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Bacterial toxin shrinks tumors, enhances immune response in colorectal cancer study

A toxin secreted by cholera bacteria can inhibit the growth of colorectal cancer without causing any measurable damage to the body. This is shown by a new study by researchers at Umeå University, Sweden.

14 Jan 2026

Obesity study reveals gut fat's unique inflammatory role and immune cell richness

Abdominal fat is not a uniform tissue. A new study from Karolinska Institutet, Steno Diabetes Center Copenhagen, and Helmholtz Munich reveals that fat located close to the large intestine contains an unusually high number of inflammatory fat cells and immune cells.

13 Jan 2026

Study shows biosynthetic method to make low-calorie sugar substitute

From saccharin in the 19th century to stevia and monk fruit in the 21st, researchers and the food industry have long sought a sweetener that delivers the taste of sugar without its drawbacks-excess calories, tooth decay, and heightened risk for obesity, insulin resistance, and diabetes.

12 Jan 2026

Alliance trial tests proactive chemotherapy dose adjustments for GI cancers

To make cancer care smoother and more effective, the Alliance for Clinical Trials in Oncology has introduced a new clinical trial for people with gastrointestinal cancers, such as cancers of the stomach, colon, and esophagus.

12 Jan 2026

Targeting IDO1 for cancer: Novel degraders show promise in preclinical studies

Cancer cells employ a variety of strategies to evade the immune system, and modern immunotherapies aim precisely at these escape mechanisms.

9 Jan 2026

New research decodes the bacterial “zip code” of colorectal cancer for prediction and survival

Bacterial communities in colorectal cancer reveal patterns linked to tumor genetics and patient outcomes, paving the way for personalized treatment strategies.

From BGI Genomics 9 Jan 2026

Cornell-developed nanoparticles improve cancer immunotherapy effectiveness

A class of ultrasmall fluorescent core-shell silica nanoparticles developed at Cornell is showing an unexpected ability to rally the immune system against melanoma and dramatically improve the effectiveness of cancer immunotherapy, according to a new study led by Weill Cornell Medicine and Cornell Engineering researchers.

7 Jan 2026

$AGA's new update urges caution before surgical treatment of refractory constipation$

AGA's new update urges caution before surgical treatment of refractory constipation

A new update from the American Gastroenterological Association (AGA) is calling for greater caution before surgery is considered for patients with refractory constipation, a severe, chronic form of constipation that does not respond to standard treatments.

7 Jan 2026

The gut is not just digestive and new evidence shows it actively controls brain function

This comprehensive review synthesizes a decade of human and animal research to explain how the gut and brain communicate through hormonal, neural, immune, and microbial pathways. It highlights how disruptions in these pathways contribute to gastrointestinal, metabolic, and neurological disorders, and how modern therapies are beginning to exploit gut–brain signaling for clinical benefit.

6 Jan 2026

AI-designed molecular sensors could enable early detection of cancer

Detecting cancer in the earliest stages could dramatically reduce cancer deaths because cancers are usually easier to treat when caught early.

6 Jan 2026

Soft wireless bioelectronic implant targets the splenic nerve to reduce inflammation

For millions suffering from chronic inflammatory diseases like inflammatory bowel disease (IBD), managing flare-ups often involves powerful drugs with significant side effects.

1 Jan 2026

Prebiotic microcapsules deliver pterostilbene to the colon to alleviate ulcerative colitis

A team led by clinicians and engineers has wrapped the plant-derived polyphenol pterostilbene (PSB) into prebiotic alginate/resistant-starch microcapsules coated with chitosan and shown that oral administration dampens dextran-sulfate-sodium (DSS) colitis in mice.

23 Dec 2025

New open-source tool maps gene regulation networks in cancer

University of Navarra (Spain) researchers have developed RNACOREX, a new open-source software capable of identifying gene regulation networks with applications in cancer survival analysis.

19 Dec 2025

Estrogen drives gut pain and explains higher rates of IBS in women

Women are dramatically more likely than men to suffer from irritable bowel syndrome (IBS), a chronic condition causing abdominal pain, bloating, and digestive discomfort.

18 Dec 2025

Study finds a new protein target against KRAS-driven non-small cell lung cancer

Lung cancer is the second-most common cancer and the leading cause of cancer death in the United States.

18 Dec 2025

A multi-gene mouse model reveals new mechanisms of Hirschsprung disease

During development of the digestive system, a complex network of nerves forms around it, creating a "second brain" - the enteric nervous system (ENS) - which controls the movement of food and waste through the gut.

16 Dec 2025

First-of-its-kind mRNA system switches on therapeutic genes inside targeted cells

Researchers at the Icahn School of Medicine at Mount Sinai have developed a first-of-its-kind mRNA system that switches on therapeutic genes preferentially inside targeted cells-an advance demonstrated in studies in mice that could lay the groundwork for safer, more precise treatments for cancer and other diseases.

16 Dec 2025

New initiative aims to transform care for early-onset cancer patients

More people under age 50 are developing cancer, and with that comes a shift in the model of care needed to serve this unique cancer patient population – including early access to fertility counseling, universal genomic testing to identify underlying genetic drivers, support resources to address long-term survivorship considerations, and community education regarding early detection and screening.

15 Dec 2025

Advances in delivering oxygen-sensitive gut bacteria improve microbial therapies

Recent research has identified practical ways to protect and deliver oxygen-sensitive gut bacteria for a path toward safer, standardized microbial therapies that could reduce reliance on donor-based faecal microbiota transplants.

15 Dec 2025

Blood test identifies colon cancer patients who benefit from anti-inflammatory medication

A blood test could help doctors decide which patients with colon cancer should receive anti-inflammatory medication along with chemotherapy after surgery, according to new study in JAMA Oncology.

15 Dec 2025

Colon News and Research

Bacterial toxin shrinks tumors, enhances immune response in colorectal cancer study

Obesity study reveals gut fat's unique inflammatory role and immune cell richness

Study shows biosynthetic method to make low-calorie sugar substitute

Alliance trial tests proactive chemotherapy dose adjustments for GI cancers

Targeting IDO1 for cancer: Novel degraders show promise in preclinical studies

New research decodes the bacterial “zip code” of colorectal cancer for prediction and survival

Cornell-developed nanoparticles improve cancer immunotherapy effectiveness

AGA's new update urges caution before surgical treatment of refractory constipation

The gut is not just digestive and new evidence shows it actively controls brain function

AI-designed molecular sensors could enable early detection of cancer

Soft wireless bioelectronic implant targets the splenic nerve to reduce inflammation

Prebiotic microcapsules deliver pterostilbene to the colon to alleviate ulcerative colitis

New open-source tool maps gene regulation networks in cancer

Estrogen drives gut pain and explains higher rates of IBS in women

Study finds a new protein target against KRAS-driven non-small cell lung cancer

A multi-gene mouse model reveals new mechanisms of Hirschsprung disease

First-of-its-kind mRNA system switches on therapeutic genes inside targeted cells

New initiative aims to transform care for early-onset cancer patients

Advances in delivering oxygen-sensitive gut bacteria improve microbial therapies

Blood test identifies colon cancer patients who benefit from anti-inflammatory medication

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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