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NanoString to begin clinical development program for Breast Cancer Intrinsic Subtyping Assay

NanoString Technologies, Inc., a privately held provider of life science tools for translational research and developer of molecular diagnostics, today announced that it is initiating the first in a series of studies to evaluate the clinical utility of the NanoString Breast Cancer Intrinsic Subtyping Assay.

From NanoString Technologies 4 Aug 2011

Innovative delivery systems and methods to treat breast cancer

In their lifetime, women have more than a 12 percent risk of being diagnosed with breast cancer. 1 This week, research on novel approaches to breast cancer treatment is being presented at the Era of Hope (EOH) conference, a scientific meeting hosted by the Department of Defense Breast Cancer Research Program (BCRP).

4 Aug 2011

Conference to discuss novel studies that address how inherited genes cause breast cancer

A woman's ethnicity as well as her genetic makeup are two of the main risk factors for hereditary breast cancer. Research into understanding and treating hereditary breast cancer will be presented today at the Era of Hope conference, a scientific meeting hosted by the Department of Defense Breast Cancer Research Program.

4 Aug 2011

ImmunoGen revenues increase to $19.3 million for fiscal year 2011

ImmunoGen, Inc., a biotechnology company that develops targeted anticancer products using its antibody expertise and Targeted Antibody Payload (TAP) technology, today reported financial results for the three-month period and fiscal year ended June 30, 2011.

4 Aug 2011

Researchers discover biological mechanism behind sarcopenia

Researchers at Columbia University Medical Center have discovered the biological mechanism behind age-related loss of muscle strength and identified a drug that may help reverse this process.

3 Aug 2011

New method of delivering growth factors could lead to revolutionary heart treatment

Ever since the Nobel Prize for nerve growth factor was awarded more than 30 years ago, researchers have been searching for ways to use growth factor clinically.

3 Aug 2011

Prolonged estrogen deprivation reduces ability to prevent strokes

Prolonged estrogen deprivation in aging rats dramatically reduces the number of brain receptors for the hormone as well as its ability to prevent strokes, researchers report.

3 Aug 2011

Combination molecules with BRAF inhibitors may help overcome drug resistance in melanoma patients

About 50 to 60 percent of patients with melanoma have a mutation in the BRAF gene that drives the growth of their cancer. Most of these patients respond well to two novel agents being studied in clinical trials that inhibit the gene, with remarkable responses that are, unfortunately, almost always limited in duration.

3 Aug 2011

GSK, NPS enter agreement to evaluate ronacaleret in new indications

NPS Pharmaceuticals, Inc., a specialty pharmaceutical company developing orphan therapeutics for rare gastrointestinal and endocrine disorders, today reported that it has entered into a new agreement with GlaxoSmithKline (GSK), that terminates and replaces a prior collaborative research and license agreement between NPS and GSK from 1993, which focused on the discovery and development of small molecule antagonists of the calcium receptor that increase secretion of parathyroid hormone.

3 Aug 2011

Lipid nanocarriers in cancer diagnosis and therapy: New book

This book introduces fundamental principles of lipid nanocarriers science relevant to cancer therapy. The first in this field, it fills a need for an accurate, coherent and authoritative introduction to lipid nanocarriers focusing in cancer therapy; both because of the growing popularity of these modern drug delivery systems and also because of the emergent need of dealing with cancer treatment.

2 Aug 2011

Lack of TLR1 surface expression linked with increased susceptibility to tuberculosis

Are you genetically predisposed to tuberculosis? Scientists may now be able to answer this question and doctors may be able to adjust their therapeutic approach based on what they learn. That's because new research presented in the Journal of Leukocyte Biology suggests that two frequent mutations in an immune system gene called TLR1 are responsible for cellular changes that ultimately make us less likely to resist the disease.

2 Aug 2011

Nicotine protects against Parkinson's disease

If you've ever wondered if smoking offered society any benefit, a new research report published in The FASEB Journal offers a surprising answer. Nicotine protects us from Parkinson's disease, and the discovery of how nicotine does this may lead to entirely new types of treatments for the disease.

