Clinical Trial News and Research

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New targeted therapy shows early success in treating pediatric high-grade gliomas

An international team of clinical collaborators, led by physician scientists from Dana-Farber Cancer Institute, performed a first-ever clinical test of the targeted therapy avapritinib in pediatric and young patients with a form of high-grade glioma.

20 Mar 2025

Experimental drug shows promise in reducing risk of Alzheimer's-related dementia

An experimental drug appears to reduce the risk of Alzheimer's-related dementia in people destined to develop the disease in their 30s, 40s or 50s, according to the results of a study led by the Knight Family Dominantly Inherited Alzheimer Network-Trials Unit (DIAN-TU), which is based at Washington University School of Medicine in St. Louis.

19 Mar 2025

Clinical trial investigates osteoporosis medication for type 1 diabetes

City of Hope®, one of the largest and most advanced cancer research and treatment organizations in the United States and a top research center for diabetes and other life-threatening illnesses, is leading a phase 1/2 clinical trial investigating an osteoporosis medication as a way to improve beta cell health in people with early type 1 diabetes.

19 Mar 2025

Electronic cigarettes may pose lower cardiovascular risks for people with HIV

Electronic cigarettes use may pose lower cardiovascular risks in people living with HIV compared to tobacco cigarette use, new UCLA-led research shows.

19 Mar 2025

Alzheimer's-modifying drug lecanemab's effectiveness may vary between genders

Since becoming only the second Alzheimer's-modifying drug to gain American Federal Drug Administration approval in 2023, sales of lecanemab, known by its brand name Leqembi, have risen steadily, reaching $87-million USD in the last quarter of 2024.

18 Mar 2025

Continuous glucose monitors show promise in managing diabetic ketoacidosis

Diabetic ketoacidosis is a common severe complication of diabetes, which develops when the body can't produce enough insulin.

18 Mar 2025

AI could play a key role in improving prostate cancer treatment outcomes

A study led by UCLA investigators shows that artificial intelligence (AI) could play a key role in improving treatment outcomes for men with prostate cancer by helping physicians determine who is most likely to benefit from partial gland cryoablation, a minimally invasive procedure that treats localized prostate tumors.

18 Mar 2025

Vegan diets aid weight loss, but cutting animal-based processed foods matters most

A vegan diet rich in low-fat plant-based foods can lead to significant weight loss, regardless of food processing levels, whereas reducing processed animal foods is strongly linked to lower body weight.

18 Mar 2025

WIN Consortium revolutionizing precision oncology for cancer patients

A new precision oncology paper was published in Oncotarget, Volume 16, on March 12, 2025, titled "Worldwide Innovative Network (WIN) Consortium in Personalized Cancer Medicine: Bringing next-generation precision oncology to patients."

18 Mar 2025

ASCOLT trial explores aspirin’s role in preventing colorectal cancer recurrence

A large-scale, international, multicentre, phase 3 clinical trial of aspirin for the secondary prevention of colorectal cancer has concluded.

17 Mar 2025

Baked eggs in infancy may lower lifelong egg allergy risk

Introducing baked eggs to infants aged 4–6 months and maintaining daily intake for six months significantly improves tolerance to cooked eggs, reducing the risk of egg allergy.

17 Mar 2025

Surgery reduces health care visits in children with mild sleep-disordered breathing

Surgical removal of enlarged tonsils and adenoids in children with mild sleep-disordered breathing (SDB) appears to significantly reduce the frequency of medical office visits and prescription medicine use in this group, according to a clinical study supported by the National Institutes of Health (NIH).

17 Mar 2025

Clinical trial of vaccine candidate to prevent Lassa fever begins enrollment

A National Institutes of Health (NIH)-sponsored clinical trial of a candidate vaccine to prevent Lassa fever has begun enrolling participants at the University of Maryland School of Medicine, Baltimore.

