Retinoid News and Research

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Biomarker associated with poor outcome in aggressive childhood cancer

Results from a new study identify a biomarker that may be useful for predicting the outcome of treatment for neuroblastoma, the most common cancer in young children.

6 Apr 2009

Basilea Pharmaceutica expands potential commercial availability of Toctino in Europe

Basilea Pharmaceutica Ltd. has announced the submission of a Marketing Authorization Application (MAA) for Toctino (alitretinoin) in 13 additional European Union (EU) Member States as well as in Norway and Iceland. Toctino is a new once-daily oral treatment for adults with severe chronic hand eczema (CHE) unresponsive to potent topical corticosteroids.

31 Mar 2009

Dermatologists find new application for technique used to treat spider veins

Recent advances in skin rejuvenation can take years off one's appearance by softening or erasing fine lines and wrinkles, plumping sunken cheeks and erasing sun spots and uneven pigmentation.

5 Mar 2009

Cream containing tretinoin associated with death in clinical trial, but relationship does not appear causal

Patients using a cream containing tretinoin, a retinoid commonly used to treat acne and other conditions, appeared more likely to die than those using a placebo in a clinical trial that was halted early as a result, according to a report in the January issue of Archives of Dermatology.

19 Jan 2009

Chemical used in antifouling paints may promote obesity

Tributyltin, a ubiquitous pollutant that has a potent effect on gene activity, could be promoting obesity, according to an article in the December issue of BioScience.

1 Dec 2008

New stem cell tools to aid drug development

Scientists have designed, developed and tested new molecular tools for stem cell research to direct the formation of certain tissue types for use in drug development programmes.

2 Sep 2008

Cosmecueticals improve skin

Cosmecueticals, beauty aids that reportedly work like prescription drugs, are providing new ways to treat aging skin.

2 Jan 2008

Vitamin A derivative associated with reduced growth in some lung cells

Treatment with a derivative of vitamin A called retinoic acid was associated with reduced lung cell growth in a group of former heavy smokers, according to a study published online October 30 in the Journal of the National Cancer Institute.

31 Oct 2007

New strategies with greater antitumorous efficacy

One of the biggest problems in the current treatment of cancer is that the agents that are efficacious in the destruction of tumorous cells are, at the same time, extremely toxic for the rest of the healthy cells and tissues of the patient.

3 Oct 2007

New lung cancer guidelines say forget scans and chest X-rays

The American College of Chest Physicians (ACCP), is advising against low-dose CT scanning or chest X-rays to screen for lung cancer.

12 Sep 2007

Most comprehensive recommendations related to lung cancer

New evidenced-based guidelines from the American College of Chest Physicians (ACCP) recommend against the use of low-dose computed tomography (LDCT) for the general screening of lung cancer.

11 Sep 2007

New oral acne medications work best

While laser and light-based therapies continue to make their mark on many dermatologic procedures, some dermatologists believe the tried-and-true oral medications for treating moderate to severe acne offer patients the best long-term treatment outcomes.

2 Aug 2007

New insights into acute promyelocytic leukemia

Results from two new studies provide key mechanistic insights into the complex molecular events that cause a deadly type of leukemia.

10 Jul 2007

Current status of neuroblastoma treatment and trends for the near future

Childhood cancers are fortunately rare, but among them, neuroblastoma is a special case, accounting for 7 percent of all childhood cancers, but 15 percent of childhood cancer deaths.

23 Jun 2007

FDA approves Differin (adapalene) gel, 0.3% for acne

Galderma Laboratories, L.P., has announced that the U.S. Food and Drug Administration (FDA) has approved Differin (adapalene) Gel, 0.3%, a new, higher concentration formulation of Differin (adapalene) 0.1%, a topical retinoid indicated for the treatment of acne.

23 Jun 2007

Acne drug leads to depression-related behavior in mice

A drug commonly used to treat severe acne can lead to depression-related behavior in mice, according to research published in the journal Neuropsychopharmacology by scientists from The University of Texas at Austin and the University of Bath.

21 Sep 2006

Acne drug Roaccutane linked to depression

A drug commonly used to treat severe acne can lead to depressive behaviour in mice, according to research published in the journal Neuropsychopharmacology.

19 Sep 2006

DARPA grant supports research toward realizing tissue regeneration

While U.S. soldiers fighting in Iraq and Afghanistan are surviving injuries that in previous conflicts likely would have been fatal, the number of wounded with major tissue loss has never before been so high.

3 May 2006

Trial of low-dose Isotretinoin for prevention of second primary tumors in head and neck cancer patients

Taking a vitamin A derivative called isotretinoin did not reduce the risk of second primary tumors or improve survival in patients with stage I or II head and neck squamous cell cancers (HNSCC), according to a study in the Journal of the National Cancer Institute.

13 Apr 2006

Why males produce sperm and females produce eggs

An Australian research team has solved one of biology's most fundamental questions - why males produce sperm and females produce eggs. The finding is a breakthrough that could lead to improved infertility treatment, cancer therapy and pest management.

4 Apr 2006