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How machine learning is accelerating research in structural biology

For Lucas Farnung, there is no question more fascinating than how a single fertilized egg develops into a fully-functioning human.

2 Aug 2024

Using advanced CRISPR to boost efficiency of CAR-T cell therapies

CAR-T cells are highly effective in treating selected blood cancers. However, challenges remain with this new therapy, which was first approved in 2017 in the USA and a year later in Europe for treating acute lymphoblastic leukemia (ALL).

2 Aug 2024

Uncontrolled hypertension: A persistent threat to global health

In the United States and worldwide, cardiovascular disease is the leading avoidable cause of premature death and disability. Primarily heart attacks and stroke, cardiovascular disease accounts for more than 900,000 annual deaths nationally and about 10 million deaths globally.

1 Aug 2024

Aspirin may lower colorectal cancer risk for people with unhealthy lifestyles

Regular aspirin may help lower risk of colorectal cancer in people with greater lifestyle-related risk factors for the disease, according to a study led by researchers at Mass General Brigham.

1 Aug 2024

Fish oil may benefit older adults with genetic Alzheimer's risk

A clinical trial at Oregon Health & Science University suggests that a subset of older adults with a genetic predisposition to Alzheimer's disease may benefit from fish oil supplements.

1 Aug 2024

Study reveals how geographic origins influence tuberculosis infection risk

For some forms of tuberculosis, the chances that an exposed person will get infected depend on whether the individual and the bacteria share a hometown, according to a new study comparing how different strains move through mixed populations in cosmopolitan cities.

1 Aug 2024

Targeting 14 modifiable risk factors from childhood to old age could prevent or delay dementia

Addressing 14 modifiable risk factors, starting in childhood and continuing throughout life, could prevent or delay nearly half of dementia cases, even as people around the world live longer and the number of people with dementia is set to rise dramatically in all countries, according to the third Lancet Commission on dementia prevention, intervention, and care, which is being presented at the Alzheimer's Association International Conference (AAIC 2024).

1 Aug 2024

Study reveals deepening mistrust in healthcare providers post-COVID

A cross-representative survey of adults in the United States showed decreasing levels of trust in physicians and hospitals during the COVID-19 pandemic - and the lower the trust, the less likely an individual was to get vaccinated against SARS-CoV-2 or influenza. The findings come from a survey study of more than 400,000 U.S. adults published in JAMA Network Open by a team co-led by investigators at Massachusetts General Hospital (MGH), a founding member of the Mass General Brigham healthcare system.

1 Aug 2024

Nine months of joint replacement surgery lost due to COVID-19, study reveals

Nearly nine months of joint replacement surgery has been lost - around 160,000 fewer operations - since the start of the COVID-19 pandemic, a new study led by the University of Bristol has found.

31 Jul 2024

New method efficiently converts stem cells to endothelial cells for cardiovascular research

The innermost layer of blood vessels is formed by endothelial cells, which in turn play a role in the development of diseases of the cardiovascular system.

31 Jul 2024

Study reveals common off-label dosing of direct oral anticoagulants

Millions of Americans take anticoagulants, commonly known as blood thinners. These medications work to prevent blood clots that cause heart attack and stroke.

31 Jul 2024

Older adults with diabetes faced elevated risk of depression during the COVID-19 pandemic

A recent study of more than 2,700 older Canadians reported older adults with diabetes faced a heightened risk of depression during the COVID-19 pandemic.

31 Jul 2024

Review highlights the interplay of TGF-β and HIPPO pathways in liver regeneration and disease

The liver's ability to communicate with other organs is crucial for maintaining homeostasis, particularly through signaling pathways.

30 Jul 2024

Hydrogen-rich gas inhalation reduces exercise-induced fatigue and enhances performance

A new study published in the International Journal of Sports Medicine, Inhalation of hydrogen-rich gas before acute exercise alleviates exercise fatigue, has found a possible novel intervention for exercise-induced fatigue.

30 Jul 2024

Epigenetic reprogramming and hypothalamic changes in metabolic syndrome

Metabolic syndrome (MetS) is a multifaceted disorder that impacts approximately 20–25% of the global population.

30 Jul 2024

Duke-NUS expands research capabilities with appointment of Professor Hendrik Luesch from UF

Duke-NUS Medical School today announced the appointment of Professor Hendrik Luesch from the University of Florida (UF) as a joint faculty member.

30 Jul 2024

ACE technology enhances single-cell protein detection with advanced signal amplification

Since the 1950s, researchers have used a famous method invented by Wallace Coulter known as "flow cytometry" to characterize different types of immune cells in research studies and in blood samples from human individuals.

30 Jul 2024

Deciphering miRNA-mediated regulation of liver regeneration: New insights

The liver, a vital organ involved in numerous essential physiological processes such as bile production, plasma protein synthesis, nutrient absorption, detoxification, vitamin storage, macronutrient metabolism, and immune support, has a remarkable regenerative capacity.

29 Jul 2024

Duke-NUS study finds peer influence and incentives boost healthier grocery choices

Amid the rise of chronic diseases, such as heart disease and diabetes, a novel study by Duke-NUS Medical School offers a fresh perspective on encouraging healthier grocery shopping.

29 Jul 2024

New cardiovascular risk calculator could alter treatment for millions

A recently unveiled cardiovascular disease risk calculator that measures a patient's risk for heart attack and stroke is better calibrated and more precise than its previous version, but if current treatment guidelines for cholesterol and blood pressure therapy remain unchanged, the new calculator may have unintended consequences, according to research from Harvard Medical School.

29 Jul 2024

Medical School News and Research

How machine learning is accelerating research in structural biology

Using advanced CRISPR to boost efficiency of CAR-T cell therapies

Uncontrolled hypertension: A persistent threat to global health

Aspirin may lower colorectal cancer risk for people with unhealthy lifestyles

Fish oil may benefit older adults with genetic Alzheimer's risk

Study reveals how geographic origins influence tuberculosis infection risk

Targeting 14 modifiable risk factors from childhood to old age could prevent or delay dementia

Study reveals deepening mistrust in healthcare providers post-COVID

Nine months of joint replacement surgery lost due to COVID-19, study reveals

New method efficiently converts stem cells to endothelial cells for cardiovascular research

Study reveals common off-label dosing of direct oral anticoagulants

Older adults with diabetes faced elevated risk of depression during the COVID-19 pandemic

Review highlights the interplay of TGF-β and HIPPO pathways in liver regeneration and disease

Hydrogen-rich gas inhalation reduces exercise-induced fatigue and enhances performance

Epigenetic reprogramming and hypothalamic changes in metabolic syndrome

Duke-NUS expands research capabilities with appointment of Professor Hendrik Luesch from UF

ACE technology enhances single-cell protein detection with advanced signal amplification

Deciphering miRNA-mediated regulation of liver regeneration: New insights

Duke-NUS study finds peer influence and incentives boost healthier grocery choices

New cardiovascular risk calculator could alter treatment for millions

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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