Endoplasmic reticulum (ER) News and Research

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Key signs of appendicitis

A 5-year-old with abdominal pain, nausea and fever may have appendicitis or any of a number of other problems.

3 Aug 2007

Test scores were stronger before 'No Child Left Behind' was approved in 2002

As Congress reviews federal efforts to boost student performance, new research published in Educational Researcher (ER) reports that progress in raising test scores was stronger before No Child Left Behind was approved in 2002, compared with the four years following enactment of the law.

1 Aug 2007

Court rules in favor of Sandoz on Toprol Xl patent

Sandoz was pleased to learn this week that the U.S. Court of Appeals in St. Louis has affirmed a summary judgment by U.S. District Judge Rodney Sippel invalidating patent protection on Toprol XL(R), a beta blocker used to treat angina, heart failure, and high blood pressure.

26 Jul 2007

Group therapy does not prolong the lives of women with metastatic breast cancer

Earlier results from the same researcher had suggested a survival benefit of group therapy for women with metastatic breast cancer. However, the new study did find that women with estrogen receptor (ER) negative tumors did show survival benefit, and that group therapy improved quality of life (QOL).

23 Jul 2007

Cholesteryl ester transfer protein may also influence how fat cells store fat

Scientists have shown for the first time that a protein involved in the transfer of fat in the blood may also influence how fat cells store fat.

20 Jul 2007

Continuous support for women during childbirth

When it comes to giving birth, some traditional approaches could result in happier and healthier moms and newborns, according to two research reviews.

18 Jul 2007

Src inhibitors may prove beneficial in breast cancer therapy

Estrogen, which binds estrogen receptor alpha (ER-alpha), is a risk factor for breast cancer development.

13 Jul 2007

High-tech dental lasers eliminate bacteria in root canals

High-tech dental lasers used mainly to prepare cavities for restoration now can help eliminate bacteria in root canals, according to research published in the July issue of The Journal of the American Dental Association (JADA).

13 Jul 2007

Hormone therapy can extend life in ovarian cancer patients

The study, published in Clinical Cancer Research, has proved for the first time that the targeted use of an anti-oestrogen drug could prolong the life of some patients by up to three years, and delay the use of chemotherapy in others.

17 Jun 2007

Researchers find new mechanism of action of the anti-cancer drug sorafenib

Virginia Commonwealth University Massey Cancer Center researchers have uncovered a new mechanism of action of the anti-cancer drug sorafenib, which could stimulate the development of novel regimens in which it is combined with other molecularly targeted agents for patients with blood cancers and solid tumors.

15 Jun 2007

MRI detects cancers missed by mammography in breast cancer patients

A unique examination of one treatment center's use of magnetic resonance imaging (MRI) in new breast cancer patients has found MRI to be superior to mammography in finding additional tumors in a breast in which cancer has already been diagnosed, and in detecting new tumors in a patient's supposedly healthy breast.

5 Jun 2007

Physiological differences between men and women impact colorectal cancer progression

Physiological differences between men and women may contribute to differential tumor development and progression in colon cancer patients, a study led by researchers at the University of Southern California (USC) suggests.

5 Jun 2007

Benefits of Herceptin are lasting

An updated analysis of two large randomized clinical trials has found that breast cancer patients who received the monoclonal antibody trastuzumab (Herceptin) along with chemotherapy are living longer and with less risk of recurrent disease, compared to patients treated with chemotherapy alone.

5 Jun 2007

New discoveries on genes implicated in Fanconi anaemia

An international research consortium, which included the participation of the Mutagnesi Group from the UAB, has made outstanding progress in the study of Fanconi anaemia.

3 Jun 2007

Obese people more likely to have persistent or severe persistent asthma

A new study presented at the American Thoracic Society 2007 International Conference finds that obese people are significantly more likely to have persistent or severe persistent asthma than their thinner counterparts.

24 May 2007

Promoter hypermethylation is common in breast cancer

Cancer epidemiologists at the University at Buffalo have identified specific genes that are most likely to become cancer promoters when exposed to a process called DNA promoter hypermethylation.

17 May 2007

Specific genes identified that are most likely to become cancer promoters when exposed to DNA promoter hypermethylation

Hypermethylation is a process that causes genes that promote normal cell growth to produce proteins that cause malignant behavior, or unregulated cell growth. Until now, data has been very limited regarding the mechanism and causes of hypermethylation, especially for hypermethylation in breast cancer.

15 May 2007

Influence of the cellular microenvironment on breast cancer

This month The American Journal of Pathology highlights the influence of the cellular microenvironment on breast cancer by promoting three articles from the current issue.

27 Apr 2007

Succimer therapy improves balance and movement in lead-exposed children

University of Cincinnati (UC) environmental health researchers say a therapy commonly used to remove dangerously high levels of lead from the body may also improve muscle functions associated with postural balance and movement in lead-exposed children.

25 Apr 2007

Decrease in breast cancer incidence linked to drop in HRT

A special report in the April 19, 2007 edition of The New England Journal of Medicine concludes that the sharp decline in breast-cancer incidence in 2003, followed by a relative stabilization at a lower rater in 2004, is most likely related to the first report of the Women's Health Initiative (WHI).

19 Apr 2007