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Researchers working to find faster way to treat sleeping sickness using oral drugs

Researchers at the University of Georgia are working to find the fastest way possible to treat and cure human African trypanosomiasis, long referred to as sleeping sickness. By working to improve chemical entities already tested in human clinical trials, they hope to have a faster route to field studies to treat the disease using drugs that can be administered orally to patients.

30 Aug 2016

Novel compound provides safe, effective pain relief with zero abuse potential in animal model

Since the isolation of morphine from opium in the 19th century, scientists have hoped to find a potent opioid analgesic that isn't addictive and doesn't cause respiratory arrest with increased doses.

30 Aug 2016

New orthotopic model recapitulates more closely metastatic steps in Ewing sarcoma

The Sarcoma research group of Bellvitge Biomedical Research Institute, led by Dr. Òscar Martínez-Tirado, has developed a modified version of an orthotopic model that allows researchers to recreate more closely the metastatic steps in Ewing sarcoma (ES), the second most common bone tumor in children and adolescents.

30 Aug 2016

Fluid-filled sacs that brain cells make to trap amyloid may contribute to Alzheimer's disease

Vesicles, fluid-filled sacs that brain cells make to trap amyloid, a hallmark of Alzheimer's, appear to also contribute to the disease, scientists report.

29 Aug 2016

Stiff arteries can negatively impact memory and vital brain processes

As we age, our arteries gradually become less flexible, making it harder for the heart to pump blood throughout the body.

26 Aug 2016

Researchers develop new method to culture norovirus in intestinal cells

Researchers have succeeded in culturing norovirus in human intestinal cells, a breakthrough that could help scientists develop novel therapeutics and vaccines against the debilitating effects of the virus.

26 Aug 2016

Study suggests structural changes in the brain help cope with stressful situations

People who experience job loss, divorce, death of a loved one or any number of life's upheavals often adopt coping mechanisms to make the situation less traumatic.

25 Aug 2016

Scientists move a step closer to translating BubR1 protein's function into potential cancer therapy

In a paper published recently in the journal eLife, Mayo Clinic scientists take a step toward translating the protein BubR1's function into a potential therapy for cancer.

24 Aug 2016

Study finds link between childhood manganese exposure and attentional dysfunction in rodent model

Researchers using a rodent model of childhood manganese exposure have found that too much manganese early in development causes lasting attention deficits and other impairments.

23 Aug 2016

Researchers find potential way to reduce effects of TBI with neuron-targeting nanoparticle

A fall down the stairs, a car crash, a sports injury or an explosive blast can all cause traumatic brain injury (TBI).

17 Aug 2016

Could nanotechnology turn the cancer cell suicide switch back on? An interview with Professor Dipanjan Pan

Before I explain the discovery, I would take a step back and explain an interesting event that takes place in the cancer cells. Normal cells follow a rapid and irreversible process to efficiently eradicate dysfunctional cells. This is a natural process by which damaged cells commit ‘suicide’. This process is known as apoptosis or programmed cell death.

15 Aug 2016

Noninvasive approach using pulsed electric fields may reduce scarring after burn injuries

A Massachusetts General Hospital research team has reported that repeated treatment with pulsed electric fields - a noninvasive procedure that does not generate heat - may help reduce the development of scarring.

10 Aug 2016

Wiley's Zika page offers free access to published content to coincide with events in Brazil

Wiley has made available all of its published Zika content on one site http://www.wiley.com/go/zika to coincide with events in Brazil, a territory that has seen increased cases of Zika Virus recently.

5 Aug 2016

Three vaccine candidates provide complete protection against Zika virus in rhesus monkeys

A month after announcing that two promising vaccine candidates provided mice with complete protection against the Zika virus, a research team at Beth Israel Deaconess Medical Center, in collaboration with scientists at Walter Reed Army Institute of Research and the University of São Paulo, now reports achieving complete protection against Zika virus in rhesus monkeys.

5 Aug 2016

Scientists use animal model to gain better understanding of cocaine addiction

Scientists at Wake Forest Baptist Medical Center are one step closer to understanding what causes cocaine to be so addictive. The research findings are published in the current issue of the Journal of Neuroscience.

2 Aug 2016

Study verifies human gene therapy in MPS I animal model

Researchers are closer to finding a better way to treat children with a rare metabolic disorder called MPS I. It is caused by a deficiency of the key enzyme IDUA needed to break down complex sugars in cells.

29 Jul 2016

UAB researchers uncover vital mechanism for L-DOPA-induced-dyskinesia

Though the drug levodopa can dramatically improve Parkinson's disease symptoms, within five years one-half of the patients using L-DOPA develop an irreversible condition -- involuntary repetitive, rapid and jerky movements.

29 Jul 2016

Waterloo researchers unveil new screening tool and data at 2016 AAIC

Two studies involving University of Waterloo researchers presented this week at the 2016 Alzheimer's Association International Conference (AAIC) in Toronto highlight a new diagnostic tool that can identify Alzheimer's disease long before the onset of symptoms as well as the increasing prevalence of Alzheimer's disease in Ontario.

27 Jul 2016

Penn researchers use iron-containing nanoparticles to reduce plaque and prevent tooth decay

The bacteria that live in dental plaque and contribute to tooth decay often resist traditional antimicrobial treatment, as they can "hide" within a sticky biofilm matrix, a glue-like polymer scaffold.

26 Jul 2016

Combination of two plant compounds holds promise in treating colon cancer

The combination of two plant compounds that have medicinal properties - curcumin and silymarin - holds promise in treating colon cancer, according Saint Louis University research published in the June 23 issue of the Journal of Cancer.

22 Jul 2016

Animal Model News and Research

Researchers working to find faster way to treat sleeping sickness using oral drugs

Novel compound provides safe, effective pain relief with zero abuse potential in animal model

New orthotopic model recapitulates more closely metastatic steps in Ewing sarcoma

Fluid-filled sacs that brain cells make to trap amyloid may contribute to Alzheimer's disease

Stiff arteries can negatively impact memory and vital brain processes

Researchers develop new method to culture norovirus in intestinal cells

Study suggests structural changes in the brain help cope with stressful situations

Scientists move a step closer to translating BubR1 protein's function into potential cancer therapy

Study finds link between childhood manganese exposure and attentional dysfunction in rodent model

Researchers find potential way to reduce effects of TBI with neuron-targeting nanoparticle

Could nanotechnology turn the cancer cell suicide switch back on? An interview with Professor Dipanjan Pan

Noninvasive approach using pulsed electric fields may reduce scarring after burn injuries

Wiley's Zika page offers free access to published content to coincide with events in Brazil

Three vaccine candidates provide complete protection against Zika virus in rhesus monkeys

Scientists use animal model to gain better understanding of cocaine addiction

Study verifies human gene therapy in MPS I animal model

UAB researchers uncover vital mechanism for L-DOPA-induced-dyskinesia

Waterloo researchers unveil new screening tool and data at 2016 AAIC

Penn researchers use iron-containing nanoparticles to reduce plaque and prevent tooth decay

Combination of two plant compounds holds promise in treating colon cancer

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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