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Moderna to develop three new mRNA-based vaccines against HIV, influenza, and the Nipah virus

Morderna has announced plans to develop a range of new mRNA-based vaccines against other viruses, including the influenza virus, human immunodeficiency virus (HIV), and the Nipah virus.

13 Jan 2021

Researchers map genetic changes that may have facilitated SARS-CoV-2’s jump from bats to humans

Researchers from the University of Cambridge and the Pirbright Institute in the UK have identified key genetic changes in SARS-CoV-2 that may be responsible for the virus’s jump from bats to humans. The team also determined which animals contain cellular receptors that allow the virus to enter cells more effectively, zoning in on potential animals that acted as an intermediary host in facilitating SARS-CoV-2’s zoonosis.

13 Jan 2021

New N501 SARS-CoV-2 mutation may have been circulating in Italy since August 2020

A recent study shows that mutated SARS-CoV-2 strains with a substitution at position 501 might have circulated unnoticed even before the end of September 2020, when the rapid emergence of B.1.1.7 lineage (carrying the N501Y mutation) was initially reported.

13 Jan 2021

New findings could help better understand the mechanisms underlying severe malaria

The levels of small molecules called microRNAs (miRNAs) circulating in blood could help identify early on children with life-threatening forms of malaria, according to a study led by the Barcelona Institute for Global Health, an institution supported by "la Caixa" Foundation, in collaboration with the Manhiça Health Research Center (CISM) in Mozambique.

13 Jan 2021

Study shows faster uptake of chemicals in people with a genetically weakened skin barrier

The ability of our skin to protect us from chemicals is something we inherit. Some people are less well-protected which could imply an increased risk of being afflicted by skin disease or cancer.

13 Jan 2021

Researchers identify link between ALS and accumulation of DNA-RNA hybrids in the genome

Researchers from the University of Seville and the University of Pavia have identified a link between Amyotrophic Lateral Sclerosis (ALS) and the accumulation of DNA-RNA hybrids in the genome.

13 Jan 2021

New UK-derived SARS-CoV-2 variant does not affect neutralizing antibodies efficiency, study says

A team of scientists conducted structural analysis of a newly emerged UK variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). They present evidence that suggests that while the new variant has increased infectivity it is not resistant to neutralizing antibodies.

13 Jan 2021

Could fenofibrate be an effective antiviral against SARS-CoV-2?

The resurgence of COVID-19 pandemic, caused by the SARS-CoV-2, has led to renewed efforts to find effective antivirals, both newly developed or repurposed drugs. A study reports the efficacy of the cholesterol-reducing drug fenofibrate in reducing infection rates of SARS-CoV-2 in cultured cells.

13 Jan 2021

Researchers investigate protein phosphatase to identify new treatments for cancer, other diseases

The abundant presence of an enzyme known as low molecular weight protein tyrosine phosphatase (LMWPTP) in tumor cells has long been considered an indicator of cancer aggressiveness and metastatic potential.

13 Jan 2021

New technology could protect against different coronavirus variants

The SARS-CoV-2 virus that is causing the COVID-19 pandemic is just one of many different viruses in the coronavirus family.

13 Jan 2021

New results help understand biological phenomena mediated by cell membrane integrin receptors

Researchers at Tampere University, Finland, have published new results in collaboration with an international research network that help to understand the biological phenomena mediated by cell membrane integrin receptors and contribute to the development of methods for the treatment of cancer.

13 Jan 2021

New technology helps study muscle biology more clearly

Exercising regularly is one of the best defenses against metabolic diseases, such as obesity and diabetes - but why? It's a question that scientists are still struggling to answer. While exercising changes the molecular behavior of muscles, it's not well understood how these molecular changes improve metabolic health.

13 Jan 2021

Researchers develop novel antibody fragments against SARS coronavirus-2

An international research team led by the University of Bonn (Germany) has identified and further developed novel antibody fragments against the SARS coronavirus-2. These "nanobodies" are much smaller than the classic antibodies used to treat US President Donald Trump, for example.

