Mutation News and Research

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Non-BRCA1/2 hereditary breast cancer linked to new cancers

The risk for a new cancer in the unaffected breast substantially increases in women diagnosed with unilateral, hereditary (non-BRCA1/2) breast cancer, according to a new study by researchers working at Karolinska Institutet in Stockholm, Sweden.

14 Feb 2006

Nigeria struggling to cope with bird flu and more scares in Europe

The lethal strain of H5N1 bird flu has now reached Nigeria and there is concern as officials there in their efforts to prevent any human infections are having difficulty convincing many poor people not to eat dead poultry.

14 Feb 2006

Genzyme launches test to monitor Gleevec resistance

Genzyme Corporation has announced the availability of an important new test to monitor drug resistance in chronic myeloid leukemia (CML) patients who are treated with Gleevec (imatinib mesylate).

13 Feb 2006

Cellular discovery suggests possibilities for drug therapy for kidney disease

Scientists at the University of California, Santa Barbara have reported a discovery at the cellular level that suggests possibilities for drug therapy for kidney disease.

13 Feb 2006

Gene mutation discovered that causes a rare form of Charcot-Marie-Tooth disease

A multi-national research team that includes a Saint Louis University neurologist has discovered a gene mutation that causes a rare form of Charcot-Marie-Tooth disease, an inherited progressive nerve disorder. The findings are published in an advance online issue of Nature Genetics

13 Feb 2006

Common genetic variation increases SIDS risk in African Americans

About five percent of deaths from SIDS (sudden infant death syndrome) in African Americans can be traced to defects in one gene and half of those deaths result from a common genetic variation that increases an infant's risk of developing an abnormal heart rhythm during times of environmental stress

13 Feb 2006

Changes in the tissue environment of the breast that occur after pregnancy promote the metastasis of breast tumor cells

Changes in the tissue environment of the breast that occur after pregnancy promote the metastasis of breast tumor cells. The paper by McDaniel et al., "Remodeling of the mammary microenvironment following lactation promotes breast tumor cell metastasis.

12 Feb 2006

Duke University biologists evolve complex trait in the laboratory

Duke University biologists have evolved a complex trait in the laboratory -- using the pressure of selection to induce tobacco hornworms to evolve the dual trait of turning black or green depending on the temperature during their development.

12 Feb 2006

Bird flu found in wild birds in Greece, Italy and Bulgaria

According to European officials, the deadly H5N1 bird flu virus has been found in wild birds in Italy and Greece, and in Bulgaria.

12 Feb 2006

Alzheimer's disease appears to be highly heritable

In a large study of twins, Alzheimer's disease appears to be highly heritable and genetic factors may also influence timing of the disease, according to an article in the February Archives of General Psychiatry.

9 Feb 2006

Cancer researchers find evolutionary change that occurred in a key developmental signalling pathway

Cancer researchers at the University of Helsinki, in trying to find a novel tumor suppressor gene, instead found an important evolutionary change that occurred in a key developmental signalling pathway. The finding suggests a potential mechanism for evolution of complex intercellular signalling pathways.

9 Feb 2006

Researchers find new mechanism potentially explaining evolution of signalling pathways

7 Feb 2006

Viruses can be forced to evolve in ways to benefit humans

Viruses and humans have evolved together over millions of years in a game of one-upmanship that, often as not, left humans sick or worse.

7 Feb 2006

Discovery of the molecular mechanism that inhibits HCV replication in vitro

Since its discovery several decades ago, the insidious human pathogen has stymied the quest for anti-viral therapies by refusing to reproduce in test tubes for more than a few hours or days, denying scientists an efficient virus production and infection system for experimental research.

7 Feb 2006

Biochemists detect subtle new gyration that protein molecules undergo

Biochemists have detected a surprising, subtle new gyration that protein molecules undergo in the intricate, squirming dance that influences their activity in the cell.

7 Feb 2006

Common cardiac sodium channel variant associated with sudden infant death in African Americans

Steve A.N. Goldstein and colleagues from the Pritzker School of Medicine in Chicago have found that a specific mutation, called S1103Y, in a heart protein known as SCN5A is associated with a dramatic, 24-fold increased risk of sudden infant death syndrome (SIDS) in African American infants.

7 Feb 2006

New insight into one of the fundamental features of evolution

By experimentally promoting rapid, small-scale evolution within a lab population of yeast, researchers have shed light on the kinds of genetic changes that may underlie the emergence of new species.

7 Feb 2006

Abraham Lincoln may have suffered from movement disorder

Researchers at Johns Hopkins and the University of Minnesota have discovered a gene mutation in the descendants of Abraham Lincoln's grandparents that suggests the Civil War president himself might have also suffered from a disease that destroys nerve cells in the cerebellum-- the part of the brain that controls movement.

7 Feb 2006

Scientists have determined the detailed structure of an essential piece of the telomerase enzyme

Scientists have determined the detailed structure of an essential piece of the telomerase enzyme, an important contributor to the vast majority of human cancers. Understanding the physical shape of the protein has led to a better understanding of how it acts to immortalize cells - and should help scientists design broadly effective cancer drugs.

5 Feb 2006