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Skeleton regulates fertility in males, but not females

Researchers at Columbia University Medical Center have discovered that the skeleton acts as a regulator of fertility in male mice through a hormone released by bone, known as osteocalcin.

17 Feb 2011

Researchers discover substance that reinforces brain's self-healing functions after stroke

The only acute treatment for a stroke currently available is thrombolysis. This uses drugs that dissolve the blood clot responsible for the stroke, but it only reaches around 10 per cent of stroke patients in time to prevent lasting damage. For other patients, there are no other effective drugs that reduce the loss of brain function following a stroke.

17 Feb 2011

Impaired brain insulin action may worsen type 2 diabetes

Researchers from Mount Sinai School of Medicine have discovered a novel function of brain insulin, indicating that impaired brain insulin action may be the cause of the unrestrained lipolysis that initiates and worsens type 2 diabetes in humans. The research is published this month in the journal Cell Metabolism.

17 Feb 2011

Sanofi-aventis, Sunnybrook enter agreement to develop and commercialize vasculotide

Sanofi-aventis and Sunnybrook Health Sciences Centre announced that they have entered into a research agreement and licensing option for vasculotide, an investigational compound to treat chronic wounds. This includes neuropathic diabetic foot ulcers caused by a lack of sensation and neuropathic ulcers that are complicated by peripheral arterial disease, commonly called neuroischemic diabetic foot ulcers.

16 Feb 2011

Study finds GI bleeding rare outside of ICU, regardless of whether or not patients receive medication

Over the last several decades, the prophylactic use of acid-suppressive medications to help prevent gastrointestinal bleeding in hospitalized patients has increased significantly, with some studies estimating that as many as 40 to 70 percent of all medical inpatients are given these drugs at some point during their hospitalization.

15 Feb 2011

Oestrogen reduces risk of breast cancer: Study

A team of researchers at CIC bioGUNE has revealed that oestrogen can reduce the risk of breast cancer. Their work shows that oestrogen is capable of reducing the number of breast cancer stem cells, which may explain the lower aggression of the tumour and, as a consequence, the possibility of a better prognosis.

14 Feb 2011

CX3CL1 signaling chemical can offer better understanding of Parkinson's disease

Targeting the neuroinflammatory causes of Parkinson's disease with a naturally present brain chemical signal could offer a better understanding of the clinical mechanisms of the disease and open a future therapeutic window, reports a team of researchers from the University of South Florida Department Neurosurgery and Brain Repair and the James A. Haley Veterans' Administration Hospital, Tampa.

14 Feb 2011

Tiny gold particles can help doctors detect CTCs in blood of patients with head, neck cancer

Tiny gold particles can help doctors detect tumor cells circulating in the blood of patients with head and neck cancer, researchers at Emory and Georgia Tech have found.

14 Feb 2011

Study: Leptin resistance may help prevent ARDS, ALI development in patients with type II diabetes

Resistance to leptin, a protein that plays a key role in regulating metabolism and appetite, may help prevent the development of acute respiratory distress syndrome and acute lung injury in individuals with type II diabetes, according to a study conducted by researchers in Chicago.

13 Feb 2011

Key advance in development of fast, simple test for detection of cholera

With cholera on the rampage in Haiti and almost 40 other countries, scientists are reporting the development of a key advance that could provide a fast, simple test to detect the toxin that causes the disease. The report appears in ACS' journal Bioconjugate Chemistry. Cholera affects more than 200,000 people annually, mainly in developing countries, and causes about 5,000 deaths. Many involve infants, children, and the elderly.

10 Feb 2011

Targacept initiates TC-6987 Phase 2 study in patients with asthma, Type 2 diabetes

Targacept, Inc., a clinical-stage biopharmaceutical company developing novel NNR Therapeutics™, today announced the initiation of separate Phase 2 clinical studies of its product candidate TC-6987 in disorders characterized by inflammation, one in asthma and one in Type 2 diabetes.

9 Feb 2011

Clinical Data reports $2.0 million revenue for third quarter 2011

Clinical Data, Inc. today announced operational and financial results for the third fiscal quarter ended December 31, 2010. The Company received approval from the U.S. Food and Drug Administration (FDA) of Viibryd™ for the treatment of adults with major depressive disorder (MDD) on January 21, 2011.

