Cell Death News and Research

RSS

Study suggests GILZ protein as a promising anti-hepatic fibrosis drug target

Scientists from Russia and Italy studied a new axis of the pathway that prevents the development of liver fibrosis. The role of GILZ protein in curbing the disease progression was shown in a study using mice models and confirmed by clinical data.

5 May 2021

Disposable face masks release potentially dangerous chemical pollutants

Swansea University scientists have uncovered potentially dangerous chemical pollutants that are released from disposable face masks when submerged in water.

5 May 2021

New enzyme may help curb chronic kidney disease

University of South Australia researchers have identified an enzyme that may help to curb chronic kidney disease, which affects approximately 700 million people worldwide.

4 May 2021

Four-part small-molecule cocktail can prevent cellular stress

Researchers at the National Institutes of Health (NIH) have devised a four-part small-molecule cocktail that can protect stem cells called induced pluripotent stem cells (iPSCs) from stress and maintain normal stem cell structure and function.

4 May 2021

Arresting tumor growth for a variety of cancers through T cell engineering

Through T cell engineering, researchers at Virginia Commonwealth University Massey Cancer Center show that it's possible to arrest tumor growth for a variety of cancers and squash the spread of cancer to other tissues.

30 Apr 2021

Researchers identify important factor in the development of dendritic cells

The human immune system comprises functionally specialized cellular defense mechanisms that protect the body against disease. These include the dendritic cells.

30 Apr 2021

Nanobodies may be the key to blocking tick-borne bacterial infection

Tiny molecules called nanobodies, which can be designed to mimic antibody structures and functions, may be the key to blocking a tick-borne bacterial infection that remains out of reach of almost all antibiotics, new research suggests.

28 Apr 2021

Scientists gain atomic-level insight into behavior of a protein that promotes cancer growth

The neutron reflexometry method has given scientists an atomic-level insight into the behavior of Bcl-2, a protein that promotes cancerous cell growth. The new study was carried out by Umeå chemists in collaboration with the research facilities ESS and ISIS and is published in Nature Communications Biology.

28 Apr 2021

Researchers identify potential therapeutic target to prevent neurodegeneration after a stroke

Researchers with the Peter O'Donnell Jr. Brain Institute at UT Southwestern have identified a new protein implicated in cell death that provides a potential therapeutic target that could prevent or delay the progress of neurodegenerative diseases following a stroke.

27 Apr 2021

Research opens up the possibility of dietary therapy for cancer

A research group at the RIKEN Center for Biosystems Dynamics Research (BDR) has discovered molecular events that determine whether cancer cells live or die. With this knowledge, they found that reduced consumption of a specific protein building block prevents the growth of cells that become cancerous.

27 Apr 2021

Researchers investigate how oxygen radicals protect against cancer

Originally, oxygen radicals - reactive oxygen species, or ROS for short - were considered to be exclusively harmful in the body.

26 Apr 2021

Scientists decode activation mechanism of SHP2 protein that can trigger cancer

There are many different types of cancer, but they all have one thing in common: errors in the signals that control normal cell behavior can cause uncontrolled cell growth and cell division, leading to a tumor.

23 Apr 2021

New potential target for treating metastasized oral malignant melanoma in dogs

Scientists have shown that the biological molecule PD-L1 is a potential target for the treatment of metastasized oral malignant melanoma in dogs.

23 Apr 2021

SARS-CoV-2 infection induces polyfunctional antibodies that can destroy infected cells

Drawing on epidemiological field studies and the FrenchCOVID hospital cohort coordinated by Inserm, teams from the Institut Pasteur, the CNRS and the Vaccine Research Institute (VRI, Inserm/University Paris-Est Créteil) studied the antibodies induced in individuals with asymptomatic or symptomatic SARS-CoV-2 infection.

21 Apr 2021

Study identifies how SARS-CoV-2 enters and infects the brain

A recent preclinical study led by Anja Kipar of the University of Zurich and the University of Liverpool found evidence of the virus infecting and eventually provoking cell death in microglia and immune cells — but not neurons. The viral-induced apoptosis in these brain cells may explain why some long-haulers experience ‘brain fog’ months after recovery.

21 Apr 2021

Scientists identify protein that operates closely with a genetic mutation to spur lung cancer growth

Scientists at VCU Massey Cancer Center have identified a protein that operates in tandem with a specific genetic mutation to spur lung cancer growth and could serve as a therapeutic target to treat the disease.

19 Apr 2021

Study uncovers role for STING in regulating tumor response to DNA-damaging treatments

In a study by Yale Cancer Center, researchers report on the discovery of a new role for STimulator of INterferon Genes or STING.

19 Apr 2021

USP7 inhibitors could increase the anticancer effects of CDK1 compounds in cancer patients

Understanding the components that control cell division is fundamental to understanding how life works and how alterations in this delicate process can cause diseases such as cancer.

19 Apr 2021

Anti-diabetic drug phenformin may prompt stronger cancer-fighting activities

The anti-diabetic drug phenformin may prompt stronger cancer-fighting activities than its sister compound metformin, a finding that could have major implications for current and future clinical trials investigating both agents for their anti-cancer potential, according to researchers at Massachusetts General Hospital (MGH).

15 Apr 2021

A new polymersome-based SARS-CoV-2 nanovaccine elicits robust immunity

As newer vaccines are being developed to combat the ongoing pandemic of coronavirus disease 2019 (COVID-19), targeting the pathogen, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a new preprint research paper posted to the bioRxiv server describes a new subunit nanovaccine that appears to have robust immunogenicity and neutralizing activity.

14 Apr 2021