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Preventative antibiotic given during labor can reduce the risk of sepsis and death

A single oral dose of the antibiotic azithromycin given during labor can dramatically reduce the risk of sepsis and death among women following childbirth, according to a large multi-country clinical trial, as a UN report warns of "stagnation" in maternal health.

23 Feb 2023

A study of the effects of beta-alanine supplements on soldiers' performance

Researchers review the effects of β-alanine supplementation on soldiers’ performance, cognition, and resilience.

22 Feb 2023

Scientists identify mechanisms underlying autoimmunity in Down syndrome

Scientists at the Icahn School of Medicine at Mount Sinai in New York have identified which parts of the immune system go awry and contribute to autoimmune diseases in individuals with Down syndrome.

22 Feb 2023

First clinical trial of GABA/GAD focused exclusively on children with recent onset Type 1 diabetes

For the first time, humans with newly diagnosed Type 1 diabetes, or T1D, have received two treatments called GABA and GAD that have shown promise in animal studies and in isolated human pancreas islets. This investigator-initiated clinical trial, published in Nature Communications, focused exclusively on children with recent onset T1D.

22 Feb 2023

A growing burden of alcoholic hepatitis

A recent study published in the journal Medical Clinics of North America discussed the diagnosis, treatment, and pathophysiology of alcoholic hepatitis (AH).

21 Feb 2023

Skin medication shows promise in treating alcohol use disorder

Researchers from Oregon Health & Science University and institutions across the country have identified a pill used to treat a common skin disease as an "incredibly promising" treatment for alcohol use disorder.

21 Feb 2023

Use of dapivirine vaginal ring during third trimester of pregnancy poses no safety concerns

A vaginal ring containing the antiretroviral drug dapivirine posed no safety concerns when used in the third trimester of pregnancy, according to results to date from the first study of the dapivirine ring during pregnancy and one of only a few studies of an HIV prevention product in pregnant cisgender women.

20 Feb 2023

Cannabidiol could help curb the urge for smoking cigarettes

Cannabidiol or CBD, a non-psychoactive component of cannabis, inhibits the metabolism of nicotine, new research has found, meaning it could help tobacco users curb the urge for that next cigarette.

16 Feb 2023

Nirmatrelvir-ritonavir therapy effective against Omicron BA.4/BA.5

Researchers examine non-hospitalized adult patients with COVID-19 treated with nirmatrelvir-ritonavir.

15 Feb 2023

What is the tolerability profile and rate of recurrent CDI after administrating microbiome therapeutic SER-109 post-antibiotic treatment?

Researchers investigated the tolerability and safety of a microbiome therapy called SER-109 to treat recurrent infections of Clostridioides difficile in adults.

15 Feb 2023

NIH initiates a clinical trial evaluating an investigational antiviral for treatment of COVID-19

The National Institutes of Health has initiated a multi-site clinical trial evaluating an investigational antiviral for the treatment of COVID-19.

15 Feb 2023

High doses of cannabidiol may increase the effects of THC in edible cannabis products

Contrary to some common claims, a study led by Johns Hopkins Medicine researchers found that relatively high doses of cannabidiol (CBD) may increase the adverse effects of delta-9-tetrahydrocannabinol (THC), the main active ingredient in cannabis that can cause a mood alteration or a "high" sensation.

13 Feb 2023

Neuroprotectant linked to reduced death and disability among stroke patients

The neuroprotectant ApTOLL, a medication that may shield the brain from tissue damage, was linked to reduced death and disability among people being treated for stroke when used with standard treatments to restore blood flow, according to preliminary late-breaking science presented today at the American Stroke Association's International Stroke Conference 2023.

13 Feb 2023

Declining PSA levels predict improved survival rates in men with non-metastatic castration-resistant prostate cancer

Declines in prostate-specific antigen (PSA) level after treatment with the next-generation androgen receptor inhibitor drug enzalutamide predict improved survival rates in men with non-metastatic castration-resistant prostate cancer (nmCRPC), reports The Journal of Urology, an Official Journal of the American Urological Association.

10 Feb 2023

Study: Single dose of common antibiotic given during labor reduces the risk of maternal death or sepsis

Sepsis - a severe infection in the body that can lead to tissue damage, organ failure, and death - is among the top causes of maternal deaths worldwide, according to the World Health Organization (WHO).

10 Feb 2023

Single dose of the antibiotic azithromycin decreases sepsis and death risk during childbirth

A single dose of the antibiotic azithromycin can help protect mothers from dangerous sepsis infections and death during vaginal childbirth, a sweeping new international study from a UVA Health scientist and his collaborators has found.

9 Feb 2023

Pegylated interferon lambda shows good efficacy against COVID-19

In a recent study published in The New England Journal of Medicine, researchers used the TOGETHER platform trial protocol to perform a phase III randomized controlled trial (RCT) to evaluate the effectiveness of pegylated interferon (IFN) lambda (λ) therapy in outpatients with coronavirus disease 2019 (COVID-19) in Canada and Brazil.

9 Feb 2023

Expert work group examines and redefines “clinical meaningfulness” in Alzheimer’s

As the Alzheimer's disease scientific community, patients, and families seek to understand the results of clinical trials of new Alzheimer's treatments, the Alzheimer's Association convened an expert work group to discuss an important and timely issue: the "clinical meaningfulness" of results from these studies.

7 Feb 2023

Men with low sexual desire might benefit from kisspeptin

A new study in the journal JAMA Network Open aimed to analyze the mechanistic and clinical effects of the administration of kisspeptin in men with HSDD.

7 Feb 2023

New Cochrane review: Taking vitamin D supplements does not reduce the risk of asthma attacks

Taking vitamin D supplements does not reduce the risk of asthma attacks in children or adults, according to an updated Cochrane review.

6 Feb 2023

Placebo News and Research

Preventative antibiotic given during labor can reduce the risk of sepsis and death

A study of the effects of beta-alanine supplements on soldiers' performance

Scientists identify mechanisms underlying autoimmunity in Down syndrome

First clinical trial of GABA/GAD focused exclusively on children with recent onset Type 1 diabetes

A growing burden of alcoholic hepatitis

Skin medication shows promise in treating alcohol use disorder

Use of dapivirine vaginal ring during third trimester of pregnancy poses no safety concerns

Cannabidiol could help curb the urge for smoking cigarettes

Nirmatrelvir-ritonavir therapy effective against Omicron BA.4/BA.5

What is the tolerability profile and rate of recurrent CDI after administrating microbiome therapeutic SER-109 post-antibiotic treatment?

NIH initiates a clinical trial evaluating an investigational antiviral for treatment of COVID-19

High doses of cannabidiol may increase the effects of THC in edible cannabis products

Neuroprotectant linked to reduced death and disability among stroke patients

Declining PSA levels predict improved survival rates in men with non-metastatic castration-resistant prostate cancer

Study: Single dose of common antibiotic given during labor reduces the risk of maternal death or sepsis

Single dose of the antibiotic azithromycin decreases sepsis and death risk during childbirth

Pegylated interferon lambda shows good efficacy against COVID-19

Expert work group examines and redefines “clinical meaningfulness” in Alzheimer’s

Men with low sexual desire might benefit from kisspeptin

New Cochrane review: Taking vitamin D supplements does not reduce the risk of asthma attacks

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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How Omics Technologies Are Transforming Biological Research and Drug Discovery

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