell therapies, today announced the submission of a Clinical Trial Application (CTA) to the German Competent Authority, the Paul-Ehrlich-Institut (PEI), requesting clearance to initiate a Phase 1 clinical trial investigating the use of RCS-01 to treat patients suffering from aged and UV-damaged skin.

23 Feb 2015

Henry Ford researchers say that breastfeeding influences baby's immune system development

Henry Ford Hospital researchers say that breastfeeding and other factors influence a baby's immune system development and susceptibility to allergies and asthma by what's in their gut.

23 Feb 2015

Case Western dental researcher discovers new way to model how T cells cause inflammation in mice

Case Western Reserve University dental researcher Pushpa Pandiyan has discovered a new way to model how infection-fighting T cells cause inflammation in mice.

23 Feb 2015

MD Anderson awarded more than $22 million in research grants from CPRIT

The University of Texas MD Anderson Cancer Center has received more than $22 million in research grants this week from the Cancer Prevention and Research Institute of Texas. Approximately half of the funds awarded for Individual Investigator Research Awards went to MD Anderson faculty as well as 40 percent of total IIRA awards that include those for children's and adolescent cancer and early detection and prevention.

21 Feb 2015

International phase 2/3 trial shows Gardasil 9 vaccine protects against nine HPV types

Approximately 12,000 women are diagnosed with cervical cancer each year in the United States and another 4,000 die annually from the disease. However, most cervical cancers are preventable through immunization against the human papillomavirus (HPV). A pivotal international phase 2/3 clinical trial involving Moffitt Cancer Center faculty demonstrated that vaccination with Gardasil 9 protects against nine HPV types, seven of which cause most cases of cervical, vulvar, and vaginal disease.

21 Feb 2015

Immune System News and Research

Genomics researchers discover novel gene variants in childhood CVID

Researchers reveal how human immune system can fight against deadly Marburg virus

ABIVAX doses first patient in ABX203 Phase IIb/III trial for treatment of chronic hepatitis B

Predicting the development of type 1 diabetes is possible, shows TEDDY study

Emulsifiers can alter gut microbiota composition to induce intestinal inflammation

Researchers warn doctors, parents not to give melatonin drug to control sleep problems in children

Researchers reveal how malaria parasite deploys genetic trickery to escape immune system attack

Psoriasis management: an interview with Dr Sandy McBride

Changes to DNA sequence associated with peanut allergy

PCF announces Challenge Awards to support research on new treatment strategies for prostate cancer

Shire announces acquisition of Meritage Pharma

Peanut consumption in infancy prevents allergy in kids who are at high-risk for developing peanut allergy

MD Anderson researchers find way to predict patients who may respond to BRAF inhibitors

Finding opens avenues of research toward precision treatments to boost life expectancy for CF patients

Rigel, Bristol-Myers Squibb partner to develop, commercialize TGF beta receptor kinase inhibitors

RepliCel submits CTA for RCS-01 study to treat patients suffering from aged, UV-damaged skin

Henry Ford researchers say that breastfeeding influences baby's immune system development

Case Western dental researcher discovers new way to model how T cells cause inflammation in mice

MD Anderson awarded more than $22 million in research grants from CPRIT

International phase 2/3 trial shows Gardasil 9 vaccine protects against nine HPV types

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