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Scientists report promising activity of novel targeted drug in patients with advanced kidney cancer

Scientists report promising activity of a novel drug that targets a key molecular driver of clear cell renal cell carcinoma (ccRCC) in patients with metastatic disease.

13 Feb 2020

Acid reflux drug may be a promising therapy to reduce preterm birth

Lansoprazole, an over-the-counter acid reflux drug that is often taken by pregnant women, may be a promising therapy to reduce preterm birth, according to a computational drug repurposing study that also tested several of the drugs in mice.

13 Feb 2020

A143T variant of the GLA gene likely to cause late-onset Fabry cardiomyopathy

The A143T variant of the GLA gene is associated with an increased risk of Fabry cardiomyopathy, according to a new study.

13 Feb 2020

Macrophages consult with neighbors before making decisions

Many people consult their friends and neighbors before making a big decision. It turns out that cells also are consulting their neighbors in the human body.

13 Feb 2020

Study highlights trends in hospitalization, outcomes among veterans with critical limb ischemia

Between 2005 and 2014, the number of veterans who were hospitalized, required amputation or died due to critical blockages in leg arteries declined, according to new research published today in Circulation: Cardiovascular Interventions, a journal of the American Heart Association.

13 Feb 2020

No quick fix: Missouri finds managing pain without opioids isn’t fast or easy

Missouri began offering chiropractic care, acupuncture, physical therapy and cognitive-behavioral therapy for Medicaid patients in April, the latest state to try an alternative to opioids for those battling chronic pain.

13 Feb 2020

To fight Chinese outbreak, doctors deploy drugs targeting HIV, malaria and Ebola

As the scientific community scrambles to find a drug that can effectively treat tens of thousands of patients sickened by a new respiratory virus, they are trying some surprising remedies: medicines targeting known killers like HIV, Ebola and malaria.

13 Feb 2020

P53-deficient oral cancers recruit and reprogram nerves to fuel tumor growth

Loss of an important tumor-suppressing gene allows head and neck cancer to spin off signals to nearby nerves, changing their function and recruiting them to the tumor, where they fuel growth and cancer progression, researchers from The University of Texas MD Anderson Cancer Center report in the journal Nature today.

13 Feb 2020

Medicines for All Institute partners with South African manufacturer to increase access to lifesaving drugs

The Medicines for All Institute has entered into a partnership with a manufacturer in South Africa to commercialize advances made by the institute to improve access to lifesaving medications for HIV/AIDS and other diseases.

13 Feb 2020

Novel drug combination discovered to induce high rates of human beta cell proliferation

Researchers at the Icahn School of Medicine at Mount Sinai have discovered a novel combination of two classes of drugs that, together, cause the highest rate of proliferation ever observed in adult human beta cells- the cells in the pancreas that produce insulin- without harming most other cells in the body.

12 Feb 2020

Researchers engineer probiotics to safely deliver immunotherapies to tumors

Researchers at Columbia Engineering have engineered probiotics to safely deliver immunotherapies within tumors.

12 Feb 2020

UChicago researchers develop first accurate mouse model of celiac disease

Researchers at the University of Chicago have developed the first truly accurate mouse model of celiac disease. The animals have the same genetic and immune system characteristics as humans who develop celiac after eating gluten. This provides a vital research tool for developing and testing new treatments for the disease.

12 Feb 2020

New therapeutic compounds could fight against brain-eating amoebae

Brain-eating amoebae can cause particularly harmful forms of encephalitis, and more than 95% of people who develop these rare but devastating infections die.

12 Feb 2020

Conservative Indiana adopted needle exchanges but still faces local resistance

Back when Cody Gabbard was shooting heroin, his only significant human contact was with others in the throes of addiction, who only cared to see him when he had drugs.

12 Feb 2020

Recent progress in TB diagnostics and prevention approaches offers hope for future

In September 2018, the National Institute of Allergy and Infectious Diseases, part of the NIH, issued its Strategic Plan for Tuberculosis Research, which outlined research priorities to reduce and ultimately end the burden of tuberculosis.

11 Feb 2020

KAIST researchers identify mechanism that fuels a 'domino effect' in cancer drug resistance

KAIST researchers have identified mechanisms that relay prior acquired resistance to the first-line chemotherapy to the second-line targeted therapy, fueling a "domino effect" in cancer drug resistance.

11 Feb 2020

Accumulated brain protein affects genes in Alzheimer's disease

A new study published in February 2020 in the journal Cell Reports shows how the build-up of specific brain cell proteins are linked to altered gene expression that causes the symptoms of Alzheimer's disease (AD).

11 Feb 2020

Heroin use increasing among American adults

Earlier studies have shown a startling sevenfold increase in illnesses and deaths directly traceable to heroin use in the USA over less than 20 years. Along with this epidemic, HIV and hepatitis infections acquired by injections of drugs have also broken out in large clusters in many places. Yet, the extent of heroin use itself has been neglected. The current study looked at this overlooked area of research.

11 Feb 2020

Macrophages migrate from the blood to attack brain tissue shortly after stroke

Macrophages are part of the innate immune system and essential for brain development and function. Using a novel method, scientists from Jena University Hospital, the University of Bonn and the Memorial Sloan Kettering Cancer Center in New York (USA) succeeded in visualizing macrophages that were formed in the bone marrow.

11 Feb 2020

Telemedicine can help pregnant women struggling with opioids

Sarah, a military veteran living on the coast of South Carolina, knew she had a problem. The opioids prescribed for her pain were becoming a headache of their own.

11 Feb 2020