Xenograft News and Research

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Xenograft are the cells of one species transplanted to another species.

Researchers establish organoid culture models from prostate tumor biopsies

Scientists at Urology Research Laboratory of the Department for BioMedical Research, University of Bern and Urology Department of the Inselspital of Bern, have established organoid culture models from prostate tumor biopsies.

8 Mar 2021

Xenograft model for invasive lobular carcinoma simulates tumor with high accuracy

Invasive lobular carcinoma (ILC) is a type of breast cancer that begins in the milk-producing glands (lobules) of the breast.

22 Feb 2021

Trispecific antibody targets cancer cells, natural killer cells

Several treatments for cancer have been devised by science, but unfortunately none of them are completely efficient or foolproof.

19 Feb 2021

Toward patient-derived models to help personalize cancer care

Cancer is a major, worldwide challenge, and its impact is projected to escalate due to aging and growth of the population.

21 Jan 2021

Proteogenomics can help determine effective treatment for head and neck squamous cell carcinoma

Proteogenomic analysis may offer new insight into matching cancer patients with an effective therapy for their particular cancer.

7 Jan 2021

New class of targeted cancer drugs may prove effective in treating common types of leukemia

A new study by researchers in Cleveland Clinic's Taussig Cancer Institute and Lerner Research Institute describes a novel class of targeted cancer drugs that may prove effective in treating certain common types of leukemia.

15 Dec 2020

Preliminary analysis of xenograft versus organoids

The observance of Lung Cancer Awareness Month in November affords an opportunity to take stock of current approaches to lung cancer research, and to cancer research more widely.

11 Nov 2020

Scientists develop new type of precise therapeutic vaccine against leukemia

Exploration of new leukemia antigens and construction of appropriate delivery systems using FDA-approved material are important strategies for developing leukemia vaccines for clinic use.

12 Oct 2020

Study: Pleotropic drugs can have both favorable and unfavorable effects on cell growth, survival

The cover for issue 37 of Oncotarget features Figure 7, "The combination of romidepsin and KU60019 is synergistic in a xenograft model of MCL," by Scotto, et al. which reported that the antiproliferative effect induced by histone deactylase inhibitors is associated with the up-regulated expression of the cyclin-dependent kinase inhibitor p21.

17 Sep 2020

Study sheds new light on function and regulation of APOBEC3B in adrenocortical carcinoma

The cover for issue 36 of Oncotarget features, "Knockdown of APOBEC3B is associated with a lower tumor growth in an adrenocortical carcinoma xenograft mouse model," by Gara, et al. which reported that the role of APOBEC3B in adrenocortical carcinoma and the mechanisms through which its expression is regulated in cancer are not fully understood.

9 Sep 2020

Exosomes: The cancer cell communication mechanism

Professor Deborah Goberdhan speaks to News-Medical about her team's latest research into cancer cells, and the mechanisms they use to communicate.

26 Aug 2020

New type of immunotherapy extends survival of mice with triple negative breast tumors

Immunotherapies for cancer - treatments that prime the immune system to attack tumors - are valuable weapons in the anti-cancer arsenal. But some cancers are more difficult to target with this strategy than others.

17 Aug 2020

SPT enzyme can be used as metabolically responsive “switch” to slow tumor growth

The enzyme serine palmitoyl-transferase can be used as a metabolically responsive "switch" that decreases tumor growth, according to a new study by a team of San Diego scientists, who published their findings Aug. 12 in the journal Nature.

12 Aug 2020

New alpha-radioimmunotherapy for multiple myeloma shows promise in preclinical study

A new alpha-radioimmunotherapy, 212Pb-anti-CD38, has proven effective in preventing tumor growth and increasing survival in multiple myeloma tumor-bearing mice, according to new research published in the July issue of the Journal of Nuclear Medicine. Given the long half-life, central production and worldwide distribution of 212Pb-anti-CD38, researchers have determined that the α-radioimmunotherapy is not only effective but also clinically feasible as a multiple myeloma treatment.

6 Aug 2020

Xenograft News and Research

Researchers establish organoid culture models from prostate tumor biopsies

Xenograft model for invasive lobular carcinoma simulates tumor with high accuracy

Trispecific antibody targets cancer cells, natural killer cells

Toward patient-derived models to help personalize cancer care

Proteogenomics can help determine effective treatment for head and neck squamous cell carcinoma

New class of targeted cancer drugs may prove effective in treating common types of leukemia

Preliminary analysis of xenograft versus organoids

Scientists develop new type of precise therapeutic vaccine against leukemia

Study: Pleotropic drugs can have both favorable and unfavorable effects on cell growth, survival

Study sheds new light on function and regulation of APOBEC3B in adrenocortical carcinoma

Exosomes: The cancer cell communication mechanism

New type of immunotherapy extends survival of mice with triple negative breast tumors

SPT enzyme can be used as metabolically responsive “switch” to slow tumor growth

New alpha-radioimmunotherapy for multiple myeloma shows promise in preclinical study

Computational modeling enables accurate visualizations of heart valve behavior

Study identifies phosphorylation-based biomarkers to guide cancer therapy

Exploiting 'synthetic lethality' to identify cancer targets

Gene signature explains why 18F-FDG imaging performs better for PSMA-suppressed prostate cancer patients

New theranostic agents show efficacy for precision diagnosis, treatment of prostate cancer

St. Jude scientists create O-PDX models for pediatric brain tumor research

Event guide: 4th Extra-Hepatic Lipid-Based Nanoparticles Delivery Summit eBook

Advancing Intracellular Delivery with LumiPore®

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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