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Unveiling leptin signaling in the DMH for metabolic effects

Scientists at Pennington Biomedical Research Center have gained greater clarity in the brain regions and neurons that control metabolism, body temperature and energy use.

27 Mar 2025

Study identifies PDGFRA as a potential target for pediatric high-grade gliomas

Pediatric high-grade gliomas, particularly H3K27M diffuse midline gliomas (DMG), are aggressive malignant brain tumors with a poor prognosis.

26 Mar 2025

Cabozantinib gains FDA approval for treating advanced neuroendocrine tumors

Cabozantinib, an oral tyrosine kinase inhibitor, has been approved by the U.S. Food and Drug Administration (FDA) for the treatment of patients with previously treated advanced neuroendocrine tumors (NETs).

26 Mar 2025

Fusion proteins enable the creation of monoclonal antibodies

The Food and Drug Administration has approved more than 100 monoclonal antibodies to treat a range of diseases. Other antibodies are used by physicians to diagnose conditions or by scientists to advance research projects.

26 Mar 2025

Scientists uncover rare gene variants that help people live past 100

Researchers studying over 2,000 Ashkenazi Jewish centenarians uncovered two rare IGF-1 gene variants linked to exceptional longevity. These variants reduce IGF-1 receptor activity through either diminished receptor binding or lower circulating IGF-1 levels.

26 Mar 2025

Flavonoids help regulate gut hormones and show promise in managing type 2 diabetes

Flavonoids show promise in treating type 2 diabetes mellitus by targeting the enteroendocrine system and regulating key gut hormones. They enhance insulin sensitivity, reduce oxidative stress, and influence appetite, glucose uptake, and hormone secretion.

26 Mar 2025

Researchers identify key gene linked to heroin addiction

Opioid use disorder is associated with more than 350,000 deaths annually worldwide. Guided by the need for an increased understanding of critical neurobiological features of addiction, researchers have now found a unique molecular signature and genes in the orbitofrontal cortex associated with heroin-seeking behavior.

26 Mar 2025

Yale study unlocks potential of lupus-related antibody to target cold tumors

Yale scientists have discovered a promising way to trigger immune responses against certain tumors, using a lupus-related antibody that can slip, undetected, into "cold" tumors and flip on an immune response that has been turned off by cancer.

25 Mar 2025

Postpartum females show shift in temperature preferences due to brain changes

Mothers experience major metabolic adaptations during pregnancy and lactation to support the development and growth of the new life.

25 Mar 2025

Anti-inflammatory drugs may reduce metabolic disease risk by inhibiting the sweet taste receptor

Past studies have shown that the human sweet taste receptor conveys sweet perception in the mouth and may help regulate glucose metabolism throughout the body.

25 Mar 2025

Blocking an inflammatory receptor in the retinas of aging mice improves retinal health

A new research paper was published in Aging (Aging-US) on January 31, 2025, in Volume 17, Issue 2, titled "Cysteinyl leukotriene receptor 1 modulates retinal immune cells, vascularity and proteolytic activity in aged mice."

25 Mar 2025

New brain metabolism model reveals key targets for reversing aging

The most comprehensive model of the brain’s metabolism, incorporating more than 16,800 biochemical interactions, has identified key targets to reverse the age-related decline in brain function.

25 Mar 2025

New insights into therapy resistance in breast cancer

A new review was published in Oncotarget, Volume 16, on March 13, 2025, titled "Signaling pathway dysregulation in breast cancer."

25 Mar 2025

Blocking Piezo2 may offer a new therapeutic approach for pulmonary fibrotic diseases

Researchers have found a potential new way to slow the progression of lung fibrosis and other fibrotic diseases by inhibiting the expression or function of Piezo2, a receptor that senses mechanical forces in tissues including stress, strain, and stiffness.

25 Mar 2025

Receptor News and Research

Unveiling leptin signaling in the DMH for metabolic effects

Study identifies PDGFRA as a potential target for pediatric high-grade gliomas

Cabozantinib gains FDA approval for treating advanced neuroendocrine tumors

Fusion proteins enable the creation of monoclonal antibodies

Scientists uncover rare gene variants that help people live past 100

Flavonoids help regulate gut hormones and show promise in managing type 2 diabetes

Researchers identify key gene linked to heroin addiction

Yale study unlocks potential of lupus-related antibody to target cold tumors

Postpartum females show shift in temperature preferences due to brain changes

Anti-inflammatory drugs may reduce metabolic disease risk by inhibiting the sweet taste receptor

Blocking an inflammatory receptor in the retinas of aging mice improves retinal health

New brain metabolism model reveals key targets for reversing aging

New insights into therapy resistance in breast cancer

Blocking Piezo2 may offer a new therapeutic approach for pulmonary fibrotic diseases

Scientists develop universal vaccine targeting multiple coronaviruses

Researchers develop TIM-3 decoy to enhance CAR-T therapy effectiveness for B-ALL tumors

Mount Sinai-led research uncovers mechanisms behind Crohn's disease inflammation

Eye drops show potential to slow progression of human degenerative retinal diseases

Natural compounds identified as potential inhibitors of SARS-CoV-2 spike protein

Exploring the therapeutic potential of flavonoids in type 2 diabetes

Industry Focus eBook - Life Science Microscopy (3rd Edition) eBook

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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