Animal Model News and Research

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Naturally-occurring compound can inhibit early formation of toxins linked to Parkinson's Disease

A naturally-occurring compound has been found to block a molecular process thought to underlie Parkinson's Disease, and to suppress its toxic products, scientists have reported.

17 Jan 2017

Researchers discover underlying cause for formation of granulomas

Granulomas are tissue nodules of immune cells that occur in diseases such as tuberculosis and sarcoidosis and can damage many organs.

16 Jan 2017

Antibiotics targeting brain’s inflammatory response may exacerbate cognitive deficits in children

Traumatic brain injury (TBI) is one of the leading causes of disability and death in infants and children in the United States, with more than half a million affected annually, according to the Centers for Disease Control and Prevention.

11 Jan 2017

Penn State researchers develop novel compound to combat cytomegalovirus

A Retro94-based compound may prevent a common and sometimes fatal virus -- human cytomegalovirus (CMV) -- from reproducing and help to protect immunocompromised patients, such as those with HIV, on chemotherapy, with transplants, and infants from the effects of the disease, according to Penn State College of Medicine researchers.

10 Jan 2017

Researchers discover how deficiency of IgM antibodies can lead to increased risk of arteriosclerosis

Following a blood infection, the first class of antibodies produced by the immune system are IgM antibodies.

9 Jan 2017

Study shows new role of zinc in optic nerve injury

For more than two decades, researchers have tried to regenerate the injured optic nerve using different growth factors and/or agents that overcome natural growth inhibition.

3 Jan 2017

Novel murine model helps shed light on mechanisms involved in reversible infantile liver failure

Reversible infantile liver failure (RILF) is a heritable mitochondrial condition that causes severe liver dysfunction in infancy, but those who survive the acute stage typically recover and have no further problems.

27 Dec 2016

Scientists discover OGDHL and NRD1 genes linked to progressive loss of neurological function

An international team of scientists has discovered that the gene, OGDHL, a key protein required for normal function of the mitochondria -- the energy-producing factory of the cell -- and its chaperone, nardilysin (NRD1) are linked to progressive loss of neurological function in humans.

22 Dec 2016

UT Southwestern researchers find new way to combat multidrug-resistant bacteria in burn injuries

A new way to fight multidrug-resistant bacteria by blinding them rather than killing them proved highly effective in a model of burn injuries, UT Southwestern Medical Center research shows.

21 Dec 2016

Novel approach can regenerate dental pulp-like tissues in animal model

When a tooth is damaged, either by severe decay or trauma, the living tissues that comprise the sensitive inner dental pulp become exposed and vulnerable to harmful bacteria.

19 Dec 2016

Sirt1 plays key role in regenerating glial progenitor cells after hypoxia-induced brain injury in preemies

Developing brains in newborns have a sizable pool of a certain type of immature progenitor cell that can be expanded and induced to replace cells lost to brain injury.

19 Dec 2016

Turning off 'fat-specific protein 27' improves blood sugar levels, reduces body fat in animal model

In a study published in the Journal of Lipid Research, Saint Louis University scientist Angel Baldan, Ph.D., reports that turning off a protein found in liver and adipose tissue significantly improves blood sugar levels, as well as reduces body fat in an animal model.

16 Dec 2016

New drug treatment can override genetic fault that causes choroideremia

Researchers with funding from Fight for Sight have demonstrated that a new drug treatment for cystic fibrosis and Duchenne muscular dystrophy can override a genetic fault that causes choroideremia – a severe blinding disorder.

5 Dec 2016

New self-regulating smart patch releases blood-thinning drugs when necessary

An interdisciplinary team of researchers has developed a smart patch designed to monitor a patient's blood and release blood-thinning drugs as needed to prevent the occurrence of dangerous blood clots - a condition known as thrombosis.

29 Nov 2016

TSRI scientists unravel mystery of ‘food coma’ phenomenon

Anyone who has drifted into a fuzzy-headed stupor after a large holiday meal is familiar with the condition commonly known as a "food coma."

22 Nov 2016

Researchers design smart drug to treat patients with most aggressive brain cancers

Physicians and researchers at Houston Methodist Hospital have designed a new drug to treat patients with the most aggressive, incurable brain cancers.

21 Nov 2016

T cell channel could be potential new target for treating head and neck cancers

Researchers at the University of Cincinnati have discovered that an ion channel, active within T cells (white blood cells), could be targeted to reduce the growth of head and neck cancers.

17 Nov 2016

New mouse model by FDA's scientists provides platform for improving understanding of Zika virus pathology

A new mouse model developed by scientists at the U.S. Food and Drug Administration may help in exploring the potential activity of Zika virus vaccines and therapeutics.

17 Nov 2016

TSRI scientists uncover clues to abnormal brain connections in autism

Autism is an agonizing puzzle, a complex mixture of genetic and environmental factors. One piece of this puzzle that has emerged in recent years is a biochemical cascade called the mTOR pathway that regulates growth in the developing brain.

15 Nov 2016

Repeated binge drinking during adolescence can affect brain functions of future offspring

Repeated binge drinking during adolescence can affect brain functions in future generations, potentially putting offspring at risk for such conditions as depression, anxiety, and metabolic disorders, a Loyola University Chicago Stritch School of Medicine study has found.

15 Nov 2016

Animal Model News and Research

Naturally-occurring compound can inhibit early formation of toxins linked to Parkinson's Disease

Researchers discover underlying cause for formation of granulomas

Antibiotics targeting brain’s inflammatory response may exacerbate cognitive deficits in children

Penn State researchers develop novel compound to combat cytomegalovirus

Researchers discover how deficiency of IgM antibodies can lead to increased risk of arteriosclerosis

Study shows new role of zinc in optic nerve injury

Novel murine model helps shed light on mechanisms involved in reversible infantile liver failure

Scientists discover OGDHL and NRD1 genes linked to progressive loss of neurological function

UT Southwestern researchers find new way to combat multidrug-resistant bacteria in burn injuries

Novel approach can regenerate dental pulp-like tissues in animal model

Sirt1 plays key role in regenerating glial progenitor cells after hypoxia-induced brain injury in preemies

Turning off 'fat-specific protein 27' improves blood sugar levels, reduces body fat in animal model

New drug treatment can override genetic fault that causes choroideremia

New self-regulating smart patch releases blood-thinning drugs when necessary

TSRI scientists unravel mystery of ‘food coma’ phenomenon

Researchers design smart drug to treat patients with most aggressive brain cancers

T cell channel could be potential new target for treating head and neck cancers

New mouse model by FDA's scientists provides platform for improving understanding of Zika virus pathology

TSRI scientists uncover clues to abnormal brain connections in autism

Repeated binge drinking during adolescence can affect brain functions of future offspring

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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