17 Mar 2025

Yale research supports MRD detection for post-treatment lung cancer care

In the continuing evolution of personalized medicine, a new Yale study has found evidence to support the value of a tool that measures the presence of cancer-derived molecules in the blood of patients with lung cancer years after their treatment.

17 Mar 2025

SolasCure enrols first patient in a next phase II clinical trial to advance Aurase Wound Gel

SOLASCURE Ltd (SolasCure), a biotechnology company developing a novel treatment to transform chronic wound healing, today announced the initiation of a new Phase II clinical trial, CLEANVLU2.

17 Mar 2025

Adding chemotherapy to radiotherapy does not improve outcomes for cervical cancer patients

Results from the NRG Oncology GOG-0263 phase III clinical trial testing the addition of cisplatin-based chemotherapy to adjuvant radiotherapy following radical hysterectomy and lymphadenectomy for patients with early-stage, intermediate-risk cervical carcinoma indicated that the addition of chemotherapy did not improve outcomes for patients and led to increased toxicity for patients.

14 Mar 2025

Blood-brain barrier dysfunction and inflammation linked to Down syndrome Regression Disorder

A new research study led by Jonathan D. Santoro, MD, Director of the Neuroimmunology Program at Children's Hospital Los Angeles, shows evidence of dysfunction of the blood-brain barrier and inflammation in the central nervous system in individuals with Down syndrome Regression Disorder (DSRD).

14 Mar 2025

Combination of RAS inhibition and immunotherapy provides breakthrough for pancreatic cancer

Adding immunotherapy to a new type of inhibitor that targets multiple forms of the cancer-causing gene mutation KRAS kept pancreatic cancer at bay in preclinical models for significantly longer than the same targeted therapy by itself, according to researchers from the Perelman School of Medicine at the University of Pennsylvania and Penn Medicine's Abramson Cancer Center.

14 Mar 2025

New therapeutic approach shows promise for pediatric high-grade gliomas

Brain tumors remain the most common cause of death from childhood cancer. Paediatric high-grade gliomas (pHGG) in particular are a mostly fatal disease group with a median survival time of less than 18 months after diagnosis and limited treatment options.

14 Mar 2025

Modified tool helps assess symptoms in cognitively impaired nursing home residents

As many as half of nursing home residents are cognitively impaired and may be unable to communicate symptoms such as pain or anxiety to the staff and clinicians caring for them.

14 Mar 2025

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Clinical Trial News and Research

New targeted therapy shows early success in treating pediatric high-grade gliomas

Experimental drug shows promise in reducing risk of Alzheimer's-related dementia

Clinical trial investigates osteoporosis medication for type 1 diabetes

Electronic cigarettes may pose lower cardiovascular risks for people with HIV

Alzheimer's-modifying drug lecanemab's effectiveness may vary between genders

Continuous glucose monitors show promise in managing diabetic ketoacidosis

AI could play a key role in improving prostate cancer treatment outcomes

Vegan diets aid weight loss, but cutting animal-based processed foods matters most

WIN Consortium revolutionizing precision oncology for cancer patients

ASCOLT trial explores aspirin’s role in preventing colorectal cancer recurrence

Baked eggs in infancy may lower lifelong egg allergy risk

Surgery reduces health care visits in children with mild sleep-disordered breathing

Clinical trial of vaccine candidate to prevent Lassa fever begins enrollment

Yale research supports MRD detection for post-treatment lung cancer care

SolasCure enrols first patient in a next phase II clinical trial to advance Aurase Wound Gel

Adding chemotherapy to radiotherapy does not improve outcomes for cervical cancer patients

Blood-brain barrier dysfunction and inflammation linked to Down syndrome Regression Disorder

Combination of RAS inhibition and immunotherapy provides breakthrough for pancreatic cancer

New therapeutic approach shows promise for pediatric high-grade gliomas

Modified tool helps assess symptoms in cognitively impaired nursing home residents

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