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Human RecQ helicases, homologous recombination and genomic instability

Two independent papers in the December 1st issue of G&D detail how human RecQ helicases regulate homologous recombination and protect genome stability.

15 Nov 2007

New explanation for how regulatory networks of genes evolved

When ancient retroviruses slipped bits of their DNA into the primate genome millions of years ago, they successfully preserved their own genetic legacy.

15 Nov 2007

WaferGen and University of Pittsburgh to collaborate on SmartChip

WaferGen Biosystems, Inc. has announced that it has established a research collaboration with the University of Pittsburgh Medical School to have it serve as the alpha test site for WaferGen's SmartChip Real-Time PCR System.

14 Nov 2007

New genetic lineage of Ebola virus discovered in great apes

The Zaire species of Ebolavirus (ZEBOV) remains the most virulent of the various known species. It alone is responsible for 88% of human deaths from haemorrhagic fever recorded since Ebola's discovery in 1976.

13 Nov 2007

Human Genome Sciences announces positive phase 2 LymphoStat-B results

Human Genome Sciences, Inc. has announced the presentation of Phase 2 clinical results demonstrating that LymphoStat-B (belimumab) achieved a sustained improvement in disease activity across multiple clinical measures, decreased the frequency of disease flares over time, and was well tolerated through 2.5 years on treatment in combination with standard of care in patients with active systemic lupus erythematosus (SLE).

13 Nov 2007

Are there rearrangement hot spots in the human genome?

The debate over the validity of genomic rearrangement "hotspots" has its most recent addition in a new theory put forth by researchers at the University of California San Diego.

13 Nov 2007

Newly completed genome sequence may provide new treatment options for dandruff

Scientists from P&G Beauty announced that they successfully sequenced the complete genome for Malassezia globosa (M. globosa) , a naturally occurring fungus responsible for the onset of dandruff and other skin conditions in humans.

6 Nov 2007

Selective resequencing provides low-cost method for interpreting human genome

Cold Spring Harbor, NY Scientists at Cold Spring Harbor Laboratory (CSHL) have developed a new means of extracting and interpreting data from the human genome that is more powerful and more economical than methods currently employed.

6 Nov 2007

Sex ratio skew explained

If you met a person who had 10 children, all of whom were girls, you would probably find this surprising.

6 Nov 2007

New role for p53 gene in childhood cancer

Researchers have identified a new role for a cancer-prevention gene in the response to drug treatment for childhood cancer.

6 Nov 2007

FADS2 gene governs IQ boost from breastfeeding

The known association between breast feeding and slightly higher IQ in children has been shown to relate to a particular gene in the babies, according to a report this week in the Proceedings of the National Academy of Sciences.

6 Nov 2007

New view of lung cancer genome

An international team of scientists, supported in part by the National Human Genome Research Institute (NHGRI), one of the National Institutes of Health (NIH), have announced that its systematic effort to map the genomic changes underlying lung cancer has uncovered a critical gene alteration not previously linked to any form of cancer.

5 Nov 2007

Comprehensive view of the abnormal genetic landscape in lung cancer cells

An international team of scientists has announced the results of a systematic effort to map the genetic changes underlying lung cancer, the world's leading cause of cancer deaths.

5 Nov 2007

Inheriting two genetic mutations that can individually cause epilepsy may cancel each other

Inheriting two genetic mutations that can individually cause epilepsy might actually be "seizure-protective," said Baylor College of Medicine researchers in a report that appears online in the journal Nature Neuroscience.

5 Nov 2007

Discovery of gene variant linked to prostate cancer in African Americans

Researchers report a newly identified genetic variation that is linked to higher incidence of prostate cancer in African American men.

1 Nov 2007

Scientists to map lethal bacteria in three dimensions

A scientist slides on a pair of plastic 3-D glasses and an unearthly blue multi-armed creature -- an image right out of a sci-fi horror flick -- seems to leap out of the computer screen into the laboratory.

1 Nov 2007

New genetic variant associated with prostate cancer in African-Americans

Two tiny genetic variations may provide the best clues yet for finding more precise ways to estimate prostate cancer risk and improve screening and early detection for men of African descent, report researchers from the University of Chicago and the Translational Genomics Research Institute, Phoenix, AZ, in the December 2007 issue of Genome Research, published early online.

1 Nov 2007