Antiretroviral News and Research

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First Edition: December 2, 2011

In today's headlines, reports on congressional efforts to extend a payroll tax break and other work Congress must do before the end of the year -- including the Medicare doc fix.

2 Dec 2011

Mylan's NDA for Atazanavir Sulfate and Ritonavir Tablets receives tentative FDA approval through PEPFAR

Mylan Inc. today announced that its subsidiary Mylan Laboratories Limited has received tentative approval from the U.S. Food and Drug Administration through the President's Emergency Plan for AIDS Relief (PEPFAR) for its New Drug Application for Atazanavir Sulfate and Ritonavir Tablets, 300 mg/100 mg.

2 Dec 2011

U.S. global AIDS funding faces up to 10% cuts in fiscal 2012

As we approach World AIDS Day, life-saving funding is under attack from multiple fronts, and it couldn't come at a worse time. One of the world's biggest donors, the Global Fund to Fight AIDS, TB and Malaria canceled its next round of funding, because it couldn't secure enough donations.

2 Dec 2011

Obama renews U.S. commitment to ending AIDS in World AIDS Day speech

President Barack Obama on Thursday renewed the U.S. commitment to ending HIV/AIDS in a speech marking World AIDS Day, and was joined by former presidents Bill Clinton, who participated by video, and George W. Bush, who spoke from Tanzania with that country's President, Jakaya Kikwete, the Independent reports.

2 Dec 2011

Cheaper test as effective as a more sophisticated test in guiding anti-retroviral drug treatment

A cheaper laboratory test that helps guide anti-retroviral drug treatment for people with HIV/AIDS may be just as effective as a more sophisticated test, a group of international researchers has found - a discovery that could be particularly important in rural Africa.

2 Dec 2011

Xinhua examines HIV/AIDS in China

Xinhua posted several articles examining HIV/AIDS in China. The first looks at HIV/AIDS among the general population. The article notes that 346,000 people are living with HIV in China, and the "number is predicted to hit 780,000 by the end of 2011, according to an expert panel ... consisting of members from China's Ministry of Health (MOH), the World Health Organization and UNAIDS," the MOH reported in a statement released on Tuesday.

1 Dec 2011

Treatment cost savings under PEPFAR can be re-invested to increase ARV reach

In this post in the "Health Affairs Blog," Matthew Kavanagh, director of U.S. policy and advocacy at Health Global Access Project (GAP), and Marguerite Thorp, a research assistant at Harvard Medical School, examine how HIV/AIDS treatment funding under PEPFAR has "fallen significantly since 2008 in both absolute dollars and as a portion of total budgets -- just at a pivotal moment when investment could change the course of the epidemic."

1 Dec 2011

Scripps scientist receives NIH grant for HIV/AIDS research

A scientist at The Scripps Research Institute has been awarded $3.4 million from the National Institutes of Health to study the mode of action and the therapeutic potential of a new compound that blocks a step of HIV replication not targeted by current therapies.

1 Dec 2011

Political will, strong leadership from U.S. needed to end AIDS epidemic

"This Thursday's commemoration of World AIDS Day marks a potential turning point in the fight against a global epidemic that has yet to be arrested," a Detroit Free Press editorial states.

30 Nov 2011

Global leaders plan next steps at Harvard on World AIDS Day

Thirty years, 30 million deaths and 60 million infections after HIV appeared, medical researchers now have the tools to halt the deadly epidemic. "We have the weapons to win the war against AIDS," says Richard Marlink, M.D., Executive Director of the AIDS Initiative at the Harvard School of Public Health. "It is time to take what we have learned to turn the epidemic around and end AIDS."

30 Nov 2011

Testing of vaginal gel for HIV prevention halted after interim results showed no difference from placebo

Researchers involved with a multi-armed clinical trial designed to evaluate different antiretroviral (ARV) interventions for HIV prevention on Friday announced the arm testing a vaginal gel had been stopped because it was not working, the New York Times reports.

