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Researchers explore the genetic roots of congenital diaphragmatic hernias

To breathe normally, people need more than just healthy lungs. A diaphragm - the large muscle that creates a vacuum to draw air into their lungs - is also crucial.

16 Jun 2005

Inactive gene may explain higher incidence of prostate cancer in African-Americans compared to Caucasians

Among African-Americans with prostate cancer, a tumor-suppressing gene called GSTP1 is inactivated at a rate 3.5 times higher than among Caucasians, according to a study conducted at the San Francisco VA Medical Center (SFVAMC).

16 Jun 2005

Scientists have tracked down the biological trigger that gives rise to Van Buchem disease

...a hereditary, disfiguring bone disorder that can cause blindness and deafness. The findings provide insight into long-range gene regulation and could lead to new treatments for osteoporosis and other crippling bone disorders.

16 Jun 2005

Hydroxyurea may prevent complications such as organ damage and stunted growth in treatment of sickle cell disease

Treating babies who have sickle cell disease (SCD) with oral liquid hydroxyurea appears to prevent the onset of long-term complications triggered by this disease, according to results of a preliminary study by investigators at St. Jude Children's Research Hospital.

16 Jun 2005

First human case of bird flu found in Indonesia

The World Health Organization (WHO) has reported that the first human case of bird flu has been diagnosed in Indonesia.

16 Jun 2005

Jumping genes help detemine uniqueness of individual brains

Scientists at the Salk Institute for Biological Studies may have found one explanation for the puzzling variety in brain organization and function: mobile elements, pieces of DNA that can jump from one place in the genome to another, randomly changing the genetic information in single brain cells.

15 Jun 2005

Oral liquid Hydroxyurea promising for long-term use in babies with sickle cell disease

15 Jun 2005

Six new bird flu cases in Vietnam

Another six cases of bird flu have been reported in Vietnam, taking the total since December 2004 to 61. Of these 18 have died.

15 Jun 2005

New genetic test may detect risk of malignant hyperthermia (MH) from anesthesia

A rare but potentially life-threatening inherited condition called malignant hyperthermia (MH) may strike surgical patients who receive common drugs for general anesthesia.

14 Jun 2005

Study examines biomarkers for response to erlotinib in glioma

Researchers have found two biomarkers that, in patients with a malignant type of brain tumor called glioblastoma multiforme, were associated with response to the cancer drug erlotinib (Tarceva).

14 Jun 2005

New genetic test may detect risk of rare complication from anesthesia

A rare but potentially life- threatening inherited condition called malignant hyperthermia (MH) may strike surgical patients who receive common drugs for general anesthesia.

14 Jun 2005

Chemotherapy for brain tumors is boosted after vaccine targets resistance-related TRP-2 antigen

In the August issue of the journal Oncogene, researchers at Cedars-Sinai Medical Center's Maxine Dunitz Neurosurgical Institute describe a molecular mechanism that appears to make malignant brain tumors more vulnerable to chemotherapy after they have been treated with the dendritic cell vaccine.

13 Jun 2005

Researchers may be on the verge of exploiting the vulnerabilities of a virus that causes cervical cancer

Researchers may be on the verge of exploiting the vulnerabilities of a virus that causes cervical cancer, thanks to a newly developed technique that enables scientists to mass-produce human papillomavirus (HPV) in the laboratory.

13 Jun 2005

Novel and more effective way of testing which gene mutations cause cancer

Often cancer research goes like this: study cancerous cells in a lab dish, find mutations that appear in many of the samples, develop drugs to target proteins made by the mutated genes, and voila, new chemotherapy drugs are born. Or at least that's the hope.

12 Jun 2005

Researchers discover how microRNA are involved in the development of heart muscle

Researchers at UT Southwestern Medical Center have discovered how a small molecule of RNA called microRNA - a chemical cousin of DNA - helps fine tune the production of a key protein involved in the early development of heart muscle.

12 Jun 2005

Bio-engineered skin provides clues to melanoma development

When it comes to the deadly skin cancer melanoma, studying functional tissue rather than cell lines may better provide insight into the disease's development, according to new research from a Howard Hughes Medical Institute predoctoral fellow at Stanford University School of Medicine.

12 Jun 2005

Finding could provide targets for diagnosis, prognosis, therapy of prostate cancer

Researchers led by Dr. Shiv Srivastava from the Center for Prostate Disease Research (CPDR), Uniformed Services University of the Health Sciences (USU), report the groundbreaking discovery of the ETS-Related Gene (ERG) as one of the frequent proto-oncogene overexpressions in prostate cancer cells.

10 Jun 2005

Researchers use RNAi libraries to identify regulators of apoptosis and chemoresistance

Using targeted RNA interference, or RNAi libraries, researchers at Harvard Medical School describe the first large-scale classification of kinase and phosphatase gene families on the basis of their role in apoptosis and cell survival. This study appears in the June issue of Nature Cell Biology.

10 Jun 2005

DNA discovery may help explain disorders such as autism

Researchers have made a discovery that may in future help to explain many aspects of human social behavior and disorders such as autism.

10 Jun 2005

Researchers discover how hepatic-C virus evades immune system in acute and chronic infections

Researchers at Johns Hopkins have uncovered how a majority of the genetic changes in the hepatic-C virus, the most common cause of liver disease, allow it to evade the body's immune system during infection.

10 Jun 2005

Mutation News and Research

Researchers explore the genetic roots of congenital diaphragmatic hernias

Inactive gene may explain higher incidence of prostate cancer in African-Americans compared to Caucasians

Scientists have tracked down the biological trigger that gives rise to Van Buchem disease

Hydroxyurea may prevent complications such as organ damage and stunted growth in treatment of sickle cell disease

First human case of bird flu found in Indonesia

Jumping genes help detemine uniqueness of individual brains

Oral liquid Hydroxyurea promising for long-term use in babies with sickle cell disease

Six new bird flu cases in Vietnam

New genetic test may detect risk of malignant hyperthermia (MH) from anesthesia

Study examines biomarkers for response to erlotinib in glioma

New genetic test may detect risk of rare complication from anesthesia

Chemotherapy for brain tumors is boosted after vaccine targets resistance-related TRP-2 antigen

Researchers may be on the verge of exploiting the vulnerabilities of a virus that causes cervical cancer

Novel and more effective way of testing which gene mutations cause cancer

Researchers discover how microRNA are involved in the development of heart muscle

Bio-engineered skin provides clues to melanoma development

Finding could provide targets for diagnosis, prognosis, therapy of prostate cancer

Researchers use RNAi libraries to identify regulators of apoptosis and chemoresistance

DNA discovery may help explain disorders such as autism

Researchers discover how hepatic-C virus evades immune system in acute and chronic infections

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

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A New Approach to Preventing Bladder Cancer Recurrence

Bringing real-time analytics to downstream bioprocess monitoring

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