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Disease modifying activity of 2ME2 demonstrated in preclinical rheumatoid arthritis studies

EntreMed a clinical-stage pharmaceutical company developing therapeutics primarily for the treatment of cancer and inflammatory diseases, has announced the presentation of positive preclinical results for its lead compound, 2-methoxyestradiol (2ME2), in models of rheumatoid arthritis.

24 Aug 2005

Scientists convert human embryonic stem cells into lung cells

According to research to be published in the journal Tissue Engineering, the team from Imperial College London, took human embryonic stem cells and 'directed' them to convert into the type of cells needed for gas exchange in the lung, known as mature small airway epithelium.

24 Aug 2005

New technique for creating human embryonic stem cells

Researchers have developed a new technique for creating human embryonic stem cells by fusing adult somatic cells with embryonic stem cells. The fusion causes the adult cells to undergo genetic reprogramming, which results in cells that have the developmental characteristics of human embryonic stem cells.

22 Aug 2005

Malfunctioning bone marrow cells cause neuropathy in many people with diabetes

Malfunctioning bone marrow cells that produce insulin appear to cause a dangerous nerve condition called neuropathy that disables many people with diabetes, said a research team led by Baylor College of Medicine (BCM) in Houston.

22 Aug 2005

First proof of how the rare disorder Fanconi anemia causes chromosomal instability

The scientists found a gene mutation not previously known to be related to Fanconi anemia, and they say that BRIP1 is the first gene associated with the disease whose protein has a known function.

22 Aug 2005

Discovery of new gene FANCM sheds light on repair of damaged DNA

National Institute on Aging (NIA) researchers have discovered a new gene, FANCM, which sheds light on an important pathway involved in the repair of damaged DNA.

22 Aug 2005

Women who take oral contraceptives can counteract bone loss by increasing calcium in their daily diet

Women who take oral contraceptives can counteract bone loss by making sure they have enough calcium in their daily diet, especially early in life, according to Purdue University research.

17 Aug 2005

Breakthrough in human stem cell research

A breakthrough in human stem cell research, producing embryonic-like cells from umbilical cord blood may substantially speed up the development of treatments for life-threatening illnesses, injuries and disabilities.

16 Aug 2005

Adalimumab and methotrexate is about five times more effective than methotrexate alone for rheumatoid arthritis

For people with long-standing rheumatoid arthritis, combined treatment with the new "biologic" drug adalimumab and methotrexate is about five times more effective than methotrexate alone, according to a new systematic review of studies.

15 Aug 2005

$Diabetics who require surgery for ankle fractures fare worse than non-diabetics after surgery$

Diabetics who require surgery for ankle fractures fare worse than non-diabetics after surgery

In the largest analysis of its kind, Duke University Medical Center researchers have found that patients with diabetes who require surgery for ankle fractures have significantly higher rates of complications and higher hospital costs compared to non-diabetic patients.

15 Aug 2005

Pre-mRNA that codes for inflammatory protein identified

In a discovery that upends a longstanding tenet of human biology, University of Utah School of Medicine researchers have shown that a key process in gene regulation can occur in human platelets, unique cells that are unusual because they don't have a nucleus (anucleate).

11 Aug 2005

Rochester Institute of Technology showcases landmark medical imaging project

Using revolutionary medical imaging technology, researchers at Rochester Institute of Technology are providing a better understanding of the human body and its many secrets.

11 Aug 2005

Researchers find drug targets for treating metabolic syndrome

Ongoing studies by researchers at UT Southwestern Medical Center and other institutions have uncovered the biochemical basis of many of the factors contributing to what is known as the metabolic syndrome, suggesting potential new drug targets for treating the condition.

11 Aug 2005

Australian scientists rejuvenate the immune systems of mice and humans using a common hormone

The scientists, led by Associate Professor Richard Boyd and Dr Jayne Sutherland from the Monash Immunology and Stem Cell Laboratories, have revitalised the thymus which produces the T cells required to fight infection but which shuts down from early adulthood.

11 Aug 2005

Taking parathyroid hormone followed by a year on alendronate shows strong osteoporosis benefit

Postmenopausal women who took a bone-building drug for one year followed by a year on a standard drug that fights bone loss experienced greater increases in bone density than has been reported from any other drug regimen, an NIH-sponsored study has found. Bone density is the standard predictor of fracture risk associated with osteoporosis.

11 Aug 2005

$Experts predict that bone fractures will become a bigger and more costly problem$

Experts predict that bone fractures will become a bigger and more costly problem

With an aging population, and with people living longer, experts say bone fractures will become a bigger and more costly problem unless more is done to prevent them.

9 Aug 2005

Switching treatment to the drug anastrozole after two years of tamoxifen is beneficial for women with early breast cancer

Switching treatment to the drug anastrozole after two years of tamoxifen can improve eventfree survival for postmenopausal women with early breast cancer, concludes a study in this week’s issue of The Lancet.

4 Aug 2005

Natural killer cells help understand responses to bone marrow transplants

Scientists have discovered that a group of important immune system cells has a surprising resemblance to cinematic British superspy James Bond: the cells receive a "license" that allows them to unleash their most potent attacks on enemies.

4 Aug 2005

Bone marrow-derived cells fail to meet high expectations says Bonn study

Adult stem cells taken from bone marrow are the "shooting stars" of their field. Many research scientists have been speculating that the cells might be able to pass through the blood into diseased organs and replace defective tissue. Such cells are seen as the potential key to the treatment of certain muscle diseases.

3 Aug 2005

Study addresses critical GVHD complication - limitations of bone marrow transplants

Together with 16 other institutions in the United States, University of Minnesota researchers led the largest study to date in patients with leukemia and related disorders undergoing bone marrow transplantation from unrelated donors.

2 Aug 2005

Bone News and Research

Disease modifying activity of 2ME2 demonstrated in preclinical rheumatoid arthritis studies

Scientists convert human embryonic stem cells into lung cells

New technique for creating human embryonic stem cells

Malfunctioning bone marrow cells cause neuropathy in many people with diabetes

First proof of how the rare disorder Fanconi anemia causes chromosomal instability

Discovery of new gene FANCM sheds light on repair of damaged DNA

Women who take oral contraceptives can counteract bone loss by increasing calcium in their daily diet

Breakthrough in human stem cell research

Adalimumab and methotrexate is about five times more effective than methotrexate alone for rheumatoid arthritis

Diabetics who require surgery for ankle fractures fare worse than non-diabetics after surgery

Pre-mRNA that codes for inflammatory protein identified

Rochester Institute of Technology showcases landmark medical imaging project

Researchers find drug targets for treating metabolic syndrome

Australian scientists rejuvenate the immune systems of mice and humans using a common hormone

Taking parathyroid hormone followed by a year on alendronate shows strong osteoporosis benefit

Experts predict that bone fractures will become a bigger and more costly problem

Switching treatment to the drug anastrozole after two years of tamoxifen is beneficial for women with early breast cancer

Natural killer cells help understand responses to bone marrow transplants

Bone marrow-derived cells fail to meet high expectations says Bonn study

Study addresses critical GVHD complication - limitations of bone marrow transplants

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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