Mouse Model News and Research

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Intervention during the first five weeks of life prevents autism symptoms from ever developing in mice

Timing is key when treating developmental disorders. Blocking an overactive signaling pathway during the first five weeks of life prevents autism symptoms from ever developing in mice, according to new research published in JNeurosci.

21 Feb 2022

Study suggests non-classical inhibition of TBK1/IKKε is protective against severe COVID-19 immunopathology in vivo

A study posted suggested the inhibition of TBK1 and its homolog KKε could decrease the severity of COVID-19.

21 Feb 2022

Inhalable antibody fragments offer broad protection from SARS-CoV-2 variants

A new study describes a potential new approach to treating COVID-19 in the form of single-chain fragment variable (scFv) antibodies.

20 Feb 2022

Study identifies a protein complex critical for regulating apoptosis and necroptosis

Cell death plays an important role in normal human development and health but requires tightly orchestrated balance to avert disease. Too much can trigger a massive inflammatory immune response that damages tissues and organs. Not enough can interfere with the body's ability to fight infection or lead to cancer.

18 Feb 2022

New insights into why women develop Alzheimer's symptoms earlier and exhibit faster memory decline

A joint study by Nanyang Technological University, Singapore and National University of Singapore (NUS) scientists has examined why, in mice, female brains are more predisposed to Alzheimer's disease and other neurodegenerative diseases.

16 Feb 2022

The in vitro selection of a remdesivir-resistant SARS-CoV-2 mutation

Researchers select and study an RDV-resistant virus by serial passaging of wild type SARS-CoV-2 in the presence of increasing concentrations of RDV.

15 Feb 2022

Novel promising biomarker correlates with the severity of facioscapulohumeral muscular dystrophy

There is currently no effective treatment for facioscapulohumeral muscular dystrophy (FSHD), one of the most common neuromuscular diseases, which is caused by an abnormal expression of the transcription factor DUX4.

15 Feb 2022

Researchers find potential new strategy to treat metastatic form of intra-abdominal cancer

Researchers from the National Cancer Centre Singapore (NCCS) have found a potential new strategy to treat peritoneal carcinomatosis, a metastatic form of intra-abdominal cancer, where patients are presented with limited treatment options and poor overall survival.

15 Feb 2022

UCI biologists discover how a protective mutation may reduce Alzheimer's risk

While the word "mutation" may conjure up alarming notions, a mutation in brain immune cells serves a positive role in protecting people against Alzheimer's disease.

14 Feb 2022

Surprising discovery about genetic form of microcephaly has potential to inform treatment strategies

Virginia Tech researchers publishing in the Journal of Medical Genetics made a discovery about a genetic form of microcephaly -- a condition where babies' heads and brains are smaller and grow more slowly than those of unaffected children.

14 Feb 2022

Researchers identify a powerful combination of antivirals to treat COVID-19

Researchers at the University of Maryland School of Medicine and University of Pennsylvania Perelman School of Medicine have identified a powerful combination of antivirals to treat COVID-19.

14 Feb 2022

mRNA-1273 and mRNA-1273.529 Omicron-specific boosters highly effective in mouse model

In a study posted to the bioRxiv* preprint server, a team of researchers from the United States evaluated the protective effect of the preclinical version of the current Moderna Omicron-targeted mRNA-1273.529 vaccine against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) B.1.1.529 Omicron infection in mice.

14 Feb 2022

New protocol for transplanting 3D cellular structures to regenerate damaged intestinal tissue

Ulcerative colitis is an inflammatory bowel disease (IBD) that causes inflammation and ulcers (sores) in the digestive tract. Ulcerative colitis affects the innermost lining of the colon and rectum.

10 Feb 2022

Researchers identify a potent new combination of antiviral drugs to combat SARS-CoV-2

The recent success of Paxlovid has encouraged researchers to develop new anti-covid drugs. With this in mind, scientists from the University of Pennsylvania have been investigating a new synergistic treatment. Their research is released early as an unedited version of the manuscript to be published in the journal Nature.

9 Feb 2022

30-year-old cancer drug could get another shot, study says

A study by Virginia Commonwealth University Massey Cancer Center researchers published in today's print edition of Molecular Cancer Therapeutics shows that triplatin is effective against triple negative breast cancer, which is the most aggressive form of breast cancer and has few targeted therapies.

9 Feb 2022

Old FDA-approved drug may protect against lung injury and blood clots in severe COVID-19

An FDA-approved drug that has been in clinical use for more than 70 years may protect against lung injury and the risk of blood clots in severe COVID-19 and other disorders that cause immune-mediated damage to the lungs, according to a preclinical study from researchers at Weill Cornell Medicine and Cold Spring Harbor Laboratory.

8 Feb 2022

Researchers identify a bivalent histone-mark switch essential for angiogenesis

Defying conventional epigenomic wisdom, the non-conventional polycomb (PRC)1 variant paradoxically overwhelms the conventional PRC-mediated gene silencing in activated endothelial cells.

8 Feb 2022

Efficacy of MVA-CoV2-S vaccination to prevent SARS-CoV-2 cerebral infection and associated damage

Researchers demonstrated that an MVA vector expressing the SARS-CoV-2 spike protein was 100% effective in preventing neuroinvasion and brain damage by SARS-CoV-2 in transgenic mice.

8 Feb 2022

Maternal metabolic syndrome can switch on imprinted gene associated with NAFLD in offspring

New research from North Carolina State University has found that an imprinted gene associated with development of non-alcoholic fatty liver disease (NAFLD) is switched on in mice who nurse from mothers with metabolic syndrome, even when those mice are not biologically related.

7 Feb 2022

UCLA researchers develop first human genomic transgenic mouse model of Huntington's disease

Researchers at the Jane and Terry Semel Institute for Neuroscience and Human Behavior at UCLA and the David Geffen School of Medicine at UCLA have developed a new mouse model of Huntington's disease that recapitulates more Huntington's disease-like characteristics than earlier models.

2 Feb 2022

Mouse Model News and Research

Intervention during the first five weeks of life prevents autism symptoms from ever developing in mice

Study suggests non-classical inhibition of TBK1/IKKε is protective against severe COVID-19 immunopathology in vivo

Inhalable antibody fragments offer broad protection from SARS-CoV-2 variants

Study identifies a protein complex critical for regulating apoptosis and necroptosis

New insights into why women develop Alzheimer's symptoms earlier and exhibit faster memory decline

The in vitro selection of a remdesivir-resistant SARS-CoV-2 mutation

Novel promising biomarker correlates with the severity of facioscapulohumeral muscular dystrophy

Researchers find potential new strategy to treat metastatic form of intra-abdominal cancer

UCI biologists discover how a protective mutation may reduce Alzheimer's risk

Surprising discovery about genetic form of microcephaly has potential to inform treatment strategies

Researchers identify a powerful combination of antivirals to treat COVID-19

mRNA-1273 and mRNA-1273.529 Omicron-specific boosters highly effective in mouse model

New protocol for transplanting 3D cellular structures to regenerate damaged intestinal tissue

Researchers identify a potent new combination of antiviral drugs to combat SARS-CoV-2

30-year-old cancer drug could get another shot, study says

Old FDA-approved drug may protect against lung injury and blood clots in severe COVID-19

Researchers identify a bivalent histone-mark switch essential for angiogenesis

Efficacy of MVA-CoV2-S vaccination to prevent SARS-CoV-2 cerebral infection and associated damage

Maternal metabolic syndrome can switch on imprinted gene associated with NAFLD in offspring

UCLA researchers develop first human genomic transgenic mouse model of Huntington's disease

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