29 Nov 2011

VOICE continues testing daily use of ARV Truvada among women in sub-Saharan Africa

VOICE, an HIV prevention trial that has been evaluating two antiretroviral (ARV)-based approaches for preventing the sexual transmission of HIV in women - daily use of one of two different ARV tablets or of a vaginal gel - has stopped testing the gel.

29 Nov 2011

Obama should announce scale-up of AIDS treatment programs

Secretary of State Hillary Clinton's recent speech calling for an "AIDS-free generation" through the use of multiple prevention strategies, including more widespread antiretroviral therapy, "was a dramatic reversal of U.S. policy, which has historically viewed treatment more as a costly expense rather than our most powerful prevention investment," physician Loretta Ciraldo and Katrina Ciraldo, a student at Boston University School of Medicine, write in this Miami Herald opinion piece.

24 Nov 2011

Fight against HIV/AIDS continues with successes and failures: UNAIDS report

An annual report released Monday by UNAIDS, the United Nations agency fighting AIDS has revealed that the world’s AIDS epidemic has hit a plateau, with 2.7 million people becoming newly infected each year for the last five years.

22 Nov 2011

PEPFAR Scientific Advisory Board report offers six recommended research priorities

This post in the Center for Global Health Policy's "Science Speaks" blog examines a report by the PEPFAR Scientific Advisory Board (SAB) that offers six recommended treatment and prevention research priorities to U.S. Global AIDS Ambassador Eric Goosby and the Office of the Global AIDS Coordinator (OGAC) to guide future PEPFAR programs.

19 Nov 2011

HVTN debunks top 10 myths about HIV vaccine research

Dec. 1 is World AIDS Day, and in commemoration of the occasion, the HIV Vaccine Trials Network, headquartered at Fred Hutchinson Cancer Research Center, debunks the top 10 myths about HIV vaccine research.

18 Nov 2011

PlusNews examines shortages of HIV treatment supplies in Swaziland

PlusNews examines Swaziland's national shortages of antiretroviral (ARV) stocks, HIV tests, and lab tests necessary to initiate and manage HIV patients on treatment, and the country's efforts to find funding to prevent stock-outs of these supplies.

17 Nov 2011

First clinical trial of dapivirine-maraviroc ring to treat HIV in women

In the first clinical trial of a vaginal ring combining two antiretroviral (ARV) drugs, researchers from the Microbicide Trials Network (MTN) are collaborating with the International Partnership for Microbicides (IPM) to evaluate whether the ring is safe for use in women.

16 Nov 2011

Experts discuss treatment as prevention at USAID-, World Bank-sponsored debate

In this post in the Center for Global Development's "Global Health Policy" blog, Amanda Glassman, director of Global Health Policy and a research fellow at the center, reports on last week's USAID- and World Bank-sponsored debate on treatment as prevention, "where debaters were asked to support or oppose the proposition that countries should spend the majority of flat or declining HIV prevention budgets on 'treatment as prevention,' building off the results of the HPTN 052 study which found a relative reduction of 89 percent in the total number of HIV-1 transmissions resulting from the early initiation of antiretroviral therapy.

15 Nov 2011

Increased access to PMTCT needed to end pediatric AIDS, build an 'AIDS-free generation'

In this post in the Huffington Post's "Impact" blog, Charles Lyons, president and CEO of the Elizabeth Glaser Pediatric AIDS Foundation, responds to Secretary of State Hillary Clinton's speech at the NIH last week in which she called for an "AIDS-free generation," writing, "As Secretary Clinton pointed out, we've never before had as many tools to get ahead of the disease as we do now," such as male circumcision and treatment as prevention, "but one of the cornerstones of her strategy to create an AIDS-free generation is a tool we've actually had in our arsenal for a long time: the ability to prevent mother-to-child transmission of HIV."

14 Nov 2011