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Mediterranean diet lowers breast cancer risk by 13%, postmenopausal women benefit most

A new meta-analysis of 31 observational studies finds that adherence to the Mediterranean diet is associated with a 13% lower risk of breast cancer in women, particularly among postmenopausal populations. The protective effect was strongest in Asian countries and in case-control study designs.

22 Apr 2025

Interferon regulatory factor 8 identified as key driver of liver fat buildup in NAFLD

Non-alcoholic fatty liver disease (NAFLD) is a hepatic metabolic syndrome resulting from lipid metabolic imbalance. Interferon regulatory factor 8 (IRF8) is well known for its roles in immune cell differentiation and tumor pathogenesis; however, its role in regulating glucose homeostasis and lipid metabolism remains unclear.

22 Apr 2025

Can a plant-based diet help prevent breast cancer?

A case-control study in Iranian women found that higher adherence to a healthy plant-based diet significantly reduces breast cancer risk in postmenopausal women and those with a BMI under 25. In contrast, high intake of unhealthy plant-based foods raised risk in premenopausal women.

22 Apr 2025

Major breakthrough could turn IV drugs into oral treatments for brain cancer and Alzheimer's

A research team led by scientists at The University of Texas Health Science Center at San Antonio (UT Health San Antonio) made a major breakthrough with the potential to turn IV drugs into oral treatments for diseases like brain cancer and Alzheimer's disease.

21 Apr 2025

Diabetes drugs GLP-1RA and SGLT2i lower dementia risk in older adults, study finds

A large population-based study found that GLP-1 receptor agonists (GLP-1RAs) and SGLT2 inhibitors (SGLT2is), two classes of glucose-lowering drugs used in type 2 diabetes, were associated with a significantly reduced risk of Alzheimer’s disease and related dementias (ADRD). These findings suggest potential neuroprotective benefits and highlight drug repurposing as a promising strategy for ADRD prevention.

21 Apr 2025

New therapeutic frontiers in the management of achondroplasia

A recent publication in Genes & Diseases has delivered a compelling synthesis of the latest insights into the cellular mechanisms and therapeutic interventions for achondroplasia, the most common form of genetic dwarfism.

20 Apr 2025

Monell study offers renewed hope for people living with Bardet-Biedl Syndrome

A Monell Chemical Senses Center study published this week in the Journal of Clinical Investigation offers renewed hope for individuals living with Bardet-Biedl Syndrome (BBS), a rare genetic disorder characterized by early-onset obesity, compulsive eating, and cognitive impairments.

18 Apr 2025

Study: Women show greater awareness of obesity drugs than men

New research to be presented at this year's European Congress on Obesity (ECO 2025, Malaga, Spain, 11-14 May) shows that women are much more aware of knowledgeable about the obesity drugs GLP-1/GIP receptor agonists (that include semaglutide and tirzepatide).

17 Apr 2025

Calming the brain's immune cells may curb damaging inflammation in Alzheimer's

New research suggests that calming the brain's immune cells might prevent or lessen the damaging inflammation seen in Alzheimer's disease.

17 Apr 2025

GLP1 agonists linked to depression risk in new genetic study

A groundbreaking study published in the journal Current Neuropharmacology highlights a concerning potential link between Glucagon-like Peptide-1 (GLP1) receptor agonists-widely used in blockbuster drugs like Ozempic-and the risk of depression and suicidal ideation (SI).

17 Apr 2025

Best time for asthma meds? Try 4 pm

Chronotherapy for asthma reveals that afternoon inhaled corticosteroids significantly improve lung function and reduce nighttime symptoms without side effects.

17 Apr 2025

New Canadian guidelines offer comprehensive approach to managing pediatric obesity

Researchers provide evidence-based recommendations to manage pediatric obesity.

17 Apr 2025

Diabetes medications may help shield the brain from cognitive decline

A study led by researchers in the University of Florida College of Pharmacy has found that a pair of popular glucose-lowering medications may have protective effects against the development of Alzheimer's disease and related dementias in patients with Type 2 diabetes.

16 Apr 2025

Comparing single cell RNA methods to improve gastrointestinal cancer research

Research on gastrointestinal diseases, especially cancer, has mainly looked at the epithelial cells, which line the surfaces of organs, are important for various functions, and are believed to be the cells that go awry to cause these diseases.

16 Apr 2025

Promising findings for the treatment of patients with pulmonary arterial hypertension with a high risk of mortality

Pulmonary arterial hypertension (PAH) is a rare and severe lung disease with a life-threatening prognosis. After several positive trials, a recent study has confirmed the efficacy of a biotherapy, sotatercept.

16 Apr 2025

Gut bacteria turn bile acids into allies against cancer

Bacteria naturally present in the human intestine, known as the gut microbiota, can transform cholesterol-derived bile acids into powerful metabolites that strengthen anti-cancer immunity by blocking androgen signaling, according to a preclinical study led by Weill Cornell Medicine investigators.

16 Apr 2025

Nasal protein levels may predict COVID-19 risk

Higher nasal expression of ACE2 and TMPRSS2 proteins can predict future SARS-CoV-2 infection.

16 Apr 2025

Low vitamin D levels damage erectile health via superoxide surge, study finds

Vitamin D deficiency directly causes erectile dysfunction by increasing superoxide and reducing protective SLPI levels, as shown in human tissue and animal models. This breakthrough reveals why low vitamin D may lead to poor sexual health and resistance to standard ED treatments.

15 Apr 2025

Study offers a potential new strategy to improve treatment responses in multiple myeloma patients

Researchers at the VIB-UGent Center for Medical Biotechnology have discovered a promising strategy to improve treatment responses in multiple myeloma patients by blocking a protein that plays a key role in drug resistance.

15 Apr 2025

Researchers analyze the mutational landscape of TMB-high colorectal cancer tumors

Colorectal cancer (CRC), a type of cancer that affects the large intestine and rectum, is one of the leading causes of cancer-related deaths worldwide.

15 Apr 2025

Receptor News and Research

Mediterranean diet lowers breast cancer risk by 13%, postmenopausal women benefit most

Interferon regulatory factor 8 identified as key driver of liver fat buildup in NAFLD

Can a plant-based diet help prevent breast cancer?

Major breakthrough could turn IV drugs into oral treatments for brain cancer and Alzheimer's

Diabetes drugs GLP-1RA and SGLT2i lower dementia risk in older adults, study finds

New therapeutic frontiers in the management of achondroplasia

Monell study offers renewed hope for people living with Bardet-Biedl Syndrome

Study: Women show greater awareness of obesity drugs than men

Calming the brain's immune cells may curb damaging inflammation in Alzheimer's

GLP1 agonists linked to depression risk in new genetic study

Best time for asthma meds? Try 4 pm

New Canadian guidelines offer comprehensive approach to managing pediatric obesity

Diabetes medications may help shield the brain from cognitive decline

Comparing single cell RNA methods to improve gastrointestinal cancer research

Promising findings for the treatment of patients with pulmonary arterial hypertension with a high risk of mortality

Gut bacteria turn bile acids into allies against cancer

Nasal protein levels may predict COVID-19 risk

Low vitamin D levels damage erectile health via superoxide surge, study finds

Study offers a potential new strategy to improve treatment responses in multiple myeloma patients

Researchers analyze the mutational landscape of TMB-high colorectal cancer tumors

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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