Endoplasmic reticulum (ER) News and Research

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Breast cancer incidence continues to trend low in 2004

An extended analysis of cancer rates reinforces a strong association between use of hormone replacement therapy (HRT) and increased breast cancer incidence, according to research led by scientists at The University of Texas M. D. Anderson Cancer Center and published in the New England Journal of Medicine.

19 Apr 2007

Drop in HRT use linked to decrease in breast cancer rates

According to the latest report the drop in the use of hormone replacement therapy (HRT) in mid-2002, following the results of the Women's Health Initiative study (WHI), is linked with a steep decline in new breast cancer diagnoses.

19 Apr 2007

New findings on salicylates may lead to more effective aspirin-like drugs

Salicylates, including aspirin, are used to treat a range of inflammatory conditions and can be used to prevent diseases such as cancer, but the way aspirin works is not yet fully understood.

7 Apr 2007

Although breast cancer mortality has declined as a whole, declines are greatest for women under 70

A new study shows that recent declines in breast cancer mortality rates have been most significant among women with estrogen receptor (ER)-positive tumors and women younger than 70.

4 Apr 2007

Chemotherapy and tamoxifen combination improves survival for early-stage breast cancer patients

Patients with early-stage breast cancer who are treated with both chemotherapy and tamoxifen have a higher survival rate than patients who receive only tamoxifen.

3 Apr 2007

Triple negative breast cancers more common among women who are African American and Hispanic, under 40 years old

So-called "triple negative" breast cancers, tumors that do not contain any of three significant tumor markers, are aggressive, deadly cancers that affect young, poor minority women, according to a new study.

2 Apr 2007

New system to speed critical care to acute heart attack patients

Mayo Clinic has designed a new system to speed critical care to acute heart attack patients that dramatically reduces the time that elapses before patients undergo a life-saving procedure -- by as much as 45 percent in some cases.

2 Apr 2007

Penwest confirms action on Oxymorphone patent application

Penwest Pharmaceuticals has confirmed that the U.S. Patent and Trademark Office (PTO) has posted on its website an indication that a final rejection of Penwest's patent application claiming the sustained release formulations of Oxymorphone will be mailed.

15 Mar 2007

New method for identifying viruses and bacteria that cause common infections in children

Infectious disease specialists at UT Southwestern Medical Center have found a new method for identifying suspect viruses and bacteria that cause some of the most common acute infections in children.

13 Mar 2007

Tamoxifen offers long-term benefits for breast cancer prevention among women at high risk

The trials found that the breast cancer risk reduction persists long after women stop taking tamoxifen.

20 Feb 2007

Researchers discover markers that identify breast cancer subtypes resistant to Herceptin

Using gene chips to profile tumors before treatment, researchers at Harvard and Yale Universities found markers that identified breast cancer subtypes resistant to Herceptin, the primary treatment for HER2-positive breast cancer. They say this advance could help further refine therapy for the 25 to 30 percent of breast cancer patients with this class of tumor.

20 Feb 2007

700,000 adverse drug events in the U.S. each year lead to ER visits

Each year, an estimated 700,000 persons experience adverse drug events that lead to emergency department visits, according to a study in the October 18 issue of JAMA: The Journal of the American Medical Association.

17 Oct 2006

New avenue for the pursuit of therapies for Alzheimer's disease

The genes responsible for an inherited form of Alzheimer's disease play a direct role within cells that has largely been overlooked, according to a report in the September 8, 2006 issue of the journal Cell.

7 Sep 2006

GenoMed's West Nile virus trial endorsed by expert

GenoMed has announced the endorsement of its trial for West Nile virus encephalitis by an authority in Emergency Medicine, Dr. Neal Handly.

8 Aug 2006

Gleevec may cause heart problems

Gleevec, the wildly successful poster-child of a new generation of cancer drugs aimed at specific targets in the cancer cell, can be dangerous to the heart.

24 Jul 2006

FoxM1 regulates the expression of oestrogen receptors in breast cancer

Research just published online in the "Journal of Biological Chemistry" identifies a new molecule involved in the regulation of oestrogen receptors (ER) expression in breast cancer.

12 Jul 2006

Scientists identify overactive protein that plays a key role in cystic fibrosis

A team led by Johns Hopkins Children's Center scientists has identified and successfully tamed an overactive protein that plays a key role in cystic fibrosis (CF), a genetic disorder that interferes with the body's ability to transport chloride in and out of cells.

5 Jul 2006