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Study supports use of PRX as an anti-cataract agent

Scientists are reporting a scientific basis for the long-standing belief that a widely used non-prescription drug in China and certain other countries can prevent and treat cataracts, a clouding of the lens of the eye that is a leading cause of vision loss worldwide. Their study appears in Inorganic Chemistry, an ACS journal.

13 Jan 2011

Brain cell destroying genetic mechanism responsible for development of AD

Researchers at the University of British Columbia and Vancouver Coastal Health Research Institute have discovered that the genetic mechanism which destroys brain cells is responsible for early development of Alzheimer's Disease in people with Down Syndrome and for development of Alzheimer's Disease in general population - providing a potential new target for drugs that could forestall dementia in people with either condition.

13 Jan 2011

7,8-Dihydroxyflavone holds potential for treatment of fear based disorders

Living a traumatic experience favours the persistence of fear associated with an aversive stimulus, known as fear conditioning and such effect, in mice, can be suppressed with a single dosis of 7,8-Dihydroxyflavone, a type of flavonoid which boosts the ability to acquire new emotional learnings.

13 Jan 2011

TKM-PLK1 drug may offer hope for patients with advanced solid tumor cancers

A new investigational drug designed to stop cancer cells from reproducing may offer hope for patients with advanced solid tumor cancers. Clinical trials of TKM-PLK1 for qualified patients are now open at the Virginia G. Piper Cancer Center at Scottsdale Healthcare.

13 Jan 2011

New discovery has brought dream of transforming measles virus against cancer

When most people in the developed world think of measles, what comes to mind is only a dim memory of a vaccination at a pediatrician's office. But while childhood vaccination has virtually eliminated measles from North America and much of Europe, researchers remain interested in the virus.

13 Jan 2011

Aβ, tau and Fyn protein interactions may lead to brain dysfunction and AD

Though the cause of Alzheimer's disease still is unknown, recent studies have implicated three proteins strongly in its onset. New research from the University of Alabama at Birmingham, the Gladstone Institutes and the Baylor College of Medicine indicates that interactions between those three proteins might lead to brain dysfunction and AD in a mouse model of the disease.

13 Jan 2011

Obesity in children today may contribute to 2-5 year decline in life expectancy

For the first time in history, the next generation will not live longer, or even as long, as their parents. "Diseases such as Type II diabetes, high blood pressure, heart conditions and joint deterioration - what were once considered 'adult' diseases - are regularly being diagnosed in children, due to the prevalence of obesity," said Jessica Bartfield, MD, internal medicine and medical weight-loss specialist at Gottlieb Memorial Hospital, part of the Loyola University Health System.

13 Jan 2011

Micromet, MedImmune initiate MT111 Phase 1 trial in patients with advanced gastrointestinal cancer

MedImmune, the global biologics unit of AstraZeneca PLC and Micromet, today announced the initiation of a Phase 1 trial of MEDI-565 in patients with advanced gastrointestinal cancers. MEDI-565 is a BiTE antibody designed to direct a patient's T cells, the body's most potent killer cells, against cancer cells that express carcinoembryonic antigen.

13 Jan 2011

Study indicates disease's underlying causes in mice, finds compounds that normalize Alzheimer's brain

A Blanchette Rockefeller Neurosciences Institute study published today in the Journal of Neuroscience reveals underlying causes for the degeneration of synapses in Alzheimer's Disease and identifies promising pharmaceutical solutions for the devastating condition that affects more than 5 million people in the United States.

12 Jan 2011

Lipoprotein receptor LRP1 also regulates food intake and energy balance in central nervous system: Study

A study by researchers at Mayo Clinic's campus in Florida and Washington University School of Medicine adds a new twist to the body of evidence suggesting human obesity is due in part to genetic factors. While studying hormone receptors in laboratory mice, neuroscientists identified a new molecular player responsible for the regulation of appetite and metabolism.

12 Jan 2011

Offensive protein generated by HPV handicaps defensive protein made by the human body

An international team of researchers is reporting that it has uncovered new information about human papillomavirus that one day may aid in the development of drugs to eliminate the cervical-cancer-causing infection.

12 Jan 2011

Study shows delivering cancer drug in hydrophobic nanoparticle is a safe and effective prostate cancer therapy

Researchers at MIT and Brigham and Women's Hospital have shown that they can deliver the cancer drug cisplatin much more effectively and safely in a form that has been encapsulated in a nanoparticle targeted to prostate tumor cells and is activated once it reaches its target.

