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A single base-resolution sequencing methodology that sequences the two most common cytosine modifications in a single workflow

Researchers developed a WGS method that read four canonical DNA bases, viz., adenine (A), cytosine (C), guanine (G), and thymine (T) plus 5mC and 5hmC, epigenetic variants of unmodified C to yield an accurate six-letter digital readout in a single workflow.

9 Feb 2023

Researchers discover small molecules that can lock SARS-CoV-2 spike proteins

The infamous spike proteins on the surface of SARS-CoV-2 help it bind to and enter human cells. Because of their important role in spreading infection, these spike proteins are one of the main targets for COVID-19 vaccines and treatments.

9 Feb 2023

Researchers identify new mechanism that causes hereditary diseases

Researchers from Charité – Universitätsmedizin Berlin, the Max Planck Institute for Molecular Genetics (MPIMG), and the University Hospital Schleswig-Holstein (UKSH) have investigated in detail how BPTA syndrome, an extremely rare hereditary condition, arises.

9 Feb 2023

Study reveals some of the fundamental biology of p97 protein in neurodegenerative disease

The p97 protein is one of your body's best garbage disposers. It floats around in your cells looking for signals that a protein is past its shelf life and needs to be trashed.

7 Feb 2023

UC researcher aims to develop better treatments for KRAS-mutated pancreatic cancer

Pancreatic cancer diagnoses are increasing more rapidly than any other cancer type while remaining one of the most deadly cancers.

7 Feb 2023

Bivalent boosters provide additional protection from BA.5, XBB, and XBB.1.5

In a recent Morbidity and Mortality Weekly Report (MMWR) published on the United States Center for Disease Control and Prevention (US-CDC) website, researchers analyzed data from the Increasing Community Access to Testing (ICATT), a nationwide pharmacy program run in the US for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) testing.

7 Feb 2023

Study characterizes mutations in neuraminidase of human-like H5N1 influenza viruses

A study published in PLOS PATHOGENS describes the prevalence and functions of mutations in neuraminidase enzyme of avian H5N1 influenza viruses that are preferentially selected in human H5N1 influenza viruses.

7 Feb 2023

Deletion of a tumor suppressor gene promotes luminal breast cancer development and resistance to endocrine therapy

A research team from LKS Faculty of Medicine, the University of Hong Kong (HKUMed) discovered that somatic deletion of a tumor suppressor gene AKTIP promotes luminal breast cancer development and resistance to endocrine therapy.

3 Feb 2023

SARS-CoV-2 infections on French mink farms after one year of COVID-19

A new paper, which appears on the bioRxiv* preprint server, describes the investigation of all French mink farms towards the end of 2020. This was to maximize the chances of identifying SARS-CoV-2 infection in these animals at any time over the past year.

3 Feb 2023

Pulmonary surfactant-mediated inflammatory response against SARS-CoV-2

Researchers discuss the role of a surfactant-mediated inflammatory response employed by human lungs against SARS-CoV-2.

3 Feb 2023

Molnupiravir-related mutational signatures among COVID-19 patients

Researchers explore a mutational signature related to molnupiravir in SARS-CoV-2 sequencing datasets.

3 Feb 2023

Understanding the mechanism of bedaquiline resistance in Mycobacterium marinum

Announcing a new article publication for Zoonoses journal. As infections caused by nontuberculous mycobacteria (NTM) are rapidly increasing globally, a need exists for developing novel antibiotics and discovering the mechanism of resistance

2 Feb 2023

Novel tool uses AI to predict the efficacy of genome-editing repair options

Researchers at the University of Zurich have developed a new tool that uses artificial intelligence to predict the efficacy of various genome-editing repair options.

2 Feb 2023

Microscopic technique enables real-time study of RNA G-quadruplexes in living cells

A new microscopic technique allows for the real-time study of RNA G-quadruplexes in living cells, with implications for the fight against amyotrophic lateral sclerosis.

2 Feb 2023

Characterization of Ikaros zinc finger protein 1 mutations in acute myeloid leukemia

Researchers evaluated the clinical and genetic characteristics of acute myeloid leukemia (AML) patients with a mutant Ikaros zinc finger protein 1 (IKZF1).

2 Feb 2023

Neutralizing antibodies to Toscana and Sandfly Fever Sicilian virus found in quails

The quail could be the unknown reservoir of the Toscana virus (TOSV) and the Sandfly Fever Sicilian virus (SFSV), mosquito-borne pathogens that can infect domestic animals and also cause disease in humans.

1 Feb 2023

Could novel lineages eventually dominate the viral population?

A new study puts forward a bottom-up approach to quickly predict whether a lineage will dominate the viral population, at a particular geographical location.

1 Feb 2023

Adding veliparib to chemotherapy can extend progression-free survival in patients with “BRCA-like” breast cancer

Results from the SWOG S1416 clinical trial show that adding veliparib to chemotherapy can significantly extend progression-free survival (PFS) times in patients with triple-negative breast cancer (TNBC) that has a "BRCA-like" phenotype.

31 Jan 2023

Study demonstrates intrahost MPXV variation within a single lesion

Researchers reported on the clinical and molecular characteristics of MPXV infections in Finland.

31 Jan 2023

Rapid engineering of novel SARS-CoV-2 therapeutic antibodies

Researchers assessed the influence of rapid engineering of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) therapeutic antibodies to expand the neutralization spectrum.

31 Jan 2023

Mutation News and Research

A single base-resolution sequencing methodology that sequences the two most common cytosine modifications in a single workflow

Researchers discover small molecules that can lock SARS-CoV-2 spike proteins

Researchers identify new mechanism that causes hereditary diseases

Study reveals some of the fundamental biology of p97 protein in neurodegenerative disease

UC researcher aims to develop better treatments for KRAS-mutated pancreatic cancer

Bivalent boosters provide additional protection from BA.5, XBB, and XBB.1.5

Study characterizes mutations in neuraminidase of human-like H5N1 influenza viruses

Deletion of a tumor suppressor gene promotes luminal breast cancer development and resistance to endocrine therapy

SARS-CoV-2 infections on French mink farms after one year of COVID-19

Pulmonary surfactant-mediated inflammatory response against SARS-CoV-2

Molnupiravir-related mutational signatures among COVID-19 patients

Understanding the mechanism of bedaquiline resistance in Mycobacterium marinum

Novel tool uses AI to predict the efficacy of genome-editing repair options

Microscopic technique enables real-time study of RNA G-quadruplexes in living cells

Characterization of Ikaros zinc finger protein 1 mutations in acute myeloid leukemia

Neutralizing antibodies to Toscana and Sandfly Fever Sicilian virus found in quails

Could novel lineages eventually dominate the viral population?

Adding veliparib to chemotherapy can extend progression-free survival in patients with “BRCA-like” breast cancer

Study demonstrates intrahost MPXV variation within a single lesion

Rapid engineering of novel SARS-CoV-2 therapeutic antibodies

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

Bringing real-time analytics to downstream bioprocess monitoring

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