CD4 News and Research

RSS

HIV status does not affect Tecovirimat treatment outcomes for Mpox virus infection

A retrospective cohort study comparing the clinical presentation and treatment outcomes of people with HIV and those without HIV who were treated with tecovirimat for confirmed mpox virus infection. The study found that HIV status did not seem to affect treatment outcomes.

4 May 2023

Study identifies immune signature to predict severe COVID-19 in cardiovascular patients

Research investigates whether the severity of SARS-CoV-2 infection can be predicted by analyzing the immunophenotype in the blood of cardiovascular disease (CVD) patients.

1 May 2023

Research identifies Th1 memory CD4+ T cells as key to protect against emerging poxvirus skin infections

Researchers demonstrate that T helper 1 effector memory cluster of differentiation 4 T cells provide immunity against poxviruses

27 Apr 2023

Possible risk factors for brain aneurysm development in adults living with HIV

With advances in antiretroviral therapy (ART), outcomes for adults living with human immunodeficiency virus (ALWH) have largely improved, drastically decreasing the risk of death from opportunistic infections.

26 Apr 2023

T cell-mediated recognition of conserved bacterial epitope generates broad immunity

Typically T cells of the immune system respond to a specific feature (antigen) of a microbe, thereby generating protective immunity.

25 Apr 2023

Protective mucosal and systemic immunity provided by a single-dose novel live-attenuated intranasal SARS-CoV-2 vaccine candidate

Researchers explored the protective systemic and mucosal immunity provided by a single dose of a live-attenuated SARS-CoV-2 vaccine candidate.

20 Apr 2023

Unlocking the potential of RNA lipid nanoparticles to revolutionize cancer treatment

This paper discusses the use of RNA lipid nanoparticles for cancer immunotherapy, which has shown promising results in clinical use. However, only a small percentage of patients respond to existing immunotherapies, and the paper explores opportunities for improvement.

18 Apr 2023

Understanding human mycobiome commensalism and pathogenesis

Researchers explored commensalism and pathogenesis relationships in the human mycobiome.

18 Apr 2023

Tissue-resident memory cells are key to immunity to Salmonella in mice

Salmonella infections cause about a million deaths a year worldwide, and there is an urgent need for better vaccines for both typhoid fever and non-typhoidal Salmonella disease.

18 Apr 2023

Vaccine component BNT162b4 enhances T-cell immunity against SARS-CoV-2 variants for reduced COVID-19 disease severity

Researchers designed a novel messenger ribonucleic acid (mRNA) vaccine component designated BNT162b4.

17 Apr 2023

Pregnant women show unique immune response to COVID-19

Researchers compare the adaptive, innate, and humoral immune responses between pregnant and non-pregnant women with COVID-19.

16 Apr 2023

Daily statin medication could improve cardiovascular outcomes in people with HIV

A National Institutes of Health clinical trial was stopped early because a daily statin medication was found to reduce the increased risk of cardiovascular disease among people living with HIV in the first large-scale clinical study to test a primary cardiovascular prevention strategy in this population.

11 Apr 2023

COVID mRNA vaccines fall short in eliciting lung resident memory T cells compared to natural infection

Pieren, D. K. J., Kuguel, S. G., Rosado, J., Robles, A. G., Rey-Cano, J., Mancebo, C., Esperalba, J., Falcó, V., Buzón, M. J., & Genescà, M. (2023). Limited induction of polyfunctional lung-resident memory T cells against SARS-CoV-2 by mRNA vaccination compared to infection. Nature Communications, 14(1). https://doi.org/10.1038/s41467-023-37559-w, https://www.nature.com/articles/s41467-023-37559-w

10 Apr 2023

Study assesses the cellular and molecular immunopathology of post-COVID lung disease

Researchers assessed the cellular and molecular level immunopathology of PCLD.

4 Apr 2023

Researcher hypothesizes that overnutrition could lead to loss of self-tolerance by impinging on immune regulation

Researchers explored the correlation between autoimmunity and obesity.

3 Apr 2023

New therapeutic approach to eliminate aging cells by boosting anti-viral immune response

Aging, or senescent cells, which stop dividing but don't die, can accumulate in the body over the years and fuel chronic inflammation that contributes to conditions such as cancer and degenerative disorders.

30 Mar 2023

The breadth of immune responses following COVID-19 vaccination in hematology patients with diseases and treatments impacting B cell immunity

A study published in Cell Reports Medicine describes that COVID-19 vaccines induce strong T cell response in blood cancer patients, irrespective of antibody response and B cell numbers.

30 Mar 2023

CD4 News and Research

HIV status does not affect Tecovirimat treatment outcomes for Mpox virus infection

Study identifies immune signature to predict severe COVID-19 in cardiovascular patients

Research identifies Th1 memory CD4+ T cells as key to protect against emerging poxvirus skin infections

Possible risk factors for brain aneurysm development in adults living with HIV

T cell-mediated recognition of conserved bacterial epitope generates broad immunity

Protective mucosal and systemic immunity provided by a single-dose novel live-attenuated intranasal SARS-CoV-2 vaccine candidate

Unlocking the potential of RNA lipid nanoparticles to revolutionize cancer treatment

Understanding human mycobiome commensalism and pathogenesis

Tissue-resident memory cells are key to immunity to Salmonella in mice

Vaccine component BNT162b4 enhances T-cell immunity against SARS-CoV-2 variants for reduced COVID-19 disease severity

Pregnant women show unique immune response to COVID-19

Daily statin medication could improve cardiovascular outcomes in people with HIV

COVID mRNA vaccines fall short in eliciting lung resident memory T cells compared to natural infection

Study assesses the cellular and molecular immunopathology of post-COVID lung disease

Researcher hypothesizes that overnutrition could lead to loss of self-tolerance by impinging on immune regulation

New therapeutic approach to eliminate aging cells by boosting anti-viral immune response

The breadth of immune responses following COVID-19 vaccination in hematology patients with diseases and treatments impacting B cell immunity

Diverse subset of T-cell clones plays a role in the antitumor effects of immune checkpoint inhibitors

Myeloid cells can harbor HIV in people taking antiretroviral therapy

Monocytes may be a stable reservoir of HIV in patients taking antiretroviral therapy

Discover how SciY empowers scientists

Why use light scattering to analyze proteins and viral vectors?

Changing the landscape of R&D to build clinical success from the ground up

Latest News