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Dasatinib offers new options for leukemia patients

Dasatinib, an experimental drug under development by Bristol-Myers Squibb, reverses the signs and symptoms of patients whose chronic myeloid leukemia has failed to respond to Gleevec, which is considered the standard of treatment for the disorder.

14 Jun 2006

Chickens may be silent carriers of bird flu

Health officials are on alert again in Hong Kong following reports of a suspected case of bird flu just over the border with China in Shenzhen.

14 Jun 2006

Mechanism for neurodenegerative diseases linked to transport proteins

Hampering the transport of proteins within cells may underlie several adult-onset neurodegenerative diseases, such as Huntington's, ALS and Kennedy disease. Understanding how this cell transport is blocked in these diseases may offer targets for future therapy.

9 Jun 2006

"Mechanistic basis for understanding why we treat symptoms"

In the 1990s, the notion of "six degrees of separation" emphasized human linkages that connected people around the world.

9 Jun 2006

Have we got it right about bird flu?

Health officials in Indonesia must have breathed a sigh of relief at the the World Health Organisation's (WHO) news that bird flu has been ruled out in the cases of four Indonesian nurses who fell sick after caring for people infected with H5N1 virus.

8 Jun 2006

Black women twice as likely to get aggressive breast cancer

New research has found that African-American women who contract breast cancer before reaching menopause are more than twice as likely as white women to have an aggressive, deadlier form of the disease.

8 Jun 2006

Black women twice as likely to get aggressive breast cancer

7 Jun 2006

Prophylactic surgery reduces the incidence of ovarian and related cancers

A new multicenter study is the first to suggest that the prophylactic removal of the ovaries and fallopian tubes may provide a different benefit for women who carry a genetic mutation in the BRCA2 gene than for those who have a BRCA1 genetic mutation.

7 Jun 2006

Gene mutation potentially involved in breast cancer initiation

Researchers have found evidence suggesting that a mutation in a gene that normally helps block the formation of breast tumors could play a role in the initiation of a major form of breast cancer.

6 Jun 2006

Hormonal treatments reduce risk of cancer returning

Women diagnosed with breast cancer who carry a certain genetic mutation can have breast-sparing surgery but should consider hormonal treatments to reduce their risk of cancer returning.

6 Jun 2006

Indonesia struggling to cope - quake survivors at greater risk of bird flu

Indonesia's devastating earthquake on 27 May, has so far taken the lives of over 6,000 people and injured 30,000 more.

6 Jun 2006

Men have a biological clock too and produce poor quality sperm as they age

Researchers in the U.S. say that even though men are able to father children well into old age, the quality of the sperm declines as men age.

6 Jun 2006

Study confirms Gleevec's long-term benefits in treating advanced gastrointestinal stromal tumors

People with advanced gastrointestinal stromal tumors (GIST) who take Gleevec (imatinib) for prolonged periods continue to benefit from the drug, according to a five-year study by Oregon Health & Science University Cancer Institute researchers.

6 Jun 2006

Sunitinib therapy shows promise in children with metastatic gastrointenstinal stromal tumor

Children with a rare digestive-tract cancer that is resistant to front-line therapy have benefited from a newer targeted therapy that has been shown effective in adults, according to data from a small pilot study.

5 Jun 2006

Migrating wild birds play a key role in transporting highly pathogenic avian influenza

Migrating wild birds have played and will likely continue to play a role in transporting highly pathogenic avian influenza (HPAI) virus, or bird flu, over long distances.

5 Jun 2006

Indonesian bird flu death toll now up to 37

Confirmation by the World Health Organization that a 15-year-old boy who died in West Java, Indonesia last week, was the latest bird flu victim, takes Indonesia's confirmed deaths from the virus to 37.

4 Jun 2006

Siblings deaths may indicate another bird flu cluster in Indonesia

According to an Indonesian health ministry official, a 7-year-old Indonesian girl who died last week has tested positive for bird flu in local tests; the results have yet to be confirmed by a World Health Organisation-accredited laboratory in Hong Kong.

4 Jun 2006

Pituitary adenoma predisposition caused by germline mutations in the AIP gene

A recent Finnish study identifies a low-penetrance gene defect which predisposes carriers to intracranial tumors called pituitary adenomas. In particular individuals carrying the gene defect are susceptible to such tumors which secrete growth hormone.

1 Jun 2006

Cause of neurodegeneration in Huntington's disease discovered

The severe neurodegeneration associated with Huntington's disease may result from molecular mutations that block the transport of nutrients within cells.

1 Jun 2006

Finding opens new pathways for treating or preventing autoimmune diseases

A rare genetic defect that can trigger a host of diseases from type 1 diabetes to alopecia has helped explain the imbalance of immune regulator and killer cells in autoimmune disease.

31 May 2006