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Scientists use genomics and bioinformatics to analyze blueprint of novel coronavirus

Australian researchers from the Commonwealth Scientific and Industrial Research Organization (CSIRO) have found a new way to decode the genome of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes COVID-19 disease. This approach could help in drug and vaccine development. Their work titled, "Supporting pandemic response using genomics and bioinformatics: a case study on the emergent SARS-CoV-2 outbreak," is published in the latest issue of the journal Transboundary and Emerging Diseases.

21 Apr 2020

COVID-19 and immunodeficiency

COVID-19 disease, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a highly infectious disease. As of today, over 170,000 people worldwide have succumbed to the infection. Reports have shown that some comorbidities and illnesses raise the risk of getting infected and also influence the severity of the disease. Having a compromised immune system can also drastically raise the risk of getting COVID-19.

21 Apr 2020

Does high COVID-19 viral load mean more risk of infection?

The risk of getting infected with COVID-19 disease is higher among healthcare workers who are in close contact with infected patients

21 Apr 2020

ACE2 receptor expression by SARS-CoV-2 across different animal species

A new report published on the preprint server bioRxiv in April 2020 reports that several species of animals can be infected with relative ease by the SARS-CoV-2 virus that is the causative agent of the currently raging COVID-19 pandemic. This casts much light on the possible natural hosts and routes of transmission of this virus.

20 Apr 2020

ATS publishes first official clinical practice guidelines for sarcoidosis

New guidance is available for physicians who must go through a number of steps to provide a probable diagnosis of sarcoidosis - an inflammatory disease that affects the lungs, lymph glands, and other organs.

20 Apr 2020

ACE2-TMPRSS2 profiling indicates tissue vulnerability to SARS-CoV-2 infection

A new study published in April 2020 on the preprint server bioRxiv reports that the different levels of susceptibility of various organs to viral attack by the SARS-CoV-2 virus causing the huge pandemic of COVID-19 sweeping around the world can be predicted from the level of expression of two molecules, the ACE2 receptor, and the TMPRSS2 protein.

20 Apr 2020

Antibody detection for COVID-19 - promise and risks

Recently, several research groups emphasized how the pervasive screening for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies may prove pivotal in determining infection seroprevalence in a given population defining previous exposure, screening health care workers, but also identifying highly reactive individuals that may act as donors for the therapeutic use of their convalescent serum.

20 Apr 2020

CRISPR technology mobilized for rapid COVID-19 diagnosis

A group of authors from the United States published a study in the scientific journal Nature Biotechnology in which they have described a CRISPR-Cas-based approach for rapid and accurate diagnosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection – without the need for complex laboratory infrastructure.

20 Apr 2020

Cost-effective plastic canopy system protects health workers at risk of airborne coronavirus infection

Researchers have designed a cost-effective, constant flow plastic canopy system that can help to protect healthcare workers who are at risk of airborne coronavirus infection while delivering non-invasive ventilation or oxygen via high flow nasal canula, according to a research letter published in the European Respiratory Journal.

20 Apr 2020

COVID-19 lung injury is not like high altitude pulmonary edema

A group of researchers with experience in treating high altitude pulmonary edema have written to correct the misconception in medical social media forums and elsewhere that the lung injury seen in COVID-19 is not like typical acute respiratory distress syndrome and is instead like HAPE.

20 Apr 2020

Penn Medicine launches convalescent plasma therapy trial for COVID-19 patients

Convalescent plasma therapy for COVID-19 patients -- an experimental approach of giving a transfusion of plasma collected from a donor who has recovered from COVID-19 to a patient with an active infection -- is the focus of a new two-part research initiative at Penn Medicine.

20 Apr 2020

New data supports role of nitrogen dioxide in the high number of Covid-19 deaths

Elevated levels of nitrogen dioxide in the air may be associated with a high number of deaths from Covid-19. A new study by Martin Luther University Halle-Wittenberg (MLU) provides concrete data that back this assumption for the first time.

20 Apr 2020

Wavelength Pharmaceuticals expands supplies of key drug ingredients for critically ill COVID-19 patients

Wavelength Pharmaceuticals, a leading supplier of active pharmaceutical ingredients, today reported that it has greatly expanded production of APIs for certain pharmaceutical products needed to manage respiratory critical care patients.

20 Apr 2020

How climate change is putting doctors in the hot seat

A 4-year-old girl was rushed to the emergency room three times in one week for asthma attacks.

20 Apr 2020

Remdesivir prevents COVID-19 progression to severe pneumonia, animal study shows

A team of scientists at the National Institute of Allergy and Infectious Diseases, which is part of the U.S. National Institutes of Health, has tested the efficacy of remdesivir, a nucleotide analog prodrug with a broad antiviral activity, as a COVID-19 treatment.

20 Apr 2020

Smoking doubles risk of severe COVID-19 disease

The fatality rate among infected people increases among the elderly and those with underlying medical conditions. Now, a new study published as a pre-print on medXriv, links smoking to the progression of COVID-19 disease, suggesting that the odds of disease progression is more than double in smokers.

20 Apr 2020

Poorer regions in the Philippines have more COVID-19 cases

The coronavirus disease (COVID-19) has dramatically affected European countries and the United States, reporting the highest number of confirmed cases. In Asia, though the number of infections gradually increases, some countries have reported high death rates, including Indonesia and the Philippines.

20 Apr 2020

Remote monitoring of COVID-19 patients using AI device

Massachusetts' Institute of Technology (MIT) at its Computer Science and Artificial Intelligence Laboratory (CSAIL) has developed a device that can monitor patients with the highly infective COVID-19 remotely and thus prevent the spread of the infection to healthcare workers.

19 Apr 2020

How are the interventions against COVID-19 working in Sweden?

In a new study, Swedish researchers speculate the effects of the present intervention strategies on the healthcare system as the COVID-19 pandemic affects the nation. Their study titled, “Intervention strategies against COVID-19 and their estimated impact on Swedish healthcare capacity,” has not been published yet; however, the findings are available as pre-peer-reviewed study at medRxiv.

19 Apr 2020

Novel coronavirus mutation could spell trouble for vaccine development

New research shows that the novel coronavirus is undergoing mutations that could make it challenging to develop a vaccine against. There are a few vaccine candidates that are in the making to prevent COVID-19. With a potential for mutation, the vaccines that are being developed now may not work against the emergent mutated strains worry Taiwanese and Australian researchers. The study is titled, “Analysis of the mutation dynamics of SARS-CoV-2 reveals the spread history and emergence of 2 RBD mutant with lower ACE2 binding affinity.”

19 Apr 2020