Microscopy News and Research

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Researchers demonstrate the feasibility of pancreatic beta-cell, target-specific CAR-Treg treatment for T1D

Researchers have successfully treated type 1 diabetes in mice using pancreatic beta-cell, target-specific, chimeric antigen-receptor (CAR) regulatory T cells (Tregs), and demonstrated the feasibility of their approach to treat the human condition according to data being presented Monday, June 13 at ENDO 2022, the Endocrine Society's annual meeting in Atlanta, Ga.

13 Jun 2022

Deciphering the structure of nuclear pore complex piece by piece

Whatever you are doing, whether it is driving a car, going for a jog, or even at your laziest, eating chips and watching TV on the couch, there is an entire suite of molecular machinery inside each of your cells hard at work.

10 Jun 2022

Super-immunity in a camelid extensively immunized with the SARS-CoV-2 receptor-binding domain

A recent study published in Cell Reports reported the development of pan-sarbecovirus nanobodies (psNbs).

10 Jun 2022

Cryo-EM helps scientists to decipher the structure of a key part of RNA degradation machinery

In biology, getting rid of stuff can be just as important as making it. A buildup of cells, proteins, or other molecules that are no longer needed can cause problems, so living things have evolved several ways to clean house.

9 Jun 2022

Advanced microscopy techniques offer detailed insight into inner workings of cells' powerhouses

Using advanced microscopy techniques, researchers at Karolinska Institutet and Stockholm University in Sweden have visualized in unprecedented detail the machinery that the cells' powerhouses, the mitochondria, use to form their proteins.

8 Jun 2022

Discovery of small protein’s structure could lead to new therapies for neurological disorders

Scientists have, for the first time, revealed at the atomic level the structure of a protein that carries one of the body's most important neurotransmitters into neurons.

8 Jun 2022

New diagnostic procedure could help start optimal stroke treatment in a timely manner

A blood clot in the brain that blocks the supply of oxygen can cause an acute stroke. In this case, every minute counts.

8 Jun 2022

Open multiplexing with Cell DIVE offers cancer researchers more choices

Leica has introduced a new generation of its multiplexed imaging solution, Cell DIVE, including software and hardware improvements. The more scalable and efficient multiplexing platform addresses spatial cell biology and function within the tissue microenvironment

From Leica Microsystems GmbH 8 Jun 2022

Cofilin could be a potential target for mitigating atherosclerosis at early stage, finds study

A joint research team at LKS Faculty of Medicine, The University of Hong Kong (HKUMed) and Queen Mary University of London (QMUL) has discovered the molecular mechanisms of how pathological condition-mimicking mechanical stimuli lead to the early progression of atherosclerosis, a leading cause of vascular disease worldwide.

8 Jun 2022

Study demonstrates how some fast-growing bacteria can evade antibiotic treatment

Scientists have demonstrated how some fast-growing bacteria can retreatment with antibiotics, according to a study published today in eLife.

7 Jun 2022

Discovery may lead to new treatments to reduce inflammation in vitiligo disease

A new study, led by researchers from the University of California, Irvine, reveals the unique cell-to-cell communication networks that can perpetuate inflammation and prevent repigmentation in patients with vitiligo disease.

7 Jun 2022

Steady-state DNA motion allows cells to conduct housekeeping tasks under similar nuclear environments

Researchers in Japan have discovered that the local DNA motion inside of human cells remains steady throughout interphase, where the cell grows and replicates its DNA for cell division.

3 Jun 2022

Cellular changes in astrocytes play a crucial role in regulating outcomes for CNS disorders

Investigators at Cedars-Sinai have comprehensively mapped molecular activity in the brain and spinal cord that is responsible for regulating the body's response to central nervous system (CNS) disorders such as Alzheimer's, Huntington's disease and spinal cord injuries.

2 Jun 2022

Ultrasound localization microscopy can image microscopic vessels and measure blood flow in the brain

To image microscopic vessels and measure blood flow in the brain, researchers use a tool called ultrasound localization microscopy. It works by using microscopic bubbles circulated through the bloodstream as a contrast agent to measure the reflection of high-frequency acoustic waves passing through the body.

1 Jun 2022

New findings reveal potential mechanisms for cellular defects in human laminopathies

A Northwestern Medicine study has uncovered distinct roles for major nuclear lamin isoforms in maintaining intracellular interactions and cellular mechanics, according to findings published in the Proceedings of the National Academy of Sciences.

1 Jun 2022

Researchers identify a human monoclonal antibody that could broadly neutralize several variants of SARS-CoV-2, SARS-CoV, and other coronaviruses

Researchers identified 10-40, a human monoclonal antibody with potent neutralizing activity against SARS-CoV, SARS-CoV-2, and related sarbecoviruses.

30 May 2022

Gene linked to severe learning disabilities plays a key role in cells' response to environmental stress

A gene that has been associated with severe learning disabilities in humans has been found to also play a vital role in cells' response to environmental stress, according to a Duke University study appearing May 24 in the journal Cell Reports.

27 May 2022

Understanding transposons provides a new starting point to generate more powerful gene editing tools

CRISPR has ushered in the era of genomic medicine. A line of powerful tools has been developed from the popular CRISPR-Cas9 to cure genetic diseases.

27 May 2022

Researchers report novel interactions between the SARS-CoV-2 S protein and estrogen receptor alpha

Researchers profiled the binding sites of the entire SARS-CoV-2 spike protein sequence.

26 May 2022

Researchers discover mechanisms underlying T-cell receptor's immunosuppressive function

Investigators have discovered the mechanisms underlying a T-cell receptor's immunosuppressive function, according to a study published Nature Immunology, findings that may provide insight into the development of novel precision therapeutics for chronic diseases, including cancer.

25 May 2022

Microscopy News and Research

Researchers demonstrate the feasibility of pancreatic beta-cell, target-specific CAR-Treg treatment for T1D

Deciphering the structure of nuclear pore complex piece by piece

Super-immunity in a camelid extensively immunized with the SARS-CoV-2 receptor-binding domain

Cryo-EM helps scientists to decipher the structure of a key part of RNA degradation machinery

Advanced microscopy techniques offer detailed insight into inner workings of cells' powerhouses

Discovery of small protein’s structure could lead to new therapies for neurological disorders

New diagnostic procedure could help start optimal stroke treatment in a timely manner

Open multiplexing with Cell DIVE offers cancer researchers more choices

Cofilin could be a potential target for mitigating atherosclerosis at early stage, finds study

Study demonstrates how some fast-growing bacteria can evade antibiotic treatment

Discovery may lead to new treatments to reduce inflammation in vitiligo disease

Steady-state DNA motion allows cells to conduct housekeeping tasks under similar nuclear environments

Cellular changes in astrocytes play a crucial role in regulating outcomes for CNS disorders

Ultrasound localization microscopy can image microscopic vessels and measure blood flow in the brain

New findings reveal potential mechanisms for cellular defects in human laminopathies

Researchers identify a human monoclonal antibody that could broadly neutralize several variants of SARS-CoV-2, SARS-CoV, and other coronaviruses

Gene linked to severe learning disabilities plays a key role in cells' response to environmental stress

Understanding transposons provides a new starting point to generate more powerful gene editing tools

Researchers report novel interactions between the SARS-CoV-2 S protein and estrogen receptor alpha

Researchers discover mechanisms underlying T-cell receptor's immunosuppressive function

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