12 Jan 2011

Study reveals underlying causes for degeneration of synapses in Alzheimer's Disease

A Blanchette Rockefeller Neurosciences Institute (BRNI) study published today in the Journal of Neuroscience reveals underlying causes for the degeneration of synapses in Alzheimer's Disease and identifies promising pharmaceutical solutions for the devastating condition that affects more than 5 million people in the United States.

12 Jan 2011

Scientists introduce DNA directly into cell nucleus using protein nanodisks

One of the challenges of gene therapy - a set of methodologies aimed at treating several nucleic acid diseases - is to assure that this material arrives directly to the nucleus of the cell without losing a substantial amount along the way and without producing any undesired side effects. With this aim, scientists experiment with the use of different types of vectors, molecules capable of transporting genetic material to the correct place.

12 Jan 2011

New database provides easy access to information about genes and biological functions

The human genome sequence, initially completed in draft form nearly a decade ago, has revolutionized biological research. But most research findings are buried in the scientific literature, and linking basic biological processes to genomic information can be difficult without substantial effort or training. A new resource that provides easy access to information about genes and their biological functions was just released by Cold Spring Harbor Laboratory Press.

12 Jan 2011

Plenty of breaks from sitting at the desk are good for hearts and waistlines: Study

It is becoming well accepted that, as well as too little exercise, too much sitting is bad for people's health. Now a new study has found that it is not just the length of time people spend sitting down that can make a difference, but also the number of breaks that they take while sitting at their desk or on their sofa. Plenty of breaks, even if they are as little as one minute, seem to be good for people's hearts and their waistlines.

12 Jan 2011

How chlamydia increases risk of ectopic pregnancy

Women who have had chlamydia are at greater risk of an ectopic pregnancy because of a lasting effect of the infection.

11 Jan 2011

BioScale announces results of two pharmacodynamic biomarkers using assay AMMP technology

BioScale, an innovative life science company that develops, manufactures and promotes novel analytical tools enabling advancements in protein research, announced that results from the analysis of two pharmacodynamic biomarkers using the Acoustic Membrane MicroParticles assay technology on the ViBE Protein Analysis Workstation were published in the peer-reviewed Elsevier Journal of Analytical Biochemistry.

11 Jan 2011

Study to identify early warning biomarkers for presence of breast and prostate cancers

Using biological samples taken from patients and state-of-the-art biochemical techniques, a Florida State University researcher is working to identify a variety of "biomarkers" that might provide earlier warnings of the presence of breast and prostate cancers.

11 Jan 2011

Research could lead to new approaches to treat dementia

A researcher at the University of Pittsburgh School of Medicine, in collaboration with scientists from the National Institutes of Health, has discovered that the deadly plaques of Alzheimer's disease interact with certain cellular proteins to inhibit normal signals that maintain blood flow to the brain.

11 Jan 2011

G Protein News and Research

Study supports use of PRX as an anti-cataract agent

Brain cell destroying genetic mechanism responsible for development of AD

7,8-Dihydroxyflavone holds potential for treatment of fear based disorders

TKM-PLK1 drug may offer hope for patients with advanced solid tumor cancers

New discovery has brought dream of transforming measles virus against cancer

Aβ, tau and Fyn protein interactions may lead to brain dysfunction and AD

Obesity in children today may contribute to 2-5 year decline in life expectancy

Micromet, MedImmune initiate MT111 Phase 1 trial in patients with advanced gastrointestinal cancer

Study indicates disease's underlying causes in mice, finds compounds that normalize Alzheimer's brain

Lipoprotein receptor LRP1 also regulates food intake and energy balance in central nervous system: Study

Offensive protein generated by HPV handicaps defensive protein made by the human body

Study shows delivering cancer drug in hydrophobic nanoparticle is a safe and effective prostate cancer therapy

Study reveals underlying causes for degeneration of synapses in Alzheimer's Disease

Scientists introduce DNA directly into cell nucleus using protein nanodisks

New database provides easy access to information about genes and biological functions

Plenty of breaks from sitting at the desk are good for hearts and waistlines: Study

How chlamydia increases risk of ectopic pregnancy

BioScale announces results of two pharmacodynamic biomarkers using assay AMMP technology

Study to identify early warning biomarkers for presence of breast and prostate cancers

Research could lead to new approaches to treat dementia

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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