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Immune checkpoint inhibitor therapy results in longer treatment-free survival for patients with advanced renal cell carcinoma

Patients with advanced renal cell carcinoma who received the checkpoint inhibitor combination nivolumab (Opdivo) plus ipilimumab (Yervoy) experienced longer treatment-free survival (TFS) over a 42-month period than patients who received the targeted therapy sunitinib (Sutent), regardless of the International Metastatic Renal Cell Carcinoma Database Consortium (IMDC) risk group, according to new analysis of the CheckMate-214 clinical trial.

10 Nov 2021

Researchers discover mechanisms underlying the unwanted side effects of drugs

Researchers at Weill Cornell Medicine have discovered how drugs can affect various membrane-spanning proteins in addition to their intended target, potentially causing unwanted side effects.

10 Nov 2021

UArizona researchers get closer to developing a safe, effective non-opioid pain reliever

Researchers at the University of Arizona Health Sciences are closer to developing a safe and effective non-opioid pain reliever after a study showed that a new compound they created reduces the sensation of pain by regulating a biological channel linked to pain.

10 Nov 2021

New method of stem cell transplantation may eliminate the need for radiation or chemotherapy

Studying mice, researchers at Washington University School of Medicine in St. Louis have developed a method of stem cell transplantation that does not require radiation or chemotherapy.

10 Nov 2021

Cancer drugs could be repurposed as potential therapies for Alzheimer's disease

Existing and emerging cancer drugs could be repurposed as therapies to be tested in clinical trials for people at genetic risk of Alzheimer's disease, according to a new study published in Science Advances.

10 Nov 2021

Coronaviruses synthesize RNA in membrane-bound compartments

A team of researchers show that IBV viral RNA synthesis occurs within the membrane-bound compartment

10 Nov 2021

The SARS-CoV-2 Beta variant evades Fc effector function by ancestral strain, study says

A new study finds improved Fc cross-reactivity against certain SARS-CoV-2 variant of concern.

10 Nov 2021

Stenoparib effectively inhibits SARS-CoV-2 variants in vitro

A new study assesses the antiviral activity of stenoparib against four SARS-CoV-2 strains.

10 Nov 2021

Identifying an important protein for motor coordination

News-Medical speaks to Professor Jorge Ruas about how he has identified an important protein involved in motor coordination.

10 Nov 2021

Chronological changes in SARS-CoV-2 immune responses after BNT162b2 vaccine

A new study focused on the chronological changes in humoral and cell-mediated immune responses, during and after the BNT162b2 vaccine administration, among hospital workers of a national medical institution in Japan.

10 Nov 2021

Cell-based viral replication system for screening of SARS-CoV-2 drugs

The current study reports a SARS-CoV-2 replicon system within stable cell lines that can be cultured with ease in a standard biosafety level 2 laboratory.

10 Nov 2021

Tiny particles of gold could help combat antibiotic resistance

Tiny particles of gold could be the new weapon in the fight against bacterial antibiotic resistance, according to research just published.

10 Nov 2021

Mechanism of SARS-CoV-2 antibody transfer into breastmilk

A recent study aimed to understand better the mechanism of antibody transfer to breastmilk in the setting of SARS-CoV-2 infection.

10 Nov 2021

Western boom cities see spike in harmful ozone

The reduction of harmful ground-level ozone across most of the U.S. over the past several decades has been an air pollution success story.

10 Nov 2021

Ion channel mechanosensor plays a key role in regulating the speed of skin wound healing

PIEZO1, an ion channel mechanosensor found within cells, has been revealed to play a key role in regulating the speed of skin wound healing by researchers at the University of California, Irvine.

10 Nov 2021

New epigenetic editing technique may advance the treatment of many diseases

Type 1 diabetes, rheumatoid arthritis, and cancer are just some of the disorders associated with specific genes not "turning on" and "turning off" as they should.

9 Nov 2021

Study: Most pediatric cancer patients have mild COVID-19 and make full recovery

Most children and adolescents with cancer have mild COVID-19 disease and make a full recovery, a new study has found. But pediatric cancer patients with underlying health conditions, severe infections and low white blood cell counts were significantly more likely to have severe disease.

9 Nov 2021

Retinoid therapy improves vision in mice with Usher syndrome

Using data generated from patients and mice with genetic mutation for the disorder Usher syndrome, researchers from the University of Maryland School of Medicine, the National Institutes of Health's National Eye Institute, and National Institute on Deafness and Other Communication Disorders, documented the natural history of vision impairment in patients and identified the cell mechanism behind progressive vision loss.

9 Nov 2021

Researchers investigate how intestinal bacteria distribute metabolic products in membrane vesicles

Bacteria in the intestine pack a wide spectrum of their biomolecules into small capsules. These are transported via the bloodstream to various organs in the body and even absorbed and processed by nerve cells in the brain.

9 Nov 2021

Proton therapy used for the first time in Switzerland to treat lung cancer

Today a 60-year-old patient suffering from lung cancer received proton beam therapy, a medical procedure where positively charged particles are precisely targeted at the tumor. This is the first time this type of radiotherapy has been used for lung cancer treatment in Switzerland.

9 Nov 2021