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Inhaled recombinant IL-15 tested in pet dogs with metastatic lung disease from osteosarcoma or melanoma

A protein that the body naturally produces could become an important new immunotherapy drug in the cache of cancer-fighting tools available to oncologists.

9 Jun 2022

Study shines new light on the role of key Parkinson’s disease protein

One of the hallmarks of Parkinson's disease (PD) is the accumulation in the brain of a protein known as alpha-synuclein. For more than two decades, alpha-synuclein has been a focal point of attention for researchers, clinicians and drug makers interested in PD.

9 Jun 2022

Advanced microscopy techniques offer detailed insight into inner workings of cells' powerhouses

Using advanced microscopy techniques, researchers at Karolinska Institutet and Stockholm University in Sweden have visualized in unprecedented detail the machinery that the cells' powerhouses, the mitochondria, use to form their proteins.

8 Jun 2022

Researchers develop new chemical-only process for creating customized mRNA vaccines

Researchers at Nagoya University in Japan have developed a new chemical-only process that may represent an important breakthrough in creating customized mRNA vaccines for a variety of diseases and allow for the inexpensive preparation of mRNA in large quantities.

8 Jun 2022

Ketogenic diets may help ward off polycystic kidney disease

The team of UC Santa Barbara biochemist Thomas Weimbs published the results of a clinical study that gives the first indication that ketogenic diets may be safe and effective in patients with polycystic kidney disease (PKD).

7 Jun 2022

New nanoparticles may pave the way for development of clinical sepsis therapy

Sepsis, the body's overreaction to an infection, affects more than 1.5 million people and kills at least 270,000 every year in the U.S. alone.

6 Jun 2022

Brain motor and fear circuits orchestrate the immune response to acute stress

A new study explores how acute stressors affected mice in terms of their immune responses in specific regions of the brain.

2 Jun 2022

New compound shows promise to kill a range of hard-to-treat cancer types

A compound, developed by a team including scientists from The University of Texas Health Science Center at San Antonio, kills a range of hard-to-treat cancer types in petri dishes and animal models by targeting a previously unexploited vulnerability, a new study reports.

2 Jun 2022

Immune modulator drugs improved clinical status, reduced deaths among patients hospitalized with COVID-19

A large randomized, placebo-controlled clinical trial led by the National Institutes of Health shows that treating adults hospitalized with COVID-19 with infliximab or abatacept - drugs widely used to treat certain autoimmune diseases - did not significantly shorten time to recovery but did substantially improve clinical status and reduce deaths.

2 Jun 2022

Ultrasound localization microscopy can image microscopic vessels and measure blood flow in the brain

To image microscopic vessels and measure blood flow in the brain, researchers use a tool called ultrasound localization microscopy. It works by using microscopic bubbles circulated through the bloodstream as a contrast agent to measure the reflection of high-frequency acoustic waves passing through the body.

1 Jun 2022

First-of-its-kind platform generates antitumor immunity and improves responses to checkpoint inhibitors

Researchers at The University of Texas MD Anderson Cancer Center have developed an ultrasound-guided cancer immunotherapy platform that generates systemic antitumor immunity and improves the therapeutic efficacy of immune checkpoint blockade.

30 May 2022

The role of pyroptosis in COVID-19

Researchers investigate the mechanisms by which SARS-CoV-2 induces NLRP3 inflammasome formation leading to pyroptosis.

25 May 2022

Study unveils the novel driver of cardiomyocyte loss

Researchers from the group of Eva van Rooij used advanced sequencing technology to better understand the heart disease arrhythmogenic cardiomyopathy, in which heart muscle tissue is replaced by fat cells. Using explanted human hearts, they found regions in which heart muscle was actively degenerated and identified a new gene, ZBTB11, that drives heart muscle cell degradation. The results were published in Cardiovascular Research on 17 May 2022.

25 May 2022

Repurposed drug clofoctol blocks SARS-CoV-2 replication in mouse study

A new paper presents the results of a mouse study using the repurposed antibacterial drug clofoctol against this virus.

23 May 2022

Researchers discover how one type of T cell creates functionally distinct, but genetically identical daughter cells

Scientists at St. Jude Children's Research Hospital have solved an immunology puzzle. A CD8+ T cell can have two functionally distinct daughter cells after it divides, despite the cells being genetically identical.

20 May 2022

Study demonstrates how the transcription factor C/EBPβ can positively influence fat storage

The chronic nutritional and metabolic disease of obesity is characterized by an excessive increase in body fat and its accumulation in tissues.

20 May 2022

Study finds gender-based disparity in life-saving TXA treatment

Injured women are half as likely as men to receive the life-saving drug tranexamic acid (TXA) even though the treatment is equally effective regardless of sex, according to new research in the British Journal of Anaesthesia.

19 May 2022

RNA binding-induced structural dynamics of SARS-CoV-2 nucleocapsid protein

Researchers predict structure models of the full-length SARS-CoV-2 N protein in both the presence and absence of RNA.

19 May 2022

Scientists use machine learning models to help discern characteristics of people with long-COVID

Clinical scientists used machine learning (ML) models to explore de-identified electronic health record (EHR) data in the National COVID Cohort Collaborative (N3C), a National Institutes of Health-funded national clinical database, to help discern characteristics of people with long-COVID and factors that may help identify such patients using data from medical records.

17 May 2022

Scientists use machine learning techniques for better characterization of long COVID

A research team supported by the National Institutes of Health has identified characteristics of people with long COVID and those likely to have it.

16 May 2022

Translation News and Research

Inhaled recombinant IL-15 tested in pet dogs with metastatic lung disease from osteosarcoma or melanoma

Study shines new light on the role of key Parkinson’s disease protein

Advanced microscopy techniques offer detailed insight into inner workings of cells' powerhouses

Researchers develop new chemical-only process for creating customized mRNA vaccines

Ketogenic diets may help ward off polycystic kidney disease

New nanoparticles may pave the way for development of clinical sepsis therapy

Brain motor and fear circuits orchestrate the immune response to acute stress

New compound shows promise to kill a range of hard-to-treat cancer types

Immune modulator drugs improved clinical status, reduced deaths among patients hospitalized with COVID-19

Ultrasound localization microscopy can image microscopic vessels and measure blood flow in the brain

First-of-its-kind platform generates antitumor immunity and improves responses to checkpoint inhibitors

The role of pyroptosis in COVID-19

Study unveils the novel driver of cardiomyocyte loss

Repurposed drug clofoctol blocks SARS-CoV-2 replication in mouse study

Researchers discover how one type of T cell creates functionally distinct, but genetically identical daughter cells

Study demonstrates how the transcription factor C/EBPβ can positively influence fat storage

Study finds gender-based disparity in life-saving TXA treatment

RNA binding-induced structural dynamics of SARS-CoV-2 nucleocapsid protein

Scientists use machine learning models to help discern characteristics of people with long-COVID

Scientists use machine learning techniques for better characterization of long COVID

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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