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InnaVirVax announces Phase I/IIa clinical trial authorization for its VAC-3S HIV vaccine

InnaVirVax, a biopharmaceutical company dedicated to the development of therapeutic and diagnostic solutions in pathologies associated with immune dysregulation, declared today that it has obtained authorization from the French drug agency (AFSSAPS) to start a Phase I/IIa clinical study of its therapeutic vaccine VAC-3S for the treatment of HIV infections. This authorization intervenes only two years and half after the launching of InnaVirVax’s activities.

14 Oct 2011

96% Campaign asks Obama to 'pay attention to science' and scale up global access to ARVs

In this RH Reality Check opinion piece, Matthew Kavanagh, director of U.S. advocacy at Health GAP (Global Access Project), and Dazon Dixon Diallo, founder and president of SisterLove, Incorporated, write, "With proof that treatment is prevention, and with this basket of broader prevention options, scientists and economists have finally been able to show what few could before: models of how we end the AIDS crisis."

11 Oct 2011

NIH awards LSUHSC $9 million grant to develop pneumonia vaccine

Dr. Judd Shellito, Chief of the Section of Pulmonary and Critical Care Medicine at LSU Health Sciences Center New Orleans, has been awarded approximately $9 million in grant funding to develop a vaccine against Pneumocystis, an important cause of pneumonia in people with HIV infection. This potentially fatal illness is the most common serious opportunistic infection in people with HIV.

7 Oct 2011

PEPFAR ART cost model data presented to PEPFAR Scientific Advisory Board

"For every 1,000 patient-years of PEPFAR-supported HIV treatment provided, 228 fewer HIV patients die, 449 fewer children become orphans, 61 fewer sexual HIV transmissions occur and 26 fewer 'vertical' transmissions (e.g. mother-to-child) occur," John Blanford of the CDC told the PEPFAR Scientific Advisory Board in Washington, D.C., on September 14, according to a post in the Center for Global Health Policy's "Science Speaks" blog.

7 Oct 2011

Scientists discover two HIV variants in cerebrospinal fluid of HAD patients

When the virus that causes AIDS infects the central nervous system, it can lead to the development of a severe neurological disease called HIV- associated dementia.

7 Oct 2011

Keeping HIV patients on ART will have long-term economic benefits, study shows

Investments to keep 3.5 million people living with HIV on antiretroviral drugs provided by programs co-financed through the Global Fund to Fight AIDS, Tuberculosis and Malaria through 2020 will cost an estimated $14.2 billion, but "the financial savings would amount to between $12 billion and $34 billion," according to a study published in the journal PLoS One, Sarah Boseley reports in her "Global Health Blog" in the Guardian.

7 Oct 2011

Addressing high-risk groups, couples counseling in HIV prevention

In this post in the Center for Global Development's "Global Health Policy" blog, Mead Over, a senior fellow at the center, follows up on a post last week in which he wrote that a panel of senior economists commissioned by the Rush Foundation was to address the question of how to spend an additional, but hypothetical, $10 billion on HIV/AIDS programs in Africa over the next five years.

4 Oct 2011

Bristol-Myers to present abstracts on research in liver disease at The Liver Meeting 2011

Bristol-Myers Squibb Company announced today that 22 abstracts on the Company's research in liver disease have been accepted for presentation at The Liver Meeting 2011, the 62nd annual meeting of the American Association for the Study of Liver Diseases, in San Francisco, November 4 - 8.

1 Oct 2011

USAID interviews Kenyan government staff regarding Cabinet memorandum outlining HIV program fundraising options

USAID's "IMPACTblog" interviews Regina Ombam, head of strategy for the Kenya National AIDS Control Council (NACC), and Irene Mukui, the antiretroviral therapy (ART) program manager for Kenya's National AIDS and STI Control Program, regarding a Cabinet memorandum prepared by the NACC in March that outlines ways to raise funds for HIV programming.