9 Feb 2011

Single molecule imaging movies of living cell membranes clarify enigma surrounding receptor molecule behaviors

Unprecedented single molecule imaging movies of living cell membranes, taken by a research team based at Kyoto University and the University of New Mexico, have clarified a decades-old enigma surrounding receptor molecule behaviors. The results, appearing in the latest issue of the Journal of Cell Biology, promise to open the door to new possibilities for drug development.

9 Feb 2011

Single molecule FRET techniques combined with wavelet transforms give new view of AMPA receptor

A digital signal processing technique long used by statisticians to analyze data is helping Houston scientists understand the roots of memory and learning, Alzheimer's and Parkinson's diseases and stroke.

8 Feb 2011

Progenics, Salix enter exclusive worldwide license agreement for RELISTOR

Progenics Pharmaceuticals, Inc. and Salix Pharmaceuticals, Ltd. today announced that they have entered into an exclusive worldwide (except Japan) agreement by which Salix has licensed rights to RELISTOR® (methylnaltrexone bromide).

7 Feb 2011

AMRI fourth quarter total revenue increases 12% to $48.6 million

AMRI today reported financial and operating results for the fourth quarter and full year ended December 31, 2010.

7 Feb 2011

Novel study finds unexpected link between reproductive proteins in humans, invertebrates

A novel study in the scientific journal Molecular Biology and Evolution draws a completely unexpected link between reproductive proteins in humans and proteins involved in fertilization in invertebrates, as well as mating between haploid cells in yeast. Because human and yeast are separated by 1 billion years of evolution, these findings may have important implications for our understanding of the molecular mechanisms underlying sex, and how they originated.

5 Feb 2011

Research provides new clues to understand link between deficits of AGPO-3, depression

The link between deficits of omega-3 poly-unsaturated fatty acids and the onset of depressive disorders is not new in the medical field. However, what has not been known until now is the brain mechanism by which diet can condition mental health to a certain extent.

5 Feb 2011

Scientists unravel mystery about how new tumors in individuals with breast cancer take root

In a discovery that may lead to a new treatment for breast cancer that has spread to the bone, a Princeton University research team has unraveled a mystery about how these tumors take root.

4 Feb 2011

Generic drugs to treat hypertension, heart failure could help NHS save £200 million

Using a generic drug to treat hypertension and heart failure, instead of branded medicines from the same class, could save the UK National Health Service (NHS) at least £200 million in 2011 without any real reduction in clinical benefits.

3 Feb 2011

Receptor News and Research

Skeleton regulates fertility in males, but not females

Researchers discover substance that reinforces brain's self-healing functions after stroke

Impaired brain insulin action may worsen type 2 diabetes

Sanofi-aventis, Sunnybrook enter agreement to develop and commercialize vasculotide

Study finds GI bleeding rare outside of ICU, regardless of whether or not patients receive medication

Oestrogen reduces risk of breast cancer: Study

CX3CL1 signaling chemical can offer better understanding of Parkinson's disease

Tiny gold particles can help doctors detect CTCs in blood of patients with head, neck cancer

Study: Leptin resistance may help prevent ARDS, ALI development in patients with type II diabetes

Key advance in development of fast, simple test for detection of cholera

Targacept initiates TC-6987 Phase 2 study in patients with asthma, Type 2 diabetes

Clinical Data reports $2.0 million revenue for third quarter 2011

Single molecule imaging movies of living cell membranes clarify enigma surrounding receptor molecule behaviors

Single molecule FRET techniques combined with wavelet transforms give new view of AMPA receptor

Progenics, Salix enter exclusive worldwide license agreement for RELISTOR

AMRI fourth quarter total revenue increases 12% to $48.6 million

Novel study finds unexpected link between reproductive proteins in humans, invertebrates

Research provides new clues to understand link between deficits of AGPO-3, depression

Scientists unravel mystery about how new tumors in individuals with breast cancer take root

Generic drugs to treat hypertension, heart failure could help NHS save £200 million

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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