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Personalized medicine for breast cancer patients may be just around the corner

For breast cancer patients, the era of personalized medicine may be just around the corner, thanks to recent advances by USC Stem Cell researcher Min Yu and scientists at Massachusetts General Hospital and Harvard Medical School.

16 Jul 2014

Advanced Cell Diagnostics’ in situ hybridization technology reaches two major milestones

Advanced Cell Diagnostics Inc. (ACD), a leader in the field of molecular pathology and developer of cell and tissue-based analysis tools, has announced that its RNAscope® RNA in situ hybridization technology has reached two major milestones. In just three years, over 100 peer-reviewed papers featuring the technology have been published, and with the significant increase in use of RNAscope, ACD has now built a library of over 4000 target probes for numerous species. Probes are designed to order in under two weeks, and in just six months the library has grown by over 1500, reflecting the wide interest in ACD’s breakthrough technology.

From Advanced Cell Diagnostics 15 Jul 2014

Researchers develop new software to identify severity of cancer

Together with the company Tissuegnostics, the pathologist Lukas Kenner and his colleagues have developed a software that is able to identify cancer cells in tissue sections and demonstrate the presence of specific biomarkers on cells. The overall information provides a precise picture of the disease and leads to the most suitable treatment.

15 Jul 2014

New approach for developing personalized gene therapies to treat retinitis pigmentosa

Columbia University Medical Center researchers have created a way to develop personalized gene therapies for patients with retinitis pigmentosa (RP), a leading cause of vision loss.

11 Jul 2014

New diagnostic procedure helps differentiate psoriasis from eczema

In some patients, the chronic inflammatory skin diseases psoriasis* and eczema** are similar in appearance. Up to now, dermatologists have therefore had to base their decision on which treatment should be selected on their own experience and an examination of tissue samples.

10 Jul 2014

Pseudogenes may play key role in the discovery of new biomarkers

Dysfunctional, unloved and seemingly of little use, these poor-cousin relatives of genes have lost their protein-coding abilities. They contain material not essential for an organism's survival and are the "last stop" for removal of genomic waste.

8 Jul 2014

New collaborative fundraising effort focuses on AYA cancer

Leaders from Case Western Reserve University and University Hospitals this evening announced a new collaborative fundraising effort focused on Adolescent and Young Adult (AYA) cancer.

2 Jul 2014

Key historical misconceptions hinder research and treatment for brain metastases

"Key historical misconceptions" are hindering progress in research and treatment for patients with cancer metastases to the brain, suggests a special article in the July issue of Neurosurgery, official journal of the Congress of Neurological Surgeons.

25 Jun 2014

Definiens closes €15M financing round to expand into digital tissue diagnostics

Definiens AG, which offers a unique approach to tissue diagnostics aimed at helping physicians improve treatment, said that it has closed a round of financing for € 15 million.

23 Jun 2014

U of MD researchers to use $3.7 million NIH grant to develop novel method to treat monogenic diabetes

The National Institutes of Health has awarded a four-year, $3.7 million grant to researchers at the University of Maryland School of Medicine to develop a personalized medicine program to help doctors diagnose and treat monogenic diabetes - a form of diabetes caused by a mutation in a single gene.

19 Jun 2014

Researchers create three-dimensional complement of human retinal tissue in a dish

Using a type of human stem cell, Johns Hopkins researchers say they have created a three-dimensional complement of human retinal tissue in the laboratory, which notably includes functioning photoreceptor cells capable of responding to light, the first step in the process of converting it into visual images.

11 Jun 2014

Synthetic, Enterome partner to study effects of beta-lactam antibiotics on gastrointestinal microflora

Synthetic Biologics, Inc., a developer of novel anti-infective biologic and drug candidates targeting specific pathogens that cause serious infections and diseases, and Enterome Bioscience SA, a pioneer in the development of innovative disease management solutions based on a deep understanding of the gut microbiome, today announced that they have entered into an agreement to conduct metagenomic research on the effects of beta-lactam antibiotics on the gastrointestinal microflora (microbiome) of human patients.

10 Jun 2014

Research finding paves way for targeted approaches to treating cancer patients

Twelve years ago, UNC School of Medicine researcher Brian Strahl, PhD, found that a protein called Set2 plays a role in how yeast genes are expressed - specifically how DNA gets transcribed into messenger RNA. Now his lab has found that Set2 is also a major player in DNA repair, a complicated and crucial process that can lead to the development of cancer cells if the repair goes wrong.

9 Jun 2014

Scientists develop new molecule for monitoring drug concentration

Monitoring the drug concentration in patients is critical for effective treatment, especially in cases of cancer, heart disease, epilepsy and immunosuppression after organ transplants.

9 Jun 2014

New process to help select personalized treatment options for patients with lung adenocarcinoma

Moffitt Cancer Center researchers, in collaboration with the Lung Cancer Mutation Consortium, have developed a process to analyze mutated genes in lung adenocarcinoma to help better select personalized treatment options for patients.

4 Jun 2014

Men create more new proteins than women during interval training

When it comes to reaping benefits of sprint interval training, it appears that men have won the battle of the sexes, if just barely. According to new research published in the June 2014 issue of The FASEB Journal, men create more new proteins as a result of this exercise than women do.

3 Jun 2014

CHLA researchers develop novel NextGen sequencing approach for retinoblastoma

Researchers at Children's Hospital Los Angeles have developed a unique next-generation sequencing test for the gene linked to retinoblastoma. The new approach is both more comprehensive and can be conducted in less time than existing tests - enabling early detection of the cancer's genetic cause, which is critical for optimal treatment outcomes.

3 Jun 2014

Researchers create experimental blood test that determines BHI by gauging performance of mitochondria

Researchers at the University of Alabama at Birmingham School of Medicine have created an experimental blood test that, for the first time, determines a "Bioenergetic Health Index," or BHI, by gauging the performance of mitochondria, the cell's energy powerhouses.

30 May 2014

Blood gene expression profile identifies patients with elevated risk of cardiovascular death

A study of 338 patients with coronary artery disease has identified a gene expression profile associated with an elevated risk of cardiovascular death. Used with other indicators such as biochemical markers and family history, the profile - based on a simple blood test - may help identify patients who could benefit from personalized treatment and counseling designed to address risk factors.