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Study provides insight into link between cancer driver gene and alternative splicing changes

A multi-institutional group of researchers led by Children's Hospital of Philadelphia has linked a strong cancer driver gene to changes in proteins that regulate alternative splicing.

17 Feb 2020

Research suggests new approach to block tau pathology in FTLD, Alzheimer's

The protein β-arrestin-2 increases the accumulation of neurotoxic tau tangles, a cause several forms of dementia, by interfering with removal of excess tau from the brain, a new study by the University of South Florida Health Morsani College of Medicine found.

17 Feb 2020

Targeting regulatory T cells could boost the effects of cancer immunotherapy

A Ludwig Cancer Research study has identified a mechanism by which regulatory T cells, which suppress immune responses, adapt their metabolism to thrive in the harsh microenvironment of the tumor.

17 Feb 2020

Intratumoral heterogeneity linked to chemotherapy resistance in small-cell lung cancer

Small cell lung cancer accounts for 14% of all lung cancers and is often rapidly resistant to chemotherapy, resulting in poor clinical outcomes.

17 Feb 2020

Coping with adult nightmares

Bad dreams or nightmares affect not only children but adults, too. Haunting nightmares can affect a person’s sleep quality and duration, but is it possible to turn off a nightmare while it is happening?

17 Feb 2020

Individual clinical judgments needed for prescribing aspirin in primary prevention

The most recent guidelines for primary prevention recommend aspirin use for individuals ages 40 to 70 years who are at higher risk of a first cardiovascular event, but not for those over 70. Yet, people over 70 are at increasingly higher risks of cardiovascular events than those under 70.

17 Feb 2020

Combination therapy for pediatric low-grade gliomas shows promise in mice

In experiments with human cells and mice, researchers at the Johns Hopkins Kimmel Cancer Center report evidence that combining the experimental cancer medication TAK228 (also called sapanisertib) with an existing anti-cancer drug called trametinib may be more effective than either drug alone in decreasing the growth of pediatric low-grade gliomas.

17 Feb 2020

UCLA researcher designs ways for immune cells to 'outsmart' solid tumors

Yvonne Chen engineers immune cells to target their most evasive enemy: cancer. New cancer immunotherapies generate immune cells that are effective killers of blood cancers, but they have a hard time with solid tumors.

16 Feb 2020

Researchers develop new way to monitor radiation doses for cancer patients

More than half of all cancer patients undergo radiation therapy and the dose is critical. Too much and the surrounding tissue gets damaged, too little and the cancer cells survive.

16 Feb 2020

Drinking cocoa could relieve peripheral arterial disease

Someday, according to a new study, doctors might prescribe chocolate or cocoa to help patients with peripheral arterial disease to walk easier. The study published in February 2020 in the journal Circulation Research of the American Heart Association (AHA) reports a significant improvement in walking distance in patients following regular cocoa consumption.

16 Feb 2020

Scientists map molecular steps in the development of endometrial cancer

A new study reveals the molecular steps that bring about endometrial cancer, commonly known as uterine cancer, which is the sixth most common cancer in women across the globe.

16 Feb 2020

New ligament repair procedure shows promise to relieve wrist pain, restore function

Over the past three decades, hand surgeon Scott Wolfe has been conducting research to find a better way to repair a common wrist injury that results in pain, disability and progressive arthritis.

16 Feb 2020

New biological tool can detect and debug faulty genetic circuits

Every cell in our body has a computer-like control system that sends biological signals through thousands of circuits to monitor the cell's needs and regulate its responses.

16 Feb 2020

TSF awards new grants to support research and education programs in cardiothoracic surgery

The Thoracic Surgery Foundation- the charitable arm of The Society of Thoracic Surgeons- has awarded 29 new grants totaling $1,047,500 in support of research and education programs in cardiothoracic surgery.

16 Feb 2020

Advancing a protein drug in lettuce leaves to treat pulmonary arterial hypertension

In pulmonary arterial hypertension, high blood pressure in the lungs' arteries causes the heart to work extra hard to pump blood to the lungs and around the rest of the body.

16 Feb 2020

Vitamin E can safely treat fatty liver disease in patients with HIV

A type of fatty liver disease that commonly affects patients with HIV can be safely treated with vitamin E, a McGill-led study has found.

16 Feb 2020

New set of recommendations for managing liver failure in the ICU

For critical care specialists, hepatic failure poses complex challenges unlike those of other critical illnesses.

16 Feb 2020

Scientists pinpoint protein that plays key role in lung cancer and melanoma progression

Scientists from Far Eastern Federal University, University of Geneva (Switzerland), Minjiang University, and Fuzhou University (China) pointed out WDR74 protein playing an important role in lung cancer and melanoma primary tumors/metastases progression.

16 Feb 2020

Scientists create world’s first model of pituitary disease using human iPS cells

Researchers at Kobe University's Graduate School of Medicine have developed the world's first congenital pituitary hypoplasia model using patient-derived iPS cells.

14 Feb 2020

Thoracic radiation therapy can have negative impact on cancer patients' quality of life

Radiation doses to the heart that occur during radiation therapy treatments for lung cancer, breast cancer and lymphoma can increase fatigue, cause difficulty breathing and lower capacity for physical activity in patients with cancer, according to research presented at the American College of Cardiology's Advancing the Cardiovascular Care of the Oncology Patient course.

14 Feb 2020

Therapy News and Research

Study provides insight into link between cancer driver gene and alternative splicing changes

Research suggests new approach to block tau pathology in FTLD, Alzheimer's

Targeting regulatory T cells could boost the effects of cancer immunotherapy

Intratumoral heterogeneity linked to chemotherapy resistance in small-cell lung cancer

Coping with adult nightmares

Individual clinical judgments needed for prescribing aspirin in primary prevention

Combination therapy for pediatric low-grade gliomas shows promise in mice

UCLA researcher designs ways for immune cells to 'outsmart' solid tumors

Researchers develop new way to monitor radiation doses for cancer patients

Drinking cocoa could relieve peripheral arterial disease

Scientists map molecular steps in the development of endometrial cancer

New ligament repair procedure shows promise to relieve wrist pain, restore function

New biological tool can detect and debug faulty genetic circuits

TSF awards new grants to support research and education programs in cardiothoracic surgery

Advancing a protein drug in lettuce leaves to treat pulmonary arterial hypertension

Vitamin E can safely treat fatty liver disease in patients with HIV

New set of recommendations for managing liver failure in the ICU

Scientists pinpoint protein that plays key role in lung cancer and melanoma progression

Scientists create world’s first model of pituitary disease using human iPS cells

Thoracic radiation therapy can have negative impact on cancer patients' quality of life

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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