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Study illustrates how a protein complex controls genome organization to maintain lineage fidelity

Understanding the molecular mechanisms that specify and maintain the identities of more than 200 cell types of the human body is arguably one of the most fundamental problems in molecular and cellular biology, with critical implications for the treatment of human diseases. Central to the cell fate decision process are stem cells residing within each tissue of the body.

29 Apr 2022

Yale researchers identify immune system culprit in severe COVID cases

Yale researchers have identified a particular immune response pathway that leads to severe illness and death in people infected by the SARS-CoV-2 virus.

28 Apr 2022

New insights could lead to better treatments for Dravet syndrome and related conditions

Children with Dravet syndrome, a severe form of epilepsy that begins in infancy, experience seizures, usually for their entire life.

27 Apr 2022

Penn scientists discover how one inflammatory disorder increases susceptibility to another

The immune system remembers. Often this memory, primed by past encounters with threats like bacteria or viruses, is an asset. But when that memory is sparked by internal drivers, like chronic inflammation, it can prove detrimental, perpetuating a misguided immune response.

27 Apr 2022

Genetic cause of lupus identified

An international team of researchers has identified DNA mutations in a gene that senses viral RNA, as a cause of the autoimmune disease lupus, with the finding paving the way for the development of new treatments.

27 Apr 2022

Gene discovery could pave the way for new and more effective treatments for lupus

Researchers from The Australian National University have identified a gene called TLR7 that, when over-activated, is responsible for causing lupus, an autoimmune disease that can be life-threatening in severe cases.

27 Apr 2022

Researchers use mouse model to explore correlation of impaired interferon-mediated immune response with severe COVID-19

Researchers developed a highly pathogenic mouse-adapted SARS-CoV-2 strain to model mild, moderate, or COVID-19.

26 Apr 2022

MCG scientists report how exercise can counter the damage of diabetes

One way exercise can counter the damage of diabetes is by enabling activation of a natural system we have to grow new blood vessels when existing ones are ravaged by this disease, scientists report.

26 Apr 2022

A novel mouse model to test SARS-CoV-2 viral infection

In a recent study posted to the Research Square* preprint server, researchers developed a novel mouse model for testing infection by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2).

26 Apr 2022

Glucose-lowering treatments may be effective in improving response to exercise training

Exercise carries a long list of benefits for everyone. For people with metabolic diseases like pre-diabetes, type 1 diabetes and type 2 diabetes, physical activity can help keep blood sugar levels in check and stave off diabetes-related nerve damage and heart disease.

25 Apr 2022

Study demonstrates that a low-dose, bivalent, unmodified mRNA vaccine against SARS-CoV-2 is highly efficacious

Researchers compared the efficiency of monovalent and bivalent mRNA vaccines against SARS-CoV-2.

22 Apr 2022

Scientists identify innovative treatment approach for arterial thromboses

Scientists have shown in an animal model that the CXCL12 messenger could be suitable as a target structure for the treatment of blood-clotting disorders.

21 Apr 2022

Abnormalities in astrocytes may play a key role in causing autism spectrum disorder symptoms

Abnormalities in a type of brain cell called astrocytes may play a pivotal role in causing some behavioral symptoms of autism spectrum disorders, according to a preclinical study by Weill Cornell Medicine investigators.

21 Apr 2022

Using CR2Crry to reduce the negative effects of brain hemorrhaging in premature infants

A little over 1% of babies born in the U.S. in 2020 fell under the category of very low birthweight, meaning they weighed less than 1,500 grams at birth or 3 pounds, 4 ounces. And considering that the Centers for Disease Control and Prevention says more than 3.5 million babies were born that year, almost 48,500 were considered to be at very low birthweight.

21 Apr 2022

New evidence from a zebrafish model may help understand how epileptic seizures originate

New evidence from a zebrafish model of epilepsy may help resolve a debate into how seizures originate, according to Weill Cornell Medicine and NewYork-Presbyterian investigators.

20 Apr 2022

A new approach for treating multiple-drug resistant bacteria

Antibiotic-resistant hospital pathogens are not to be underestimated as a health risk. A research team has now introduced a new approach for treating multiple-drug resistant Staphylococcus in the journal Angewandte Chemie.

20 Apr 2022

Type I interferon found to be major driver of memory, cognitive loss in Alzheimer's disease mouse model

Alzheimer's disease (AD), the most common type of dementia, progressively impairs memory, concentration and the ability to learn new things and accomplish everyday activities.

19 Apr 2022

Levels of little-studied enzyme found to decline with age and more dramatically with Alzheimer’s

A little-studied enzyme has been found in high levels in healthy neurons, levels that scientists say decline with age and more dramatically with Alzheimer's, making adjusting the enzyme's level a potential treatment for both.

19 Apr 2022

Researchers reveal possible way to treat newborns with rare genetic lung condition

When babies are born with alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV), their skin starts to turn blue from the under-oxygenated blood in their systems.

19 Apr 2022

Inhibiting key signaling pathway in immune cells may slow down Alzheimer's disease

Inhibiting an important signaling pathway in brain-resident immune cells may calm brain inflammation and thereby slow the disease process in Alzheimer's and some other neurodegenerative diseases, suggests a study by Weill Cornell Medicine investigators.

14 Apr 2022

Mouse Model News and Research

Study illustrates how a protein complex controls genome organization to maintain lineage fidelity

Yale researchers identify immune system culprit in severe COVID cases

New insights could lead to better treatments for Dravet syndrome and related conditions

Penn scientists discover how one inflammatory disorder increases susceptibility to another

Genetic cause of lupus identified

Gene discovery could pave the way for new and more effective treatments for lupus

Researchers use mouse model to explore correlation of impaired interferon-mediated immune response with severe COVID-19

MCG scientists report how exercise can counter the damage of diabetes

A novel mouse model to test SARS-CoV-2 viral infection

Glucose-lowering treatments may be effective in improving response to exercise training

Study demonstrates that a low-dose, bivalent, unmodified mRNA vaccine against SARS-CoV-2 is highly efficacious

Scientists identify innovative treatment approach for arterial thromboses

Abnormalities in astrocytes may play a key role in causing autism spectrum disorder symptoms

Using CR2Crry to reduce the negative effects of brain hemorrhaging in premature infants

New evidence from a zebrafish model may help understand how epileptic seizures originate

A new approach for treating multiple-drug resistant bacteria

Type I interferon found to be major driver of memory, cognitive loss in Alzheimer's disease mouse model

Levels of little-studied enzyme found to decline with age and more dramatically with Alzheimer’s

Researchers reveal possible way to treat newborns with rare genetic lung condition

Inhibiting key signaling pathway in immune cells may slow down Alzheimer's disease

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