13 Jan 2021

New publication describes DiosCURE’s multivalent single-chain antibodies to inactivate SARS-CoV-2

DiosCURE SE announced a publication in Science describing its core technology of multivalent single-chain antibodies with a unique molecular mode-of-action to inactivate SARS-CoV-2 virions. An international team led by scientists at the University of Bonn developed and characterized the lead candidates, which are exclusively licensed by DiosCURE.

13 Jan 2021

Biologists reveal unusual structure of coronavirus protein linked to immune evasion

A team of HIV researchers, cellular biologists, and biophysicists who banded together to support COVID-19 science determined the atomic structure of a coronavirus protein thought to help the pathogen evade and dampen response from human immune cells.

13 Jan 2021

Study shows how neurons can become a target of SARS-CoV-2 infection

Using both mouse and human brain tissue, researchers at Yale School of Medicine have discovered that SARS-CoV-2 can directly infect the central nervous system and have begun to unravel some of the virus's effects on brain cells.

13 Jan 2021

New clinical practice guidelines on diagnosis, management of von Willebrand Disease

The American Society of Hematology (ASH), the International Society on Thrombosis and Haemostasis (ISTH), National Hemophilia Foundation (NHF), and World Federation of Hemophilia (WFH) have developed joint clinical practice guidelines on the diagnosis and management of von Willebrand Disease (VWD), the world's most common inherited bleeding disorder. The guidelines were published today in Blood Advances.

13 Jan 2021

Antibody-Fc-mediated innate immunity shapes COVID-19 severity

A short paper that appeared recently on the preprint bioRxiv server pointed to a link between specific characteristics of anti-SARS-CoV-2 antibodies associated with the severity of COVID-19.

12 Jan 2021

Intranasal vaccination effectively reduces viral shedding of SARS-CoV-2 in monkeys

A new preprint that appeared on the bioRxiv server reports that intranasal vaccination with the D614G variant of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in rhesus monkeys reduces viral shedding. This is an experiment in non-human primates (NHP), and its extrapolation to humans is unclear as yet.

12 Jan 2021

Structure of SARS-CoV-2 cytoplasmic tail uncovered

The virus's cytosolic tail also interacts with the host cell to promote its entry into the endoplasmic reticulum (ER). A new study appearing on the bioRxiv preprint server elucidates the conformation of this region of the virus, which will help understand how its form is related to its function in viral entry.

12 Jan 2021

Protein C News and Research

Moderna to develop three new mRNA-based vaccines against HIV, influenza, and the Nipah virus

Researchers map genetic changes that may have facilitated SARS-CoV-2’s jump from bats to humans

New N501 SARS-CoV-2 mutation may have been circulating in Italy since August 2020

New findings could help better understand the mechanisms underlying severe malaria

Study shows faster uptake of chemicals in people with a genetically weakened skin barrier

Researchers identify link between ALS and accumulation of DNA-RNA hybrids in the genome

New UK-derived SARS-CoV-2 variant does not affect neutralizing antibodies efficiency, study says

Could fenofibrate be an effective antiviral against SARS-CoV-2?

Researchers investigate protein phosphatase to identify new treatments for cancer, other diseases

New technology could protect against different coronavirus variants

New results help understand biological phenomena mediated by cell membrane integrin receptors

New technology helps study muscle biology more clearly

Researchers develop novel antibody fragments against SARS coronavirus-2

New publication describes DiosCURE’s multivalent single-chain antibodies to inactivate SARS-CoV-2

Biologists reveal unusual structure of coronavirus protein linked to immune evasion

Study shows how neurons can become a target of SARS-CoV-2 infection

New clinical practice guidelines on diagnosis, management of von Willebrand Disease

Antibody-Fc-mediated innate immunity shapes COVID-19 severity

Intranasal vaccination effectively reduces viral shedding of SARS-CoV-2 in monkeys

Structure of SARS-CoV-2 cytoplasmic tail uncovered

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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