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Scientists identify molecule that could be targeted to prevent vision loss in diabetics and preterm infants

Researchers at Bascom Palmer Eye Institute, part of the University of Miami Miller School of Medicine, have identified a new molecule that induces the formation of abnormal blood vessels in the eyes of diabetic mice.

23 Mar 2017

Heroin use linked to epigenetic alterations in the brain

Heroin use is associated with excessive histone acetylation, an epigenetic process that regulates gene expression, and more years of drug use correlate with higher levels of hyperacetylation, according to research conducted at The Icahn School of Medicine at Mount Sinai and published in the journal Biological Psychiatry.

22 Mar 2017

USC study close to finding gene involved in cleft lip and palate

A group of researchers has found that three siblings born with cleft lip and palate share a common gene mutation associated with the birth defect.

22 Mar 2017

Scientists use parsley and other plants to create human stem cell scaffolds

Borrowing from nature is an age-old theme in science. Form and function go hand-in-hand in the natural world and the structures created by plants and animals are only rarely improved on by humans.

21 Mar 2017

Researchers use animal model to study brain abnormality in human TD patients

Thanatophoric dysplasia (TD) is an intractable disease designated by Ministry of Welfare, Health and Labor of Japan, causing severe abnormalities of bones and the brain.

17 Mar 2017

Researchers identify underlying cause of obsessive-compulsive disorder

An overactive molecular signal pathway in the brain region of the amygdala can lead to obsessive-compulsive disorder (OCD). A research team from Würzburg has established this connection.

16 Mar 2017

Heroin use linked to epigenetic alterations in the brain

The past few years have seen an explosion of heroin abuse and deaths from opiate overdose. But little is known about the molecular underpinnings of heroin addiction.

14 Mar 2017

Researchers discover cellular defects that underlie familial form of Parkinson's disease

Howard Hughes Medical Institute researchers have introduced a genetic mutation found in some patients with early onset Parkinson's disease into mice, creating a new animal model of the disease.

14 Mar 2017

Endostatin can decrease proliferation of castration-resistant prostate cancer cells

Failure of hormone deprivation therapy, which is used to slow prostate cancer in patients, leads to castration-resistant prostate cancer, a lethal form of advanced disease with limited treatment options.

10 Mar 2017

New research identifies signal that appears to trigger retinal regeneration in zebrafish

If you were a fish and your retina was damaged, it could repair itself and your vision would be restored in a few weeks.

10 Mar 2017

Study reveals promising new strategy to attack deadly pediatric brain tumor

Researchers from Northwestern Medicine and Ann & Robert H. Lurie Children's Hospital of Chicago have revealed new insight into how the most deadly pediatric brain tumor, diffuse intrinsic pontine glioma (DIPG), may develop.

7 Mar 2017

SLU study findings suggest new method to suppress LDL cholesterol

In a paper published in Biochemical Pharmacology, Saint Louis University researchers examined the way a nuclear receptor called REV-ERB is involved in regulating cholesterol metabolism.

6 Mar 2017

Researchers discover new way to develop painkillers without harmful side effects

Researchers from Charité - Universitätsmedizin Berlin have discovered a new way of developing painkillers.

3 Mar 2017

Neuroprotective compound could save brain cells during stroke, rat study shows

Researchers from the University of Iowa Carver College of Medicine and the University of Miami Miller School of Medicine have shown that a neuroprotective compound tested in rats provides two-pronged protection for brain cells during stroke and improves physical and cognitive outcomes in the treated animals.

2 Mar 2017

Scientists reveal new mRNA method to deliver safe, cost-effective therapeutic antibodies

Using antibodies to treat disease has been one of the great success stories of early 21st-century medicine. Already five of the ten top-selling pharmaceuticals in the United States are antibody products. But antibodies are large, complex proteins that can be expensive to manufacture.

2 Mar 2017

Researchers looking at ways to target lingering cancer stem cells that cause disease relapse

Chemotherapy treatment targets and kills cancer cells in the body. However, even after treatment, some cancer cells may remain in the patient's system undetected.

2 Mar 2017

Highly prevalent gene variants in African Americans contribute to kidney disease

African Americans have a heightened risk of developing chronic and end-stage kidney disease. This association has been attributed to two common genetic variants - named G1 and G2 -- in APOL1, a gene that codes for a human-specific protein.

1 Mar 2017

New PET radiotracer can quickly, non-invasively detect life-threatening atherosclerotic plaques

In the featured article of the March 2017 issue of "The Journal of Nuclear Medicine," researchers demonstrate that a new positron emission tomography radiotracer, gallium-68 (Ga-68)-pentixafor, can quickly and non-invasively identify life-threatening atherosclerotic plaques.

1 Mar 2017

Researchers develop testing program to study potency of vaccines for neglected tropical diseases

A new generation of vaccines for neglected tropical diseases is moving into clinical trials, and understanding the long-term stability and effectiveness of these vaccines over periods of storage is key to their success.

1 Mar 2017

New anti-cocaine monoclonal antibody moves forward towards clinical studies in humans

A University of Cincinnati researcher who has developed an immunotherapy to help reverse cocaine addiction that's been successful in animal models says he hopes to have it in clinical trials in human volunteers within a year.

28 Feb 2017

Animal Model News and Research

Scientists identify molecule that could be targeted to prevent vision loss in diabetics and preterm infants

Heroin use linked to epigenetic alterations in the brain

USC study close to finding gene involved in cleft lip and palate

Scientists use parsley and other plants to create human stem cell scaffolds

Researchers use animal model to study brain abnormality in human TD patients

Researchers identify underlying cause of obsessive-compulsive disorder

Heroin use linked to epigenetic alterations in the brain

Researchers discover cellular defects that underlie familial form of Parkinson's disease

Endostatin can decrease proliferation of castration-resistant prostate cancer cells

New research identifies signal that appears to trigger retinal regeneration in zebrafish

Study reveals promising new strategy to attack deadly pediatric brain tumor

SLU study findings suggest new method to suppress LDL cholesterol

Researchers discover new way to develop painkillers without harmful side effects

Neuroprotective compound could save brain cells during stroke, rat study shows

Scientists reveal new mRNA method to deliver safe, cost-effective therapeutic antibodies

Researchers looking at ways to target lingering cancer stem cells that cause disease relapse

Highly prevalent gene variants in African Americans contribute to kidney disease

New PET radiotracer can quickly, non-invasively detect life-threatening atherosclerotic plaques

Researchers develop testing program to study potency of vaccines for neglected tropical diseases

New anti-cocaine monoclonal antibody moves forward towards clinical studies in humans

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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