Mutation News and Research

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Swine flu numbers still rising, but China insists disease is under control

Although the number of people now infected by the deadly swine flu in China has risen to 18, health authorities are playing down the impact, and are still insisting that they have the outbreak under control.

1 Aug 2005

Key step in the entry of anthrax toxin into human cells

The work, which grew out of an ongoing effort to produce a better anthrax therapeutic, shows that the protective antigen component of the bacterial toxin plays an active role in transferring the other two components of the toxin through the cell membrane.

28 Jul 2005

Twenty seven dead and 131 now sick with swine flu in China

According to Chinese state media, the number of people infected by what authorities believe is a pig-borne bacterial disease in the southwest has jumped to 131.

28 Jul 2005

Participants in the gene therapy market discover new ways to improve clinical efficiency and generate revenue

The gene therapy market has had limited success with products during the clinical development process. Due to toxicological complications and poor therapy efficacy, healthcare authorities have suspended several gene therapy trials worldwide.

28 Jul 2005

Researchers make headway in mystery of migraines

The research, published in the new issue of the Proceedings of National Academy of Sciences (PNAS), reveals how gene mutations known to cause a form of inherited migraine target a cellular process involved in brain cell communication.

27 Jul 2005

Exposure to second-hand smoke during pregnancy can be just as detrimental to a developing fetus as primary exposure through maternal smoking

In a study published in the online journal BMC Pediatrics, Stephen G. Grant, Ph.D., associate professor of environmental and occupational health, reports that both active maternal smoking and secondary maternal exposure result in similarly increased rates of genetic mutation that are basically indistinguishable.

26 Jul 2005

Bird flu could spread to Europe on wings of Asian wild geese

Migratory wild birds from China, which were found to have contracted bird flu from poultry, could potentially spread the disease to Europe, as well as Australia, Chinese scientists report.

26 Jul 2005

Analysis of the Phase I/II clinical trial of HIV drug candidate PA-457

V.I. Technologies (Vitex) and collaborators at the University at Buffalo's School of Pharmacy and Pharmaceutical Sciences, Buffalo, NY, today presented a detailed analysis of the Phase I/II clinical trial of its HIV drug candidate PA-457 at the 3rd International AIDS Society (IAS) Conference on HIV Pathogenesis and Treatment in Rio de Janeiro, Brazil.

26 Jul 2005

First large-scale effort to sequence the flu genome

Multiple strains of the flu virus, circulating in a population at the same time, can reshuffle their genes and create a new virus, one capable of infecting many more people, according to a new study in the open-access journal PLoS Biology.

26 Jul 2005

Scientists have identified the first genetic mutations that cause the aorta to widen, tear and rupture

Finding biological markers that flag aneurysm, a bulging of the aorta that leads to dissection, a lengthwise separation of tissues in the artery wall, is critically important for early diagnosis.

25 Jul 2005

Multiple rare mutations within a single gene may increase risk for autism

While debate still rages over the 'cause' of autism, mounting evidence suggests that genetic factors play a major role in the disease.

25 Jul 2005

Variation in HIV's ability to disable host defenses contributes to rapid evolution

One of the reasons HIV is so difficult to contain and treat is its rapid evolution. Understanding how host defenses and viral countermeasures contribute to that evolution is vital.

25 Jul 2005

Discovery of a receptor that appears to function as one "lock" that HSV opens to allow it to enter human cells

It's one of the most common viruses in America, and one that causes the most guilt and shame. It can get inside almost any kind of human cell, reproduce in vast numbers, and linger for years in the body, causing everything from recurrent genital blisters to sores around the mouth. Its complications can kill, and it may increase susceptibility to many nerve and brain disorders.

24 Jul 2005

Definitive proof that Ab42 is the culprit molecule that underlies the pathology of Alzheimer's disease

One puzzle in Alzheimer's disease (AD) research is why mice engineered to have the abnormal protein underlying the disease in humans show little pathology of the disease. Specifically, such mice are genetically altered to overproduce mutant human amyloid precursor protein (APP).

21 Jul 2005

New research suggests that accumulation of amyloid-beta peptides in cerebral blood vessels causes vascular damage in Alzheimer's disease

New research suggests that accumulation of amyloid-â peptides in cerebral blood vessels, as opposed to the brain itself, may be a more important pathological mediator of Alzheimer's disease. Two independent yet related articles describe such findings in the August issue of The American Journal of Pathology.

21 Jul 2005

Fertility drugs may be ineffective for women who lack a gene called the estrogen receptor beta

"What we found is that the beta estrogen receptor plays a role in moving the egg outside the ovary so it can be fertilized," said Kenneth Korach, Ph.D., Laboratory Chief at the National Institute of Environmental Health Sciences (NIEHS) where the research was conducted. "We never knew before what function this receptor played in reproduction."

20 Jul 2005

University of Florida researcher finds way to explore role of microRNAs in specific tissue

University of Florida researchers have learned how to selectively shut down a flyweight-sized genetic molecule that packs a heavyweight punch, a discovery that may help doctors better understand cancer, birth defects and other health problems.

20 Jul 2005

SIRT1 gene suppresses longevity

Researchers have determined that a gene present in mouse cells limits the number of times that a cell can divide. The gene is involved in a process, called senescence, which is thought to ensure that aging cells do not pass on harmful mutations.

20 Jul 2005

Insulin keeps fat in the liver under control

Insulin, a hormone long recognized as a generator of fat, also keeps fat in the liver under control, according to a new study in the July issue of Cell Metabolism.

19 Jul 2005

Variant of a common protein plays a primary role in Type 2 diabetes and obesity

Scientists in France and the United States report that a variant of a common protein plays a primary role in Type 2 diabetes and obesity, key features of the "insulin resistance syndrome" that affects more than 50 million people in this country and a similar number in Europe.

19 Jul 2005

Mutation News and Research

Swine flu numbers still rising, but China insists disease is under control

Key step in the entry of anthrax toxin into human cells

Twenty seven dead and 131 now sick with swine flu in China

Participants in the gene therapy market discover new ways to improve clinical efficiency and generate revenue

Researchers make headway in mystery of migraines

Exposure to second-hand smoke during pregnancy can be just as detrimental to a developing fetus as primary exposure through maternal smoking

Bird flu could spread to Europe on wings of Asian wild geese

Analysis of the Phase I/II clinical trial of HIV drug candidate PA-457

First large-scale effort to sequence the flu genome

Scientists have identified the first genetic mutations that cause the aorta to widen, tear and rupture

Multiple rare mutations within a single gene may increase risk for autism

Variation in HIV's ability to disable host defenses contributes to rapid evolution

Discovery of a receptor that appears to function as one "lock" that HSV opens to allow it to enter human cells

Definitive proof that Ab42 is the culprit molecule that underlies the pathology of Alzheimer's disease

New research suggests that accumulation of amyloid-beta peptides in cerebral blood vessels causes vascular damage in Alzheimer's disease

Fertility drugs may be ineffective for women who lack a gene called the estrogen receptor beta

University of Florida researcher finds way to explore role of microRNAs in specific tissue

SIRT1 gene suppresses longevity

Insulin keeps fat in the liver under control

Variant of a common protein plays a primary role in Type 2 diabetes and obesity

Event guide: 4th Extra-Hepatic Lipid-Based Nanoparticles Delivery Summit eBook

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

Bringing real-time analytics to downstream bioprocess monitoring

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