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Study uses brain organoids to reveal how autism-linked genetic mutation disrupts neural development

In a study published May 02, 2022 in Nature Communications, scientists at University of California San Diego School of Medicine used human brain organoids to reveal how a genetic mutation associated with a profound form of autism disrupts neural development.

2 May 2022

The generation of SARS-CoV-2 virus-like particles in insect cells

Researchers have reported the development of a promising COVID-19 vaccine candidate which is based on SARS-CoV-2 VLPs, derived from the co-expression of the spike, membrane, and envelope structural proteins in the baculovirus expression system.

2 May 2022

Antibody cocktail shows synergetic effects against SARS-CoV-2 Omicron in vitro and in vivo

A recent research paper posted to the bioRxiv* preprint server demonstrated that a cocktail of two synergetic antibodies extensively neutralized severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants, including Omicron BA.1 and BA.2.

1 May 2022

Chimeric Delta-Omicron RBD-dimer vaccine found to be effective against SARS-CoV-2 variants

In a new study, researchers described their self-designed chimeric receptor-binding domain-dimer vaccine approach to adapt SARS-CoV-2 variants of concern and variants of interest.

29 Apr 2022

New insights into how NANOG protein facilitates the activation of human cell pluripotency

There are cells in the body known as pluripotent stem cells that are yet to specialize in a particular biological function.

28 Apr 2022

Evaluating nano alum as a substitute for conventional alum-based vaccine adjuvant

Researchers evaluated the performance and safety of nano alum adjuvant as next-generation coronavirus disease 2019 (COVID-19) vaccine antigens.

28 Apr 2022

Identification of a SARS-CoV-2 neutralizing human monoclonal antibody with a remarkable broad-spectrum neutralization and protection efficacy

Researchers identified a human monoclonal antibody (mAb), 87G7, with in vitro neutralizing activity against several SARS-CoV-2 VOCs, including Alpha, Beta, Gamma, Delta, and Omicron.

28 Apr 2022

Green tea catechin as pan-coronavirus attachment inhibitor

In a recent study posted to the Research Square* preprint server, researchers assessed the impact of green tea catechin epigallocatechin gallate (EGCG) on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

27 Apr 2022

Novel plug-and-play multi-organ chip can be customized to the patient

Engineered tissues have become a critical component for modeling diseases and testing the efficacy and safety of drugs in a human context.

27 Apr 2022

Combination therapy shows promise for treating triple-negative breast cancer

Researchers at Baylor College of Medicine and collaborating institutions have identified a combination therapy for treating triple-negative breast cancer (TNBC) that results in durable tumor regression in an animal model of the condition.

27 Apr 2022

The preclinical potential of a herb used in traditional Chinese medicine for the treatment of COVID-19

In a study published in Cells, researchers have been investigating the effects of this extract for use against COVID-19.

27 Apr 2022

Researchers reveal how not-yet-malignant cells “turn on” and become metastatic breast cancer

Mount Sinai researchers have discovered a previously unknown mechanism in which not-yet-malignant cells from early breast cancer tumors travel to other organs and, eventually, "turn on" and become metastatic breast cancer.

26 Apr 2022

New discovery about nature’s ‘high-end machinery’ could have big implications for biology

Working with tiny bacteria, Michigan State University researchers led by Lee Kroos have made a discovery that could have big implications for biology.

26 Apr 2022

Free fatty acid-binding pocket found to be preserved across spike proteins of beta coronaviruses

Researchers assessed the binding pocket of linoleic acid, an essential free-fatty acid in the receptor-binding domains of the spike protein of beta-coronaviruses.

26 Apr 2022

The response of four SARS-CoV-2 spike variants to linoleic acid removal

A recent paper depicted the differential allosteric response of the SARS-CoV-2 spike variants to linoleic acid.

26 Apr 2022

Quantum dot biomimetic for SARS-CoV-2 examines neurovascular dysregulation related to brain inflammation

Researchers developed SARS-CoV-2 virus-like nanoparticles with a quantum dots core.

26 Apr 2022

Dotphoton and Hamamatsu Photonics are partnering to provide the ultimate raw image compression and address the ever-growing biomedical image data volume

Dotphoton, an industry-leading raw image compression company and Hamamatsu Photonics, a world leader in optical systems and photonics manufacturing, are pleased to announce their new partnership.

From Hamamatsu Photonics Europe 26 Apr 2022

Exploring Populations of B and T Cells in Lymph Nodes of Patients Diagnosed with COVID-19 via Microscopy and Image Analysis

My work is focused on looking at the dynamics of B/T cell populations within lymph nodes from patients that had recovered from COVID-19. My role in this research was developing and implementing microscopy image analysis techniques using methods and instrumentation in part supplied by TissueGnostics.

From TissueGnostics 26 Apr 2022

ST6Gal-I–mediated sialylation of the EGFR modulates cell mechanics and enhances cancer invasion

For more than two decades, University of Alabama at Birmingham researcher Susan Bellis, Ph.D., has studied how the addition of sialic acid to various proteins increases cancer resistance and oncogenicity.

22 Apr 2022

The diversity of transcriptional targets between four different coronavirus nsp1 proteins

Researchers investigated variations in the host immune response-elicited by non-structural protein 1 of coronaviruses.

22 Apr 2022

Microscopy News and Research

Study uses brain organoids to reveal how autism-linked genetic mutation disrupts neural development

The generation of SARS-CoV-2 virus-like particles in insect cells

Antibody cocktail shows synergetic effects against SARS-CoV-2 Omicron in vitro and in vivo

Chimeric Delta-Omicron RBD-dimer vaccine found to be effective against SARS-CoV-2 variants

New insights into how NANOG protein facilitates the activation of human cell pluripotency

Evaluating nano alum as a substitute for conventional alum-based vaccine adjuvant

Identification of a SARS-CoV-2 neutralizing human monoclonal antibody with a remarkable broad-spectrum neutralization and protection efficacy

Green tea catechin as pan-coronavirus attachment inhibitor

Novel plug-and-play multi-organ chip can be customized to the patient

Combination therapy shows promise for treating triple-negative breast cancer

The preclinical potential of a herb used in traditional Chinese medicine for the treatment of COVID-19

Researchers reveal how not-yet-malignant cells “turn on” and become metastatic breast cancer

New discovery about nature’s ‘high-end machinery’ could have big implications for biology

Free fatty acid-binding pocket found to be preserved across spike proteins of beta coronaviruses

The response of four SARS-CoV-2 spike variants to linoleic acid removal

Quantum dot biomimetic for SARS-CoV-2 examines neurovascular dysregulation related to brain inflammation

Dotphoton and Hamamatsu Photonics are partnering to provide the ultimate raw image compression and address the ever-growing biomedical image data volume

Exploring Populations of B and T Cells in Lymph Nodes of Patients Diagnosed with COVID-19 via Microscopy and Image Analysis

ST6Gal-I–mediated sialylation of the EGFR modulates cell mechanics and enhances cancer invasion

The diversity of transcriptional targets between four different coronavirus nsp1 proteins

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