2 Aug 2011

Blocking IGF-1 receptor cripples cancer growth in T cell acute lymphoblastic leukemia

Blocking a growth factor receptor cripples cancer growth in a form of T cell leukemia, according to a study published online on August 1 in the Journal of Experimental Medicine.

2 Aug 2011

Taxoxifen combined with dasatinib reverses chemo-resistance in breast cancer cells

Taking a leukemia chemotherapy drug may help breast cancer patients who don't respond to tamoxifen overcome resistance to the widely-used drug, new research from the Kimmel Cancer Center at Jefferson suggests.

2 Aug 2011

Researchers reveal molecular mechanisms responsible for organizing intestinal epithelium

How do cells know where to position themselves and where to accumulate in order to carry out their functions correctly within each organ? Researchers with the Colorectal Cancer Lab at IRB Barcelona have revealed the molecular mechanisms responsible for organizing the intestinal epithelium into distinct comportments, defined by frontiers or territories.

1 Aug 2011

Merck reports worldwide sales of $12.2 billion for second quarter 2011

Merck, known as MSD outside the United States and Canada, today announced financial results for the second quarter of 2011.

29 Jul 2011

'Systems biology' study of breast cancer

Using a "systems biology" approach - which focuses on understanding the complex relationships between biological systems - to look under the hood of an aggressive form of breast cancer, researchers for the first time have identified a set of proteins in the blood that change in abundance long before the cancer is clinically detectable.

29 Jul 2011

FDA issues Refusal to File letter for Eisai's perampanel NDA to treat partial-onset seizures

Eisai Inc. announced today that the U.S. Food and Drug Administration (FDA) has issued a Refusal to File letter in response to the company's New Drug Application (NDA) for perampanel (E2007), an investigational drug, for the treatment of partial-onset seizures associated with epilepsy which was submitted in May 2011.

29 Jul 2011

Amylin, Lilly and Alkermes submit reply to FDA complete response letter for BYDUREON

Amylin Pharmaceuticals, Inc., Eli Lilly and Company and Alkermes, Inc. today announced that the companies have submitted their reply to a complete response letter issued in October 2010 by the U.S. Food and Drug Administration (FDA) regarding BYDUREON™ (exenatide extended-release for injectable suspension), an investigational medication for type 2 diabetes.

28 Jul 2011

Scientists show how RET gene in breast cancer cells responds to estrogen

Using human breast cancer cells and the protein that causes fireflies to glow, a Johns Hopkins team has shed light on why some breast cancer cells become resistant to the anticancer effects of the drug tamoxifen. The key is a discovery of two genetic "dimmer switches" that apparently control how a breast cancer gene responds to the female hormone estrogen.

28 Jul 2011

Receptor News and Research

NanoString to begin clinical development program for Breast Cancer Intrinsic Subtyping Assay

Innovative delivery systems and methods to treat breast cancer

Conference to discuss novel studies that address how inherited genes cause breast cancer

ImmunoGen revenues increase to $19.3 million for fiscal year 2011

Researchers discover biological mechanism behind sarcopenia

New method of delivering growth factors could lead to revolutionary heart treatment

Prolonged estrogen deprivation reduces ability to prevent strokes

Combination molecules with BRAF inhibitors may help overcome drug resistance in melanoma patients

GSK, NPS enter agreement to evaluate ronacaleret in new indications

Lipid nanocarriers in cancer diagnosis and therapy: New book

Lack of TLR1 surface expression linked with increased susceptibility to tuberculosis

Nicotine protects against Parkinson's disease

Blocking IGF-1 receptor cripples cancer growth in T cell acute lymphoblastic leukemia

Taxoxifen combined with dasatinib reverses chemo-resistance in breast cancer cells

Researchers reveal molecular mechanisms responsible for organizing intestinal epithelium

Merck reports worldwide sales of $12.2 billion for second quarter 2011

'Systems biology' study of breast cancer

FDA issues Refusal to File letter for Eisai's perampanel NDA to treat partial-onset seizures

Amylin, Lilly and Alkermes submit reply to FDA complete response letter for BYDUREON

Scientists show how RET gene in breast cancer cells responds to estrogen

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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