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Gene mutation found in some women may decrease effectiveness of tamoxifen breast cancer drug

Researchers from the Johns Hopkins Kimmel Cancer Center, Indiana University and the University of Michigan have found that some women have a gene mutation that may decrease the effectiveness of tamoxifen, a commonly used breast cancer drug.

7 Jun 2004

Research may help treat muscular dystrophies and other muscle diseases caused by glycosylation defects

Expressing high levels of a sugar-adding protein known as LARGE in mice that lack the protein can prevent muscular dystrophy in these animals, according to studies by researchers at the University of Iowa Roy J. and Lucille A. Carver College of Medicine.

7 Jun 2004

Crucial discovery may help better diagnose and treat children with Hirschsprung disease

Researchers at Fox Chase Cancer Center have made a crucial discovery that may help physicians better diagnose and treat children with Hirschsprung disease, a debilitating and sometimes life-threatening ailment that causes bowel obstruction and involves an array of genetic changes.

5 Jun 2004

High school student makes significant contribution to breast cancer research

A high school student from Albany, New York, has made a significant contribution toward understanding how mutations to a gene called BRCA-1 contributes to hereditary breast cancer.

5 Jun 2004

Computational design used to engineer and construct a protein that could sense the nerve agent soman

Duke University Medical Center biochemists have used computational design to engineer and construct a protein that could sense the nerve agent soman. They said their achievement constitutes a proof-of principle that such engineered proteins can be made to detect nerve agents such as sarin and other toxic substances.

5 Jun 2004

Parkinson's disease breakthrough

Brandeis scientists have made groundbreaking advances in understanding how the regulations of a novel gene during the cell cycle can lead to a rare familial case of the early onset of Parkinson's disease.

5 Jun 2004

How we pass our genes to our children

An Oxford-led team of researchers has found out more about what happens during recombination, the process by which the genetic information you inherited from your mother and father is mixed up to make a sex chromosome to pass on to your offspring.

1 Jun 2004

Randomness in gene expression to lead to differences in people that are genetically identical

Experiments by Howard Hughes Medical Institute (HHMI) researchers have revealed it might be possible for randomness in gene expression to lead to differences in cells — or people, for that matter — that are genetically identical.

27 May 2004

Cigarette smoking linked to leukemia

Cigarette smoking has been linked to acute myelogenous leukemia, according to The Health Consequences of Smoking: A Report of the Surgeon General, released today.

27 May 2004

Bacteria found in the mouth can block the HIV virus

Certain strains of bacteria that occur naturally in the human mouth can snare the HIV virus and even cells it has infected, according to researchers at the University of Illinois at Chicago College of Dentistry. They report their findings today at the 104th General Meeting of the American Society for Microbiology.

25 May 2004

Researchers have identified the first gene linked to the productivity of the stem cells that produce sperm in mammals

Researchers have identified the first gene linked to the productivity of the stem cells that produce sperm in mammals. The discovery was made by applying the latest laboratory methods to a strain of mice restored from embryos frozen since the early 70s.

23 May 2004

Genome research sheds light on Bardet-Biedl syndrome

By comparing the genomes of an alga, a weed and humans, a team of researchers has identified a new gene behind Bardet-Biedl syndrome (BBS), a complex condition marked by learning disabilities, vision loss and obesity.

21 May 2004

Tumour suppressor gene family may be key to new colon cancer drugs

In the hunt for new cancer drug targets, scientists from the Johns Hopkins Kimmel Cancer Center and the Howard Hughes Medical Institute have discovered mutations in a family of genes linked to more than a quarter of colon cancers, as well as several other common cancers including breast and lung.

20 May 2004

Cell division can be halted in multiple ways, with implications for cancer

Brown University researchers have found that there are multiple independent ways to stop cell division, a phenomenon that prevents the spread of genetic mutation, which can make cells cancerous. Results of this research, along with an accompanying editorial, were published in the current issue of the journal Molecular Cell.

20 May 2004

Closer to understanding the function of a protein linked to an inherited form of the movement disorder dystonia

The protein, torsinA, is defective in patients with DYT1 dystonia, an inherited condition that causes uncontrollable movements in the limbs and torso. Learning what torsinA does could be an important step toward developing a treatment for the disorder.

19 May 2004

Discovery of the gene for Cornelia de Lange syndrome

An international team of researchers has discovered the gene for Cornelia de Lange syndrome, a disabling, multisystem genetic disease that affects an estimated one in 10,000 children. The finding is expected to lead to a genetic test, enabling rapid and definitive diagnosis of the syndrome, as well as prenatal testing for families who already have one child with the disease.

17 May 2004

Genetically engineered viruses may create new class of cancer therapies

A genetically engineered virus can selectively kill cancerous cells in the lung and colon while leaving healthy cells intact, according to new research published today in Cancer Research by William Wold and colleagues at Saint Louis University School of Medicine.

15 May 2004

Risk of artery plaques increased by use of HIV drugs

An Italian study has provided evidence that HIV drugs called protease inhibitors may increase the risk of artery "plaques."

15 May 2004

Particles in the air we breathe may pose genetic risks to humans

Particles in the air we breathe may pose genetic risks to humans and wildlife, according to new findings by researchers at McMaster University.

15 May 2004

3 people with drug-resistant HIV become first to undergo a new form of gene therapy

The idea is to use a modified form of HIV to deliver an "antisense" gene to the immune cells that HIV infects. This is integrated into the cells' genome, and stays there until a cell is infected. Then it is switched on, and produces RNA complementary to the "sense" RNA encoding a viral protein. In theory, the RNAs should bind together, blocking viral replication.

14 May 2004

Mutation News and Research

Gene mutation found in some women may decrease effectiveness of tamoxifen breast cancer drug

Research may help treat muscular dystrophies and other muscle diseases caused by glycosylation defects

Crucial discovery may help better diagnose and treat children with Hirschsprung disease

High school student makes significant contribution to breast cancer research

Computational design used to engineer and construct a protein that could sense the nerve agent soman

Parkinson's disease breakthrough

How we pass our genes to our children

Randomness in gene expression to lead to differences in people that are genetically identical

Cigarette smoking linked to leukemia

Bacteria found in the mouth can block the HIV virus

Researchers have identified the first gene linked to the productivity of the stem cells that produce sperm in mammals

Genome research sheds light on Bardet-Biedl syndrome

Tumour suppressor gene family may be key to new colon cancer drugs

Cell division can be halted in multiple ways, with implications for cancer

Closer to understanding the function of a protein linked to an inherited form of the movement disorder dystonia

Discovery of the gene for Cornelia de Lange syndrome

Genetically engineered viruses may create new class of cancer therapies

Risk of artery plaques increased by use of HIV drugs

Particles in the air we breathe may pose genetic risks to humans

3 people with drug-resistant HIV become first to undergo a new form of gene therapy

Why use light scattering to analyze proteins and viral vectors?

Changing the landscape of R&D to build clinical success from the ground up

Sensing a Healthier Future

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