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UCL researchers boost the effectiveness of therapeutic vaccine for chronic HBV

Scientists at UCL have significantly boosted the effectiveness of a therapeutic vaccine designed to control chronic hepatitis B (HBV) infection, after uncovering and thwarting 'the enemy within'.

13 Apr 2022

Gut microbes play a key role in regulating pancreas function, size and hormone secretion

Gut microbes can regulate the exocrine and endocrine functions of the pancreas and hormone production of the gastrointestinal tract, findings that may help develop potential treatments for diabetes and other diseases, a team of researchers from Boston College, Joslin Diabetes Center, and Maastricht University, Netherlands, report in the journal Diabetes.

13 Apr 2022

Researchers identify certain gene regulation signatures in CAR T-resistant leukemia patients

Acute lymphoblastic leukemia (ALL) cells from patients whose cancers did not respond to CD19-targeted CAR T therapy had gene regulation signatures that could potentially facilitate treatment resistance, according to results presented at the AACR Annual Meeting 2022, held April 8-13.

13 Apr 2022

Researchers make progress to develop a drug for treating metabolic syndrome

Metabolic syndrome increases a person's risk for diabetes, heart disease, and stroke, and includes conditions such as obesity, high blood pressure and high blood sugar.

11 Apr 2022

Yale researchers discover immune response pathway that leads to severe COVID-19

Yale researchers have identified a particular immune response pathway that leads to severe illness and death in people infected by the SARS-CoV-2 virus.

7 Apr 2022

Mutant mice with a human gene variant exhibits ADHD-like problems

Mutant mice are providing scientists with a new neurobiological framework to understand the brain changes observed in distractible humans who carry a common gene variant whose frequency has been associated with Attention Deficit Hyperactivity Disorder (ADHD).

7 Apr 2022

Modified version of hormone kisspeptin can be used to treat non-alcoholic fatty liver disease

A hormone that triggers puberty and controls fertility in humans might be developed as a treatment for non-alcoholic fatty liver disease, according to new Rutgers research.

7 Apr 2022

Insights into the pathogenesis of the previous and circulating SARS-CoV-2 variants in mice

A recent article presented the diverse pathogenesis of SARS-CoV-2 variants of concern in a humanized mouse model.

7 Apr 2022

Animal study provides insights into how COVID-19 can lead to long-term pain

A new animal study has provided important insights into how COVID-19 SARS-CoV-2 - the virus responsible for COVID-19 - can lead to long-term pain.

4 Apr 2022

Study reveals how zinc supports immunity, suggests ways it could be used to improve health

Zinc's immune-boosting properties are well-established, but scientists haven't known exactly how it works.

1 Apr 2022

Mosaic-8 RBD-nanoparticles show promise as a vaccine candidate for SARS-CoV-2 and potential sarbecoviruses spillovers

Researchers designed nanoparticles representing RBDs of the S protein of animal sarbecoviruses and SARS-CoV-2 to evaluate their potential as a pan-sarbecovirus vaccine candidate.

31 Mar 2022

Researchers create method to track SARS-CoV-2 RBD binding in vivo

Researchers developed a method for tracking the binding of the receptor-binding domain of SARS-CoV-2 in vivo using genetically engineered extracellular vesicles that can migrate to ACE2 expressing cells.

30 Mar 2022

Divalent SARS-CoV-2 fusion vaccine found to be effective in mice

Researchers bioengineered a divalent fusion vaccine by combining the immunogenic region of the nucleocapsid protein and the receptor-binding domain of the spike protein of SARS-CoV-2.

30 Mar 2022

Researchers present a possible therapeutic approach for severe congenital myopathy

The diagnosis is rare, but devastating – children with congenital muscle disorders often never learn to walk. Until now, there was no chance of recovery, but researchers at the University of Basel and University Hospital Basel are now presenting a possible therapeutic approach for the first time.

29 Mar 2022

Potential new therapeutic target for pancreatic cancer discovered

Northwestern Medicine investigators have discovered that targeting the G alpha 13 protein in pancreatic tumors promotes tumor growth and progression, according to a study published in Cell Reports.

29 Mar 2022

Magneto-activated natural killer cells for treating solid tumors

Cancer immunotherapy - a type of treatment that enlists our own immune cells to attack tumors - has revolutionized the way that many types of cancer are treated. One type of immunotherapy under investigation uses natural killer cells, a type of immune cell that can seek and destroy harmful cells.

28 Mar 2022

Topologically designed antibody candidates for SARS-CoV-2 and cancer therapies

A recent study presented topologically engineered fragment crystallizable-fusion proteins and antibodies as therapeutic options for diseases like human coronaviruses infections and cancers.

25 Mar 2022

Niacin limits Alzheimer's disease progression in animal model

Indiana University School of Medicine researchers found that niacin limits Alzheimer's disease progression when used in models in the lab, a discovery that could potentially pave the way toward therapeutic approaches to the disease.

23 Mar 2022

Scientists develop first drug to treat uncontrolled secretion of mucins in the airways

A multicenter research team co-led by The University of Texas MD Anderson Cancer Center developed the first drug to treat the uncontrolled secretion of mucins in the airways, which causes potentially life-threatening symptoms in millions of Americans with asthma, chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF), as well as lung disease resulting from cancer and cancer treatment.

23 Mar 2022

UI neuroscientists identify fundamental biochemical mechanism underlying memory storage

A University of Iowa neuroscience research team has identified a fundamental biochemical mechanism underlying memory storage and has linked this mechanism to cognitive deficits in mouse models of Alzheimer's Disease and Related Dementias.

23 Mar 2022

Mouse Model News and Research

UCL researchers boost the effectiveness of therapeutic vaccine for chronic HBV

Gut microbes play a key role in regulating pancreas function, size and hormone secretion

Researchers identify certain gene regulation signatures in CAR T-resistant leukemia patients

Researchers make progress to develop a drug for treating metabolic syndrome

Yale researchers discover immune response pathway that leads to severe COVID-19

Mutant mice with a human gene variant exhibits ADHD-like problems

Modified version of hormone kisspeptin can be used to treat non-alcoholic fatty liver disease

Insights into the pathogenesis of the previous and circulating SARS-CoV-2 variants in mice

Animal study provides insights into how COVID-19 can lead to long-term pain

Study reveals how zinc supports immunity, suggests ways it could be used to improve health

Mosaic-8 RBD-nanoparticles show promise as a vaccine candidate for SARS-CoV-2 and potential sarbecoviruses spillovers

Researchers create method to track SARS-CoV-2 RBD binding in vivo

Divalent SARS-CoV-2 fusion vaccine found to be effective in mice

Researchers present a possible therapeutic approach for severe congenital myopathy

Potential new therapeutic target for pancreatic cancer discovered

Magneto-activated natural killer cells for treating solid tumors

Topologically designed antibody candidates for SARS-CoV-2 and cancer therapies

Niacin limits Alzheimer's disease progression in animal model

Scientists develop first drug to treat uncontrolled secretion of mucins in the airways

UI neuroscientists identify fundamental biochemical mechanism underlying memory storage

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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