Proliferation News and Research

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AKT inhibitor miransertib could be a promising new treatment against low-flow vascular malformations

A team of researchers led by Dr. Sandra Castillo and Dr. Mariona Graupera, from the Josep Carreras Leukaemia Research Institute and member of the CIBERONC, have found the AKT inhibitor miransertib could be a new molecular treatment effective against low-flow vascular malformations, a long-awaited milestone.

14 Jun 2022

Targeting macropinocytosis may be an effective therapeutic approach for hepatocellular carcinoma

Researchers from the Department of Pathology, School of Clinical Medicine, LKS Faculty of Medicine, The University of Hong Kong (HKUMed) have identified a new metabolic mechanism in liver cancer cells, by which macropinocytosis, an endocytic process, is used to engulf extracellular proteins as fuels to support the unlimited growth of hepatocellular carcinoma (HCC) in hypoxia (oxygen deprivation).

14 Jun 2022

The potential role of Ginkgo biloba L. folium extract in the management of COVID-19

Researchers explored the effectiveness of Ginkgo biloba L. folium extract (EGb) in the management of COVID-19 severity.

13 Jun 2022

Potential applications of bioactive molecules present in fruit peels

A recent study published in Current Issues in Molecular Biology reviewed the potential biological applications of fruit peel extracts.

13 Jun 2022

Study reports robust immunity to SARS-CoV-2 including Omicron BA.1 for all three primary vaccines

In a recent study posted to the medRxiv* pre-print server, researchers in the United Kingdom investigated the effect of two Pfizer/BioNTech BNT162b2 vaccine doses or Oxford/AstraZeneca AZ1222 coronavirus disease 2019 (COVID-19) vaccination and a subsequent BNT162b2 booster dose in a cohort of healthcare workers (HCWs) over six to nine months.

10 Jun 2022

A comparison of SARS-CoV-2 and influenza cytokine storms

In a recent study published in the Journal of Interferon & Cytokine Research, researchers compared the cytokine storms of pandemic influenza and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections.

9 Jun 2022

Infiltrating gliomas are shaped by genetic evolution and microenvironment, finds study

Researchers have discovered that infiltrating gliomas, a common brain and spinal cord tumor, are shaped by their genetic evolution and microenvironment, a finding that could lead to more targeted treatments.

9 Jun 2022

Diet rich in polyphenols can prevent inflammation in the elderly

Polyphenols in the foods that we eat can prevent inflammation in older people, since they alter the intestinal microbiota and induce the production of the indole 3-propionic acid (IPA), a metabolite derived from the degradation of tryptophan due to intestinal bacteria.

8 Jun 2022

Irregularities in production of brain cells may lead to autism spectrum disorder, finds study

Analyzing brain stem cells of patients with autism spectrum disorder (ASD), Rutgers scientists have found evidence of irregularities in very early brain development that may contribute to the neuropsychiatric disorder.

8 Jun 2022

Cofilin could be a potential target for mitigating atherosclerosis at early stage, finds study

A joint research team at LKS Faculty of Medicine, The University of Hong Kong (HKUMed) and Queen Mary University of London (QMUL) has discovered the molecular mechanisms of how pathological condition-mimicking mechanical stimuli lead to the early progression of atherosclerosis, a leading cause of vascular disease worldwide.

8 Jun 2022

New immunotherapy mechanism can block spontaneous breast carcinogenesis

Researchers have discovered the mechanism by which specific immune cells can block breast cancer development and even suppress a developed tumor.

3 Jun 2022

Genetically engineered immune cells target cancer cells that may be responsible for leukemia relapse

Genetically engineered immune cells successfully target the specific cancer cells that may be responsible for relapse of acute myeloid leukemia (AML), a type of blood cancer, and proved effective in animal models of the disease, according to a preclinical study by investigators at Weill Cornell Medicine.

