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Lab experiments add further evidence to the bradykinin storm theory of COVID-19’s viral pathogenesis

A new paper published in Nature Communications adds further evidence to the bradykinin storm theory of COVID-19's viral pathogenesis - a theory that was posited two years ago by a team of researchers at the Department of Energy's Oak Ridge National Laboratory.

16 Sep 2022

New dental coating replicates the composition and microstructure of natural enamel

Scientists have perfected hydroxyapatite, a material for mineralizing bones and teeth. By adding a complex of amino acids to hydroxyapatite, they were able to form a dental coating that replicates the composition and microstructure of natural enamel.

16 Sep 2022

Exercise hormone irisin blocks Parkinson's-associated α-synuclein aggregation and related neuronal toxicity

A new paper discusses the hope held out by recent results on a compound called irisin, a short protein secreted by skeletal muscle that produces some exercise-related effects on the brain.

15 Sep 2022

Experimental drug prolongs survival, improves muscle function in mice severe Duchenne muscular dystrophy

Researchers at Johns Hopkins Medicine report that an experimental drug first developed to treat kidney disease prolongs survival and improves muscle function in mice genetically engineered to develop a severe form of Duchenne muscular dystrophy (DMD).

13 Sep 2022

New drug induces similar effects as exercise to aid in the treatment of locomotor frailty

Maintaining a regular workout routine can help you look and feel great – but did you know that exercise also helps maintain your muscles and bones? People who are unable to engage in physical activity experience weakening of the muscles and bones, a condition known as locomotor frailty.

13 Sep 2022

Are pesticides affecting childhood growth in low-income countries?

Researchers assess the risk posed by these chemicals to the developing fetus and child.

12 Sep 2022

The use of AlphaFold2-enabled molecular docking simulations to predict protein-ligand interactions for antibiotic drug discovery

Researchers demonstrated that advances in modeling protein-ligand interactions using machine learning-based approaches are needed to exploit AlphaFold2 for antibiotic discovery better.

9 Sep 2022

NIH animal study combines Paxlovid with Lagevrio against SARS-CoV-2 Delta

In a recent study posted to the bioRxiv* preprint server, researchers at the U.S National Institutes of Health demonstrated the efficacy of molnupiravir and nirmatrelvir, two oral severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antivirals in the rhesus macaque model, the closest proxy to humans.

7 Sep 2022

Photocatalyst-based ViraMap platform maps SARS-CoV-2 spike protein interactions on the cell surface

Researchers performed the photocatalytic mapping of the SARS-CoV-2 spike protein-host cell membrane interactions.

7 Sep 2022

Auranofin inhibits SARS-CoV-2 replication

In a new ISCIENCE journal study, scientists identified an FDA-approved NF-κB inhibitor, Auranofin, which can also control inflammation.

6 Sep 2022

Exposure to blue light may accelerate aging

A new study provides insights into the novel mechanisms through which blue light exposure interferes with non-retinal cell metabolic pathways in flies.

5 Sep 2022

New substance boosts the effect of protein-based COVID-19 vaccines

Ironically, some vaccines need their own "boosters." Adding an ingredient called an adjuvant can help vaccines elicit a more robust immune response, better training the body to fight a pathogen.

1 Sep 2022

Rutgers scientists design a synthetic protein that quickly detects molecules of deadly nerve agent

A team that includes Rutgers scientists has designed a synthetic protein that quickly detects molecules of a deadly nerve agent that has been classified by the United Nations as a weapon of mass destruction and could be used in a chemical warfare attack.

1 Sep 2022

Compound News and Research

Lab experiments add further evidence to the bradykinin storm theory of COVID-19’s viral pathogenesis

New dental coating replicates the composition and microstructure of natural enamel

Exercise hormone irisin blocks Parkinson's-associated α-synuclein aggregation and related neuronal toxicity

Experimental drug prolongs survival, improves muscle function in mice severe Duchenne muscular dystrophy

New drug induces similar effects as exercise to aid in the treatment of locomotor frailty

Are pesticides affecting childhood growth in low-income countries?

The use of AlphaFold2-enabled molecular docking simulations to predict protein-ligand interactions for antibiotic drug discovery

NIH animal study combines Paxlovid with Lagevrio against SARS-CoV-2 Delta

Photocatalyst-based ViraMap platform maps SARS-CoV-2 spike protein interactions on the cell surface

Auranofin inhibits SARS-CoV-2 replication

Exposure to blue light may accelerate aging

New substance boosts the effect of protein-based COVID-19 vaccines

Rutgers scientists design a synthetic protein that quickly detects molecules of deadly nerve agent

Less is more: early short-course rapamycin effective in sustained anti-aging effects

Naturally occurring compound possesses antibacterial activity against several microorganisms

Using AI to foster productivity in pharmaceutical research and development

The risk of adverse reactions when herbal medications are taken with cancer drugs

Congressman’s wife died after taking herbal remedy marketed for diabetes and weight loss

New preclinical drug candidate shows promise in eradicating gonorrhea bacteria

“Drug factory” implants show promise in eradicating mesothelioma tumors

Advancing therapeutic biopolymer development eBook

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

Bringing real-time analytics to downstream bioprocess monitoring

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