Endoplasmic reticulum (ER) News and Research

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Association between Pak1 expression and subcellular localization and tamoxifen resistance in breast cancer patients

A protein that activates estrogen receptors in breast cancer may play a role in resistance to therapeutic effects of anti-estrogen tamoxifen treatment, according to a study in the Journal of the National Cancer Institute.

17 May 2006

Effectiveness of radiation therapy for older women with early breast cancer

Elderly women with early-stage breast cancer had a lower risk of recurrence when they were treated with radiation therapy, according to a study in the Journal of the National Cancer Institute.

17 May 2006

Caspase-12 antagonists could potentially be useful in the treatment of sepsis and other inflammatory and immune disorders

According to the new study, the presence of caspase-12, which appears to modulate inflammation and innate immunity in humans, increases the body's "vulnerability to bacterial infection and septic shock" while a deficiency confers strong resistance to sepsis. This new discovery suggests that caspase-12 antagonists could be a potentially useful in the treatment of sepsis and other inflammatory and immune disorders.

26 Apr 2006

Advances in chemotherapy significantly reduce risk of disease recurrence in breast cancer patients

Recent advances in chemotherapy have significantly reduced the risk of disease recurrence and death in breast cancer patients whose tumors are not hormone sensitive, according to a study by researchers at Dana-Farber Cancer Institute and 10 other institutions.

13 Apr 2006

Cardiocerebral resuscitation improves survival of patients with out-of-hospital cardiac arrest

Survival rates following the most common form of cardiac arrest increased three-fold when emergency medical personnel used a new form of CPR developed at The University of Arizona Sarver Heart Center.

13 Apr 2006

Essential information - how to deal with a serious allergic reaction

Hundreds of Americans die each year from anaphylaxis which is a serious allergic reaction that is rapid in onset and may cause death.

7 Mar 2006

Research highlights importance of detecting anthrax early

When spores sent through the mail in 2001 caused 11 people to contract anthrax - ultimately killing five of them - infectious disease specialists noted that the death rate was substantially lower than the historical mortality rate, which approached 100 percent.

24 Feb 2006

New mechanism that regulates K-Ras - protein that plays an important role in cancer

Researchers have discovered a protein widely known to cause the out-of-control growth of cells can actually be manipulated to induce those cells to commit suicide, providing a novel target for the development of anti-cancer drugs, according to the results of a new study led by New York University School of Medicine researchers.

21 Feb 2006

Researchers show how estrogen turns genes on and off during cancer progression

Ohio - A new study suggests that the hormone estrogen works in partnership with other proteins to activate or suppress gene activity in breast cancer cells.

2 Feb 2006

Cellular and molecular mechanisms that accelerate the development and progression of atherosclerosis

A McMaster University study on atherosclerosis will be featured on the cover of the December issue of the high impact American Heart Association scientific journal, Arteriosclerosis, Thrombosis and Vascular Biology.

2 Dec 2005

Survival benefits of longer-term tamoxifen use may take years to appear

The survival benefits of longer-term therapy using tamoxifen may take at least nine years to develop, according to a new study published in the December 1, 2005 issue of Cancer, a peer-reviewed journal of the American Cancer Society.

24 Oct 2005

Cell phones speed heart attack treatment

A Michigan hospital has cut in half the time it takes to begin life-saving treatment of heart attack patients by using cell phones to transmit electrocardiograms (ECGs) from the field

16 Oct 2005

Researchers find gene that is important for the control of fundamental rhythms in nematode worms

University of Utah biologists found a gene that controls rhythmic events in a worm's life: swallowing food, laying eggs and pooping.

9 Oct 2005

Researchers identify gene defect in mice that causes cyclical hair loss and skin cancer

Researchers at Jefferson Medical College and at the Wadsworth Center in New York have identified a gene defect in mice resulting in a range of abnormalities, from cyclical hair loss and skin cancer to severe problems in normal skin development.

4 Oct 2005

People use discretion in deciding when show up in the emergency department

When is a medical emergency really an emergency? Not during key Boston Red Sox games, report investigators from Children's Hospital Boston in a letter published in the October issue of Annals of Emergency Medicine.

26 Sep 2005

John Hopkins scientists uncover "tags" that force proteins to cell surface

Johns Hopkins scientists have discovered internal "shipping labels" that allow -- and perhaps force -- hundreds if not thousands of proteins to get to the surface of cells and stay there.

22 Sep 2005

Translation elongation factor eEF1A2 is is a potential oncogene that is overexpressed in two-thirds of breast tumors

The tissue-specific elongation factor eEF1A2 might be an oncoprotein involved in breast cancer.

12 Sep 2005

GenoMed has announced that it successfully treated its thirteenth patient with presumed West Nile virus encephalitis

The patient is a previously healthy man from Aberdeen, South Dakota who developed fever and headache and was diagnosed by his physician as having West Nile virus on Monday of this week. South Dakota has about 50 times higher incidence of West Nile virus this summer than California.

1 Sep 2005

Unrecognized hypertension is common among emergency room patients, especially African Americans

Half of the study participants with high blood pressure reported that they were not under medical care for the condition. Further, the majority of this group stated that they had never been told that they had high blood pressure.