1 Oct 2011

Microbicide Trials Network stops tenofovir arm of study after findings show drug less effective than anticipated

"The Microbicide Trials Network (MTN), which is funded by the U.S. National Institutes of Health, on Wednesday announced that it decided to stop one arm of a study involving more than 5,000 women in South Africa, Zimbabwe, and Uganda" after "an interim review of the ongoing trial by an independent monitoring board found that the drug tenofovir when used as pre-exposure prophylaxis (PrEP) had less effect in protecting women than anticipated," Science Magazine's "Science Insider" blog reports.

30 Sep 2011

Oral tenofovir discontinued in HIV clinical trial

A large-scale clinical trial evaluating whether daily use of an oral tablet or vaginal gel containing antiretroviral drugs can prevent HIV infection in women is being modified because an interim review found that the study cannot show that one of the study products, oral tenofovir, marketed under the trade name Viread, is effective.

29 Sep 2011

VOICE HIV prevention trial to discontinue use of tenofovir tablets

VOICE, an HIV prevention trial evaluating two antiretroviral (ARV)-based approaches for preventing the sexual transmission of HIV in women - daily use of one of two different ARV tablets or of a vaginal gel - will be dropping one of the oral tablets from the study.

29 Sep 2011

'Urgent action' needed to prevent resistance to antiretroviral therapy

"The clear pattern of increasing antiretroviral resistance in lower-income settings must be considered in the context of the worldwide HIV-control agenda," especially because "the increasing rates of antiretroviral resistance in low-income settings represent a potential threat to the emerging treatment-as-prevention strategy," Evan Wood and Julio Montaner of the BC Centre for Excellence in HIV/AIDS write in a Lancet Infectious Diseases opinion piece.

28 Sep 2011

Study sheds light on when to start antiretroviral therapy

Findings from a study published in the current issue of the journal Archives of Internal Medicine, when "taken together with other studies published over the last few years," show that beginning people living with HIV on highly active antiretroviral therapy (HAART) when their CD4 cell count is between 350 and 500 "appears to be beneficial over the long term.

28 Sep 2011

URBAN ARCH Consortium to examine consequences of alcohol on HIV disease

Researchers from Boston University Schools of Medicine and Public Health (BUSM/BUSPH), Boston Medical Center (BMC), the University of California, San Francisco and the University of Pittsburgh, have joined together to examine the consequences of alcohol on HIV disease.

27 Sep 2011

Gilead announces EMA CHMP positive opinion for HIV-1 drug, Eviplera

Gilead Sciences, Inc. today announced that the Committee for Medicinal Products for Human Use (CHMP), the scientific committee of the European Medicines Agency, has adopted a positive opinion on the company's Marketing Authorisation Application for the once-daily single-tablet regimen, Eviplera.

23 Sep 2011

National HIV/AIDS Strategy meeting to be held at UAB

The White House Office of National AIDS Policy is holding a series of National HIV/AIDS Strategy Implementation Dialogues across the country to examine critical issues and encourage action and collaboration at the state and local levels. The first meeting, focusing on incorporating prevention and care research into HIV programs, is being held at the University of Alabama at Birmingham on Tuesday, Sept. 27, 2011.

23 Sep 2011

HSPH receives CDC grant to evaluate HIV combination prevention initiative in Botswana

A new four-year, $20 million grant from the U.S. Centers for Disease Control and Prevention (CDC) will enable Harvard School of Public Health (HSPH) researchers to evaluate the impact and cost-effectiveness of a unique combination of HIV prevention strategies in Botswana.

22 Sep 2011

Early ART cost effectiveness in resource-poor settings

A study published in PLoS Medicine shows "that the new WHO guidelines for early [antiretroviral treatment (ART)] initiation can be cost-effective in resource-poor settings, information that should help policymakers in developing countries allocate their often limited resources," according to a PLoS press release.

22 Sep 2011

Early ART can be cost-effective and decrease mortality in HIV patients

Researchers at Weill Cornell Medical College and GHESKIO have shown that early treatment of HIV not only saves lives but is also cost-effective. Results are published in today's edition of PLoS Medicine.

22 Sep 2011