Metastasis News and Research

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Metastasis is the spread of cancer from one part of the body to another. A tumor formed by cells that have spread is called a “metastatic tumor” or a “metastasis.” The metastatic tumor contains cells that are like those in the original (primary) tumor. The plural form of metastasis is metastases

Beyond traditional models: 3D bioprinted tumor microenvironment unlocks resistance insights

Researchers developed a three-dimensional (3D) biologically printed in vitro model of the breast cancer tumor microenvironment.

28 Aug 2023

Study shows how cancer can selfishly hijack a helpful immune pathway to spread

A study led by researchers at Memorial Sloan Kettering Cancer Center (MSK) and Weill Cornell Medicine discovered a new relationship between cancer cells and the immune system, and shows how cancer can selfishly hijack a normally helpful immune pathway.

23 Aug 2023

New calculator predicts risk of early recurrence in patients with hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is the most commonly diagnosed cancer of the liver and the fourth leading cause of cancer-related mortality worldwide, with China accounting for over half of the global annual cases and deaths.

23 Aug 2023

Non-traditional gene fusions in luminal breast cancer: A new target for therapy

A new editorial paper was published in Oncotarget's Volume 14 on June 12, 2023, entitled, "Are cis-spliced fusion proteins pathological in more aggressive luminal breast cancer?"

21 Aug 2023

New insights into the role of liver progenitor cells in liver cancer initiation

Primary liver cancers ranked as the sixth most commonly diagnosed cancers and the third leading cause of cancer-related death in 2020. Among all primary liver cancers, HCC is the most common cancer, accounting for more than 80% of cases with a 5-year survival rate of less than 10% in Western countries.

17 Aug 2023

Copy number profiling provides insight as to why prostate cancer may become lethal

Researchers performed genome-wide copy number profiling of the androgen receptor (AR) on metastases from deceased prostate cancer patients.

16 Aug 2023

Scientists discover potential biomarkers linked to metastatic prostate cancer in Black men

Scientists at City of Hope, one of the largest cancer research and treatment organizations in the United States and a leading research center for diabetes and other life-threatening illnesses, have identified a cell metabolism process found in men with diabetes and metastatic prostate cancer that could one day lead to improved testing and treatments for Black men with these diseases.

15 Aug 2023

Epigenetic manipulation may improve breast cancer treatment responses

Researchers explore the possibility of increasing TROP2 ADC activity by enhancing the expression of TROP2 on cancer cells.

15 Aug 2023

Transparent crystal ribcage for real-time imaging of lung function

Researchers develop the ‘crystal ribcage,’ a transparent ribcage for real-time lung imaging at cellular resolution.

14 Aug 2023

New pathway for HIV to enter nucleus of healthy cells identified

A study published on August 10, 2023 in the journal Nature Communications has identified a new pathway that human immune deficiency virus (HIV) uses to enter the nucleus of a healthy cell, where it can then replicate and go on to invade other cells.

10 Aug 2023

How conversion between different types of cell death contributes to disease

Researchers elucidate the role of cell death in the pathogenesis of different diseases.

10 Aug 2023

GABA transfer between skin cells promotes melanoma initiation

The transfer of a neurotransmitter from one type of skin cell to another (melanocytes to keratinocytes) altered electrical activity and promoted melanoma initiation in preclinical models, according to results published in Cancer Discovery, a journal of the American Association for Cancer Research.

9 Aug 2023

Nanotechnology's triple threat: Advancing precision cancer treatment

The design of tumor tissue-, cell-, and organelle-targeted cancer nanomedicines.

9 Aug 2023

RAGE plays key role in cellular mechanisms of plasticity in aggressive triple-negative breast cancer

Published online ahead of print in the journal Oncogene , a study led by Josep Villanueva, an Investigator at the Vall d'Hebron Institute of Oncology (VHIO), shows that the receptor for advanced glycation end-product (RAGE) plays a key role in cellular mechanisms of plasticity in mesenchymal triple-negative breast cancer (TNBC) that transform epithelial cells into mesenchymal cells as potent drivers of cancer cell proliferation and tumor invasion.

8 Aug 2023

Bone mineralization found to dampen metastatic progression of breast cancer

Tumor cells are known to be fickle sleeper agents, often lying dormant in distant tissues for years before reactivating and forming metastasis.

7 Aug 2023

Recent advances in the understanding of the role and mechanism of CCAR2 in cancer

Researchers described the dual role of cell cycle and apoptosis regulator 2 (CCAR2) in cancer progression as a tumor suppressor and promoter.

4 Aug 2023

Gene expression ratio linked to prognosis in solid tumors

A Ludwig Cancer Research study has identified a pair of genes whose expression by a type of immune cell within tumors is predictive of outcomes for cancer patients and is linked to a vast network of gene expression programs, engaged by multiple cell types in the tumor microenvironment, that control human cancers.

3 Aug 2023