2 Jun 2022

New research may open a window to treating aggressive form of B-cell acute lymphoblastic leukemia

Survival has improved greatly in children with acute lymphocytic leukemia (ALL). But a certain form of ALL that occurs mostly in babies is still very lethal, with a survival rate below 50 percent: B-cell acute lymphoblastic leukemia with rearrangements of the mixed lineage leukemia gene, or MLL B-ALL.

1 Jun 2022

Study finds a link between aging and cancer metastases

Spreading cancer cells that escape a primary tumor site can seed in tissues distant from the tumor, but may take several years or decades to grow into full metastatic cancers.

1 Jun 2022

MGH scientists develop a data-driven simulation model to address the rampant opioid crisis

A data-driven simulation model designed to help policymakers to better understand and address the nation's rampant opioid crisis has been developed by a team of scientists at Massachusetts General Hospital.

31 May 2022

Vitamin D therapy may be a useful addition to the treatment of ovarian cancer, study suggests

Ovarian cancer has one of the highest death rates of all cancers. One reason for this is that cancer turns the body's defenses against itself. However, new research from Nagoya University published in Matrix Biology suggests that vitamin D can effectively prevent one of the key pathways used by this cancer.

30 May 2022

Discovery explains why patients with severe asthma are unresponsive to treatment

Patients with the most severe form of asthma produce special substances in their airways when taking medicine during an asthma attack that block the treatment from working, according to a study where Rutgers scientists collaborated with researchers at Genentech, a member of the Roche Group.

30 May 2022

Researchers report novel interactions between the SARS-CoV-2 S protein and estrogen receptor alpha

Researchers profiled the binding sites of the entire SARS-CoV-2 spike protein sequence.

26 May 2022

Study brings precision medicine closer to reality for diffuse large B cell lymphoma

DNA mutations are essential to the rapid development of an array of antibody-producing immune cells called B cells that collectively can recognize a vast number of specific targets.

25 May 2022

Biodegradable, non-ionic polymeric nanovesicles efficiently encapsulate and deliver siRNA

Small interfering RNAs, or siRNAs, hold promise to treat tumors, through their ability to specifically knock down oncogenes that promote tumor growth, without the toxicity that accompanies chemotherapy. However, the siRNAs need a delivery vehicle to protect them from degradation and clearance on their journey through the bloodstream to the cancer tumor.

25 May 2022

Proliferation News and Research

AKT inhibitor miransertib could be a promising new treatment against low-flow vascular malformations

Targeting macropinocytosis may be an effective therapeutic approach for hepatocellular carcinoma

The potential role of Ginkgo biloba L. folium extract in the management of COVID-19

Potential applications of bioactive molecules present in fruit peels

Study reports robust immunity to SARS-CoV-2 including Omicron BA.1 for all three primary vaccines

A comparison of SARS-CoV-2 and influenza cytokine storms

Infiltrating gliomas are shaped by genetic evolution and microenvironment, finds study

Diet rich in polyphenols can prevent inflammation in the elderly

Irregularities in production of brain cells may lead to autism spectrum disorder, finds study

Cofilin could be a potential target for mitigating atherosclerosis at early stage, finds study

New immunotherapy mechanism can block spontaneous breast carcinogenesis

Genetically engineered immune cells target cancer cells that may be responsible for leukemia relapse

New research may open a window to treating aggressive form of B-cell acute lymphoblastic leukemia

Study finds a link between aging and cancer metastases

MGH scientists develop a data-driven simulation model to address the rampant opioid crisis

Vitamin D therapy may be a useful addition to the treatment of ovarian cancer, study suggests

Discovery explains why patients with severe asthma are unresponsive to treatment

Researchers report novel interactions between the SARS-CoV-2 S protein and estrogen receptor alpha

Study brings precision medicine closer to reality for diffuse large B cell lymphoma

Biodegradable, non-ionic polymeric nanovesicles efficiently encapsulate and deliver